DegronMD - P42331(ARHGAP25)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L579I	TCGA-49-6744	LUAD	TCGA	EKENY	DEG_APCC_KENBOX_2	579:583	Mutation altering degron motif	0.7174
p.G514E	TCGA-55-8616	LUAD	TCGA	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation rewiring degron network	0.1667
p.P507S	TCGA-D3-A8GI	SKCM	TCGA	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation altering degron motif	0.6752
p.P507S	TCGA-YD-A9TA	SKCM	TCGA	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation altering degron motif	0.6752
p.Q570K	TCGA-DD-AADF	LIHC	TCGA	EKENY	DEG_APCC_KENBOX_2	579:583	Mutation rewiring degron network	0.0833
p.E515K	TCGA-FS-A1ZC	SKCM	TCGA	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation rewiring degron network	0.1389
p.E582K	TCGA-GF-A6C9	SKCM	TCGA	EKENY	DEG_APCC_KENBOX_2	579:583	Mutation altering degron motif	0.7022
p.E582K	TCGA-LH-A9QB	SKCM	TCGA	EKENY	DEG_APCC_KENBOX_2	579:583	Mutation altering degron motif	0.7022
p.R498W	DO8858	COAD	ICGC	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation rewiring degron network	0.3056
p.R498W	DO233151	GACA	ICGC	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation rewiring degron network	0.3056
p.N582K	DO8264	COAD	ICGC	EKENY	DEG_APCC_KENBOX_2	579:583	Mutation altering degron motif	0.6918
p.S517N	DO233882	GACA	ICGC	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation blocking phosphorylation signal	0.5278
p.R491L	DO50889	LICA	ICGC	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation rewiring degron network	0.1111
p.Q569K	DO52232	LIHC	ICGC	EKENY	DEG_APCC_KENBOX_2	579:583	Mutation rewiring degron network	0.0556
p.L578I	DO24160	LUAD	ICGC	EKENY	DEG_APCC_KENBOX_2	579:583	Mutation rewiring degron network	0.3056
p.G513E	DO23566	LUAD	ICGC	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation rewiring degron network	0.1944
p.E579Q	DO231040	LUSC	ICGC	EKENY	DEG_APCC_KENBOX_2	579:583	Mutation altering degron motif	0.5633
p.E581K	DO220882	MELA	ICGC	EKENY	DEG_APCC_KENBOX_2	579:583	Mutation altering degron motif	0.7022
p.E581K	DO51266	SKCM	ICGC	EKENY	DEG_APCC_KENBOX_2	579:583	Mutation altering degron motif	0.7022
p.E581K	DO51254	SKCM	ICGC	EKENY	DEG_APCC_KENBOX_2	579:583	Mutation altering degron motif	0.7022
p.D584N	DO222837	MELA	ICGC	EKENY	DEG_APCC_KENBOX_2	579:583	Mutation rewiring degron network	0.3056
p.S496F	DO222843	MELA	ICGC	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation rewiring degron network	0.25
p.R491H	DO227824	PBCA	ICGC	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation rewiring degron network	0.1111
p.R498Q	DO219877	SKCA	ICGC	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation rewiring degron network	0.3056
p.R498Q	DO218861	SKCA	ICGC	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation rewiring degron network	0.3056
p.E514K	DO37487	SKCM	ICGC	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation rewiring degron network	0.1667
p.P506S	DO50284	SKCM	ICGC	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation altering degron motif	0.6752
p.P506S	DO219503	SKCM	ICGC	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation altering degron motif	0.6752
p.S508Y	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation altering degron motif	0.712
p.S508Y	SU-DHL-4	haematopoietic and lymphoid tissue	COSMIC	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation altering degron motif	0.712
p.P513S	SIDM01109	Other Sarcomas	GDSC	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation rewiring degron network	0.1944
p.P513S	SIDM00027	Kidney Carcinoma	GDSC	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation rewiring degron network	0.1944
p.P513S	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation rewiring degron network	0.1944
p.V506I	SIDM01263	T-Lymphoblastic Leukemia	GDSC	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation altering degron motif	0.7076
p.G511A	SIDM00793	Burkitt's Lymphoma	GDSC	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation blocking phosphorylation signal	0.6944
p.G511A	SIDM00628	Breast Carcinoma	GDSC	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation blocking phosphorylation signal	0.6944
p.G511A	SIDM01318	Hepatocellular Carcinoma	GDSC	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation blocking phosphorylation signal	0.6944
p.S494I	ACH-000009	Colon/Colorectal Cancer	CCLE	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation blocking phosphorylation signal	0.6389
p.S494I	C2BBe1	large intestine	COSMIC	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation blocking phosphorylation signal	0.6389
p.K586R	ACH-000633	Gastric Cancer	CCLE	EKENY	DEG_APCC_KENBOX_2	579:583	Mutation rewiring degron network	0.25
p.K586R	FU97	stomach	COSMIC	EKENY	DEG_APCC_KENBOX_2	579:583	Mutation rewiring degron network	0.25
p.R572C	ACH-000897	Thyroid Cancer	CCLE	EKENY	DEG_APCC_KENBOX_2	579:583	Mutation rewiring degron network	0.1389
p.G500V	ACH-000955	Colon/Colorectal Cancer	CCLE	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation altering degron motif	0.7532
p.G500V	SNU-407	large intestine	COSMIC	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation altering degron motif	0.7532
p.R578W	ACH-000966	Ovarian Cancer	CCLE	EKENY	DEG_APCC_KENBOX_2	579:583	Mutation rewiring degron network	0.3056
p.R578W	IGROV-1	ovary	COSMIC	EKENY	DEG_APCC_KENBOX_2	579:583	Mutation rewiring degron network	0.3056
p.S513Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation rewiring degron network	0.1944
p.E589K	ACH-001127	Leukemia	CCLE	EKENY	DEG_APCC_KENBOX_2	579:583	Mutation rewiring degron network	0.1667
p.E589K	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	EKENY	DEG_APCC_KENBOX_2	579:583	Mutation rewiring degron network	0.1667
p.E590G	ACH-001688	Kidney Cancer	CCLE	EKENY	DEG_APCC_KENBOX_2	579:583	Mutation rewiring degron network	0.1389
p.E590G	FU-OV-1	ovary	COSMIC	EKENY	DEG_APCC_KENBOX_2	579:583	Mutation rewiring degron network	0.1389
p.Q515H	ACH-001853	Bile Duct Cancer	CCLE	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation rewiring degron network	0.1389
p.D580N	ACH-002388	Skin Cancer	CCLE	EKENY	DEG_APCC_KENBOX_2	579:583	Mutation altering degron motif	0.6932
p.E591G	FU-OV-1	ovary	COSMIC	EKENY	DEG_APCC_KENBOX_2	579:583	Mutation rewiring degron network	0.1111
p.S500Y	SU-DHL-4	haematopoietic and lymphoid tissue	COSMIC	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation altering degron motif	0.6009
p.E593K	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	EKENY	DEG_APCC_KENBOX_2	579:583	Mutation rewiring degron network	0.0556
p.E592K	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	EKENY	DEG_APCC_KENBOX_2	579:583	Mutation rewiring degron network	0.0833
p.S501Y	SU-DHL-4	haematopoietic and lymphoid tissue	COSMIC	TSTYDNVPSL	DEG_COP1_1	499:508	Mutation altering degron motif	0.712

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGAP25

UniProt ID: P42331

Entrez ID: 9938

Protein name: Rho GTPase-activating protein 25 (Rho-type GTPase-activating protein 25)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGAP25 in