DegronMD

Uniprot ID: Q99959

Source protein: Plakophilin-2

Source gene: PKP2

Class: DEG_APCC_DBOX_1

Location: 394:402

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7102

ASA_SCORE: 53.4333

COIL: 0.4256

CONS_SCORE: 0.6622

DSS_SCORE: 0.0504

HELIX: 0.5288

FCONS_SCORE: 1.2041

RIG_SCORE: 0.9083

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R388W	TCGA-D3-A8GI	SKCM	TCGA	LRGILKLLQ	DEG_APCC_DBOX_1	0.1667
p.R388W	DO229456	SKCA	ICGC	LRGILKLLQ	DEG_APCC_DBOX_1	0.1667
p.R388W	DO50284	SKCM	ICGC	LRGILKLLQ	DEG_APCC_DBOX_1	0.1667
p.R390K	TCGA-D3-A8GL	SKCM	TCGA	LRGILKLLQ	DEG_APCC_DBOX_1	0.2222
p.R390K	DO50287	SKCM	ICGC	LRGILKLLQ	DEG_APCC_DBOX_1	0.2222
p.R390K	Sarc9371	bone	COSMIC	LRGILKLLQ	DEG_APCC_DBOX_1	0.2222
p.R395C	TCGA-EE-A2MR	SKCM	TCGA	LRGILKLLQ	DEG_APCC_DBOX_1	0.8301
p.R395C	TCGA-ER-A199	SKCM	TCGA	LRGILKLLQ	DEG_APCC_DBOX_1	0.8301
p.R395C	TCGA-YG-AA3N	SKCM	TCGA	LRGILKLLQ	DEG_APCC_DBOX_1	0.8301
p.R395C	DO222702	MELA	ICGC	LRGILKLLQ	DEG_APCC_DBOX_1	0.8301
p.R395C	DO37819	SKCM	ICGC	LRGILKLLQ	DEG_APCC_DBOX_1	0.8301
p.R395C	DO47395	SKCM	ICGC	LRGILKLLQ	DEG_APCC_DBOX_1	0.8301
p.R395C	DO51298	SKCM	ICGC	LRGILKLLQ	DEG_APCC_DBOX_1	0.8301
p.L394F	TCGA-FW-A3R5	SKCM	TCGA	LRGILKLLQ	DEG_APCC_DBOX_1	0.587
p.L394F	DO37406	SKCM	ICGC	LRGILKLLQ	DEG_APCC_DBOX_1	0.587
p.G396D	DO228957	LICA	ICGC	LRGILKLLQ	DEG_APCC_DBOX_1	0.6087
p.Q407K	DO229038	LICA	ICGC	LRGILKLLQ	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99959	Plakophilin-2	DEG_APCC_DBOX_1	394:402	LRGILKLLQ	APC,CDC20,FZR1	0.7102	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons