DegronMD

Uniprot ID: Q9NV35

Source protein: Nucleotide triphosphate diphosphatase NUDT15

Source gene: NUDT15

Class: DEG_APCC_KENBOX_2

Location: 86:90

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6218

ASA_SCORE: 104.6

COIL: 0.6546

CONS_SCORE: 0.5774

DSS_SCORE: 0.0922

HELIX: 0.0644

FCONS_SCORE: 0.8816

RIG_SCORE: 0.8323

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S83Y	TCGA-AA-3984	COAD	TCGA	EKENY	DEG_APCC_KENBOX_2	0.25
p.S83Y	TCGA-AG-A002	READ	TCGA	EKENY	DEG_APCC_KENBOX_2	0.25
p.S83Y	TCGA-AP-A056	UCEC	TCGA	EKENY	DEG_APCC_KENBOX_2	0.25
p.S83Y	TCGA-EI-6917	READ	TCGA	EKENY	DEG_APCC_KENBOX_2	0.25
p.S83Y	TCGA-EY-A1G8	UCEC	TCGA	EKENY	DEG_APCC_KENBOX_2	0.25
p.S83Y	DO9002	COAD	ICGC	EKENY	DEG_APCC_KENBOX_2	0.25
p.S83Y	DO36881	READ	ICGC	EKENY	DEG_APCC_KENBOX_2	0.25
p.S83Y	DO43578	UCEC	ICGC	EKENY	DEG_APCC_KENBOX_2	0.25
p.S83Y	DO43971	UCEC	ICGC	EKENY	DEG_APCC_KENBOX_2	0.25
p.Y92D	TCGA-CA-6718	COAD	TCGA	EKENY	DEG_APCC_KENBOX_2	0.2778
p.Y92D	DO7801	COAD	ICGC	EKENY	DEG_APCC_KENBOX_2	0.2778
p.M97I	TCGA-FI-A2EW	UCEC	TCGA	EKENY	DEG_APCC_KENBOX_2	0.1389
p.M97I	DO41500	UCEC	ICGC	EKENY	DEG_APCC_KENBOX_2	0.1389
p.E86K	DO48396	BLCA	ICGC	EKENY	DEG_APCC_KENBOX_2	0.591
p.V81L	DO229026	LICA	ICGC	EKENY	DEG_APCC_KENBOX_2	0.1944
p.A78S	DO229031	LICA	ICGC	EKENY	DEG_APCC_KENBOX_2	0.1111
p.T94I	DO230453	UTCA	ICGC	EKENY	DEG_APCC_KENBOX_2	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42331	Rho GTPase-activating protein 25	DEG_APCC_KENBOX_2	579:583	EKENY	APC,CDC20,FZR1	0.988	More...
Q99959	Plakophilin-2	DEG_APCC_KENBOX_2	257:261	EKENY	APC,CDC20,FZR1	0.9626	More...
Q9NV35	Nucleotide triphosphate diphosphatase NUDT15	DEG_APCC_KENBOX_2	86:90	EKENY	APC,CDC20,FZR1	0.6218	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons