DegronMD

Uniprot ID: P42331

Source protein: Rho GTPase-activating protein 25

Source gene: ARHGAP25

Class: DEG_COP1_1

Location: 499:508

E3 ligase: COP1

DEGRON score: 0.9968

ASA_SCORE: 85.34

COIL: 0.9477

CONS_SCORE: 0.4508

DSS_SCORE: 0.7199

HELIX: 0.0335

FCONS_SCORE: 1.1071

RIG_SCORE: 0.6428

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G514E	TCGA-55-8616	LUAD	TCGA	TSTYDNVPSL	DEG_COP1_1	0.1667
p.P507S	TCGA-D3-A8GI	SKCM	TCGA	TSTYDNVPSL	DEG_COP1_1	0.6752
p.P507S	TCGA-YD-A9TA	SKCM	TCGA	TSTYDNVPSL	DEG_COP1_1	0.6752
p.E515K	TCGA-FS-A1ZC	SKCM	TCGA	TSTYDNVPSL	DEG_COP1_1	0.1389
p.R498W	DO8858	COAD	ICGC	TSTYDNVPSL	DEG_COP1_1	0.3056
p.R498W	DO233151	GACA	ICGC	TSTYDNVPSL	DEG_COP1_1	0.3056
p.S517N	DO233882	GACA	ICGC	TSTYDNVPSL	DEG_COP1_1	0.5278
p.R491L	DO50889	LICA	ICGC	TSTYDNVPSL	DEG_COP1_1	0.1111
p.G513E	DO23566	LUAD	ICGC	TSTYDNVPSL	DEG_COP1_1	0.1944
p.S496F	DO222843	MELA	ICGC	TSTYDNVPSL	DEG_COP1_1	0.25
p.R491H	DO227824	PBCA	ICGC	TSTYDNVPSL	DEG_COP1_1	0.1111
p.R498Q	DO219877	SKCA	ICGC	TSTYDNVPSL	DEG_COP1_1	0.3056
p.R498Q	DO218861	SKCA	ICGC	TSTYDNVPSL	DEG_COP1_1	0.3056
p.E514K	DO37487	SKCM	ICGC	TSTYDNVPSL	DEG_COP1_1	0.1667
p.P506S	DO50284	SKCM	ICGC	TSTYDNVPSL	DEG_COP1_1	0.6752
p.P506S	DO219503	SKCM	ICGC	TSTYDNVPSL	DEG_COP1_1	0.6752
p.S508Y	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	TSTYDNVPSL	DEG_COP1_1	0.712
p.S508Y	SU-DHL-4	haematopoietic_and_lymphoid_tissue	COSMIC	TSTYDNVPSL	DEG_COP1_1	0.712
p.P513S	SIDM01109	Other Sarcomas	GDSC	TSTYDNVPSL	DEG_COP1_1	0.1944
p.P513S	SIDM00027	Kidney Carcinoma	GDSC	TSTYDNVPSL	DEG_COP1_1	0.1944
p.P513S	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	TSTYDNVPSL	DEG_COP1_1	0.1944
p.V506I	SIDM01263	T-Lymphoblastic Leukemia	GDSC	TSTYDNVPSL	DEG_COP1_1	0.7076
p.G511A	SIDM00793	Burkitt's Lymphoma	GDSC	TSTYDNVPSL	DEG_COP1_1	0.6944
p.G511A	SIDM00628	Breast Carcinoma	GDSC	TSTYDNVPSL	DEG_COP1_1	0.6944
p.G511A	SIDM01318	Hepatocellular Carcinoma	GDSC	TSTYDNVPSL	DEG_COP1_1	0.6944
p.S494I	ACH-000009	Colon/Colorectal Cancer	CCLE	TSTYDNVPSL	DEG_COP1_1	0.6389
p.S494I	C2BBe1	large_intestine	COSMIC	TSTYDNVPSL	DEG_COP1_1	0.6389
p.G500V	ACH-000955	Colon/Colorectal Cancer	CCLE	TSTYDNVPSL	DEG_COP1_1	0.7532
p.G500V	SNU-407	large_intestine	COSMIC	TSTYDNVPSL	DEG_COP1_1	0.7532
p.S513Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	TSTYDNVPSL	DEG_COP1_1	0.1944
p.Q515H	ACH-001853	Bile Duct Cancer	CCLE	TSTYDNVPSL	DEG_COP1_1	0.1389
p.S500Y	SU-DHL-4	haematopoietic_and_lymphoid_tissue	COSMIC	TSTYDNVPSL	DEG_COP1_1	0.6009
p.S501Y	SU-DHL-4	haematopoietic_and_lymphoid_tissue	COSMIC	TSTYDNVPSL	DEG_COP1_1	0.712

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TSTYDNVPSL

Degron related mutations and impact score

Drug responses associated with ARHGAP25 mutations

All proteins holding degron of TSTYDNVPSL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42331	Rho GTPase-activating protein 25	DEG_COP1_1	499:508	TSTYDNVPSL	COP1	0.9968	More...