DegronMD

Uniprot ID: P42331

Source protein: Rho GTPase-activating protein 25

Source gene: ARHGAP25

Class: DEG_APCC_KENBOX_2

Location: 579:583

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.988

ASA_SCORE: 122.78

COIL: 0.4188

CONS_SCORE: 0.5121

DSS_SCORE: 0.1722

HELIX: 0.5884

FCONS_SCORE: 1.2489

RIG_SCORE: 0.8089

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L579I	TCGA-49-6744	LUAD	TCGA	EKENY	DEG_APCC_KENBOX_2	0.7174
p.Q570K	TCGA-DD-AADF	LIHC	TCGA	EKENY	DEG_APCC_KENBOX_2	0.0833
p.E582K	TCGA-GF-A6C9	SKCM	TCGA	EKENY	DEG_APCC_KENBOX_2	0.7022
p.E582K	TCGA-LH-A9QB	SKCM	TCGA	EKENY	DEG_APCC_KENBOX_2	0.7022
p.N582K	DO8264	COAD	ICGC	EKENY	DEG_APCC_KENBOX_2	0.6918
p.Q569K	DO52232	LIHC	ICGC	EKENY	DEG_APCC_KENBOX_2	0.0556
p.L578I	DO24160	LUAD	ICGC	EKENY	DEG_APCC_KENBOX_2	0.3056
p.E579Q	DO231040	LUSC	ICGC	EKENY	DEG_APCC_KENBOX_2	0.5633
p.E581K	DO220882	MELA	ICGC	EKENY	DEG_APCC_KENBOX_2	0.7022
p.E581K	DO51266	SKCM	ICGC	EKENY	DEG_APCC_KENBOX_2	0.7022
p.E581K	DO51254	SKCM	ICGC	EKENY	DEG_APCC_KENBOX_2	0.7022
p.D584N	DO222837	MELA	ICGC	EKENY	DEG_APCC_KENBOX_2	0.3056
p.K586R	ACH-000633	Gastric Cancer	CCLE	EKENY	DEG_APCC_KENBOX_2	0.25
p.K586R	FU97	stomach	COSMIC	EKENY	DEG_APCC_KENBOX_2	0.25
p.R572C	ACH-000897	Thyroid Cancer	CCLE	EKENY	DEG_APCC_KENBOX_2	0.1389
p.R578W	ACH-000966	Ovarian Cancer	CCLE	EKENY	DEG_APCC_KENBOX_2	0.3056
p.R578W	IGROV-1	ovary	COSMIC	EKENY	DEG_APCC_KENBOX_2	0.3056
p.E589K	ACH-001127	Leukemia	CCLE	EKENY	DEG_APCC_KENBOX_2	0.1667
p.E589K	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	EKENY	DEG_APCC_KENBOX_2	0.1667
p.E590G	ACH-001688	Kidney Cancer	CCLE	EKENY	DEG_APCC_KENBOX_2	0.1389
p.E590G	FU-OV-1	ovary	COSMIC	EKENY	DEG_APCC_KENBOX_2	0.1389
p.D580N	ACH-002388	Skin Cancer	CCLE	EKENY	DEG_APCC_KENBOX_2	0.6932
p.E591G	FU-OV-1	ovary	COSMIC	EKENY	DEG_APCC_KENBOX_2	0.1111
p.E593K	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	EKENY	DEG_APCC_KENBOX_2	0.0556
p.E592K	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	EKENY	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42331	Rho GTPase-activating protein 25	DEG_APCC_KENBOX_2	579:583	EKENY	APC,CDC20,FZR1	0.988	More...
Q99959	Plakophilin-2	DEG_APCC_KENBOX_2	257:261	EKENY	APC,CDC20,FZR1	0.9626	More...
Q9NV35	Nucleotide triphosphate diphosphatase NUDT15	DEG_APCC_KENBOX_2	86:90	EKENY	APC,CDC20,FZR1	0.6218	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EKENY

Degron related mutations and impact score

Drug responses associated with ARHGAP25 mutations

All proteins holding degron of EKENY