DegronMD - Q6VAB6(KSR2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P273L	TCGA-12-5299	GBM	TCGA	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation altering degron motif	0.7582
p.P273L	ACH-001610	Brain Cancer	CCLE	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation altering degron motif	0.7582
p.P273Q	TCGA-43-3920	LUSC	TCGA	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation altering degron motif	0.7035
p.P273Q	DO26445	LUSC	ICGC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation altering degron motif	0.7035
p.Q496E	TCGA-74-6575	GBM	TCGA	PPRY	ITCH	486:489	Mutation rewiring degron network	0.1389
p.P476L	TCGA-A5-A0G2	UCEC	TCGA	PPRY	ITCH	486:489	Mutation rewiring degron network	0.0556
p.P476L	TCGA-D3-A2JP	SKCM	TCGA	PPRY	ITCH	486:489	Mutation rewiring degron network	0.0556
p.P476L	DO222662	MELA	ICGC	PPRY	ITCH	486:489	Mutation rewiring degron network	0.0556
p.P476L	DO47407	SKCM	ICGC	PPRY	ITCH	486:489	Mutation rewiring degron network	0.0556
p.P476L	DO41235	UCEC	ICGC	PPRY	ITCH	486:489	Mutation rewiring degron network	0.0556
p.T524M	TCGA-A6-2686	COAD	TCGA	PSSTT	DEG_SPOP_SBC_1	521:525	Mutation altering degron motif	0.7423
p.T524M	DO7828	COAD	ICGC	PSSTT	DEG_SPOP_SBC_1	521:525	Mutation altering degron motif	0.7423
p.R263H	TCGA-A6-4107	COAD	TCGA	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation altering degron motif	0.7133
p.R263H	TCGA-BR-4184	STAD	TCGA	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation altering degron motif	0.7133
p.R263H	TCGA-FI-A2D5	UCEC	TCGA	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation altering degron motif	0.7133
p.R263H	ACH-000990	Endometrial/Uterine Cancer	CCLE	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation altering degron motif	0.7133
p.R263C	TCGA-AA-A01R	COAD	TCGA	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation altering degron motif	0.719
p.R263C	TCGA-B5-A5OC	UCEC	TCGA	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation altering degron motif	0.719
p.R263C	DO7934	COAD	ICGC	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation altering degron motif	0.719
p.R263C	DO52405	UCEC	ICGC	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation altering degron motif	0.719
p.R263C	ACH-000007	Colon/Colorectal Cancer	CCLE	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation altering degron motif	0.719
p.R263C	LS-513	large intestine	COSMIC	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation altering degron motif	0.719
p.R253Q	TCGA-AJ-A2QO	UCEC	TCGA	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation rewiring degron network	0.1944
p.R253Q	TCGA-HT-8563	LGG	TCGA	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation rewiring degron network	0.1944
p.R488H	TCGA-B5-A3FC	UCEC	TCGA	PPRY	ITCH	486:489	Mutation altering degron motif	0.7133
p.T270I	TCGA-BF-A1PX	SKCM	TCGA	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation blocking phosphorylation signal	0.6111
p.T270I	TCGA-BF-A1PX	SKCM	TCGA	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation blocking phosphorylation signal	0.75
p.T270I	DO51236	SKCM	ICGC	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation blocking phosphorylation signal	0.6111
p.T270I	DO51236	SKCM	ICGC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation blocking phosphorylation signal	0.75
p.A257V	TCGA-BR-7851	STAD	TCGA	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation rewiring degron network	0.3056
p.P482S	TCGA-CG-4437	STAD	TCGA	PPRY	ITCH	486:489	Mutation rewiring degron network	0.2222
p.P482S	TCGA-FW-A3R5	SKCM	TCGA	PPRY	ITCH	486:489	Mutation rewiring degron network	0.2222
p.S531L	TCGA-D3-A51T	SKCM	TCGA	PSSTT	DEG_SPOP_SBC_1	521:525	Mutation rewiring degron network	0.1667
p.S531L	TCGA-EE-A3JD	SKCM	TCGA	PSSTT	DEG_SPOP_SBC_1	521:525	Mutation rewiring degron network	0.1667
p.P273S	TCGA-D3-A5GR	SKCM	TCGA	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation altering degron motif	0.6752
p.S294F	TCGA-D3-A8GI	SKCM	TCGA	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation altering degron motif	0.9093
p.S294F	TCGA-GF-A3OT	SKCM	TCGA	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation altering degron motif	0.9093
p.S294F	DO47288	SKCM	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation altering degron motif	0.9093
p.S294F	DO50284	SKCM	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation altering degron motif	0.9093
p.P261L	TCGA-DU-5870	LGG	TCGA	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation altering degron motif	0.7582
p.R296Q	TCGA-EE-A29D	SKCM	TCGA	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation rewiring degron network	0.2778
p.R296Q	DO220902	MELA	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation rewiring degron network	0.2778
p.R296Q	DO38123	SKCM	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation rewiring degron network	0.2778
p.P261S	TCGA-EE-A29G	SKCM	TCGA	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation altering degron motif	0.6752
p.D478N	TCGA-EE-A2MF	SKCM	TCGA	PPRY	ITCH	486:489	Mutation rewiring degron network	0.1111
p.P274S	TCGA-EE-A3AB	SKCM	TCGA	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation altering degron motif	0.5641
p.P274S	DO222670	MELA	ICGC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation altering degron motif	0.5641
p.P274S	DO38057	SKCM	ICGC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation altering degron motif	0.5641
p.L301S	TCGA-F7-A624	HNSC	TCGA	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation rewiring degron network	0.1389
p.P499T	TCGA-FS-A1ZB	SKCM	TCGA	PPRY	ITCH	486:489	Mutation rewiring degron network	0.0556
p.G289E	TCGA-FS-A1ZW	SKCM	TCGA	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation altering degron motif	0.6087
p.R484Q	TCGA-FW-A3R5	SKCM	TCGA	PPRY	ITCH	486:489	Mutation rewiring degron network	0.2778
p.R484Q	DO222363	MELA	ICGC	PPRY	ITCH	486:489	Mutation rewiring degron network	0.2778
p.P512R	TCGA-J4-AATZ	PRAD	TCGA	PDSSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.25
p.P512R	TCGA-J4-AATZ	PRAD	TCGA	PSSTT	DEG_SPOP_SBC_1	521:525	Mutation rewiring degron network	0.0833
p.K485T	TCGA-L5-A4OT	ESCA	TCGA	PPRY	ITCH	486:489	Mutation rewiring degron network	0.3056
p.K485T	DO233165	GACA	ICGC	PPRY	ITCH	486:489	Mutation rewiring degron network	0.3056
p.H508D	TCGA-RR-A6KA	GBM	TCGA	PDSSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1389
p.H508D	DO51167	GBM	ICGC	PDSSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1389
p.S517F	TCGA-VQ-A8P2	STAD	TCGA	PDSSS	DEG_SPOP_SBC_1	515:519	Mutation altering degron motif	0.7982
p.S251L	TCGA-W3-A828	SKCM	TCGA	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation rewiring degron network	0.1389
p.G304E	TCGA-YG-AA3N	SKCM	TCGA	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation rewiring degron network	0.0556
p.P299H	DO7922	COAD	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation rewiring degron network	0.1944
p.P513L	DO9708	COAD	ICGC	PDSSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.2778
p.P513L	DO9708	COAD	ICGC	PSSTT	DEG_SPOP_SBC_1	521:525	Mutation rewiring degron network	0.1111
p.S284Y	DO222492	COCA	ICGC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation substituting flanking lysine	0.2222
p.S284Y	DO222492	COCA	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation substituting flanking lysine	0.3611
p.R484W	DO222769	COCA	ICGC	PPRY	ITCH	486:489	Mutation rewiring degron network	0.2778
p.T298M	DO50436	ESAD	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation rewiring degron network	0.2222
p.T298M	DO234389	ESAD	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation rewiring degron network	0.2222
p.T298M	DO49060	HNSC	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation rewiring degron network	0.2222
p.P274L	DO234230	ESAD	ICGC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation altering degron motif	0.6471
p.P258L	DO234269	ESAD	ICGC	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation altering degron motif	0.7582
p.T497M	DO234401	ESAD	ICGC	PPRY	ITCH	486:489	Mutation blocking phosphorylation signal	0.5556
p.P303L	DO233058	GACA	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation rewiring degron network	0.0833
p.I273M	DO233142	GACA	ICGC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation altering degron motif	0.7618
p.H280Y	DO233641	GACA	ICGC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation rewiring degron network	0.2222
p.H280Y	DO233641	GACA	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation rewiring degron network	0.1389
p.R259H	DO233864	GACA	ICGC	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation altering degron motif	0.7133
p.R259H	DO228142	PBCA	ICGC	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation altering degron motif	0.7133
p.L272S	DO44440	HNSC	ICGC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation altering degron motif	0.7667
p.F276L	DO229029	LICA	ICGC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation altering degron motif	0.6981
p.F276L	DO229026	LICA	ICGC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation altering degron motif	0.6981
p.H493Q	DO229031	LICA	ICGC	PPRY	ITCH	486:489	Mutation rewiring degron network	0.2222
p.P529T	DO229045	LICA	ICGC	PDSSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.0556
p.P529T	DO229045	LICA	ICGC	PSSTT	DEG_SPOP_SBC_1	521:525	Mutation rewiring degron network	0.2222
p.D294E	DO229009	LICA	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation altering degron motif	0.6758
p.D294E	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation altering degron motif	0.6758
p.D294E	SIDM00426	Rhabdomyosarcoma	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation altering degron motif	0.6758
p.D294E	SIDM00761	Small Cell Lung Carcinoma	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation altering degron motif	0.6758
p.D294E	SIDM00871	Non-Cancerous	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation altering degron motif	0.6758
p.D294E	SIDM00872	Breast Carcinoma	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation altering degron motif	0.6758
p.S282N	DO23633	LUAD	ICGC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation substituting flanking lysine	0.2778
p.S282N	DO23633	LUAD	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation substituting flanking lysine	0.3056
p.P265S	DO220907	MELA	ICGC	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation rewiring degron network	0.3056
p.P265S	DO220907	MELA	ICGC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation rewiring degron network	0.1667
p.R280K	DO51474	PACA	ICGC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation rewiring degron network	0.2222
p.R280K	DO51474	PACA	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation rewiring degron network	0.1389
p.K281T	DO230589	PRAD	ICGC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation substituting flanking lysine	0.3056
p.K281T	DO230589	PRAD	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation substituting flanking lysine	0.2778
p.P483R	DO219261	PRAD	ICGC	PPRY	ITCH	486:489	Mutation rewiring degron network	0.25
p.G260E	DO37519	SKCM	ICGC	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation altering degron motif	0.7199
p.P299S	DO48550	SKCM	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation rewiring degron network	0.1944
p.G275E	DO51298	SKCM	ICGC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation altering degron motif	0.6087
p.A278V	DO38475	STAD	ICGC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation rewiring degron network	0.2778
p.A278V	DO38475	STAD	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation rewiring degron network	0.0833
p.A278V	SIDM02051	Colorectal Carcinoma	GDSC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation rewiring degron network	0.2778
p.A278V	SIDM02051	Colorectal Carcinoma	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation rewiring degron network	0.0833
p.S488F	DO51761	STAD	ICGC	PPRY	ITCH	486:489	Mutation altering degron motif	0.7982
p.P263L	SIDM01943	Colorectal Carcinoma	GDSC	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation altering degron motif	0.7582
p.T496A	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PPRY	ITCH	486:489	Mutation rewiring degron network	0.1389
p.T496A	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PPRY	ITCH	486:489	Mutation rewiring degron network	0.1389
p.D487N	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPRY	ITCH	486:489	Mutation altering degron motif	0.6932
p.D487N	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PPRY	ITCH	486:489	Mutation altering degron motif	0.6932
p.R281W	SIDM00684	Glioblastoma	GDSC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation substituting flanking lysine	0.3056
p.R281W	SIDM00684	Glioblastoma	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation substituting flanking lysine	0.2778
p.R281W	LN-229	central nervous system	COSMIC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation substituting flanking lysine	0.3056
p.R281W	LN-229	central nervous system	COSMIC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation substituting flanking lysine	0.2778
p.P248S	SIDM00660	Colorectal Carcinoma	GDSC	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation rewiring degron network	0.0556
p.P248S	LS-411N	large intestine	COSMIC	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation rewiring degron network	0.0556
p.E295K	SIDM00337	Melanoma	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation rewiring degron network	0.3056
p.E295K	MEL-HO	skin	COSMIC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation rewiring degron network	0.3056
p.R292L	SIDM00719	Small Cell Lung Carcinoma	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation altering degron motif	0.8428
p.R292L	NCI-H345	lung	COSMIC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation altering degron motif	0.8428
p.R292H	SIDM00683	Prostate Carcinoma	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation altering degron motif	0.8244
p.R292H	LNCaP-Clone-FGC	prostate	COSMIC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation altering degron motif	0.8244
p.S284F	SIDM00251	Gastric Carcinoma	GDSC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation substituting flanking lysine	0.2222
p.S284F	SIDM00251	Gastric Carcinoma	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation substituting flanking lysine	0.3611
p.S284F	TGBC11TKB	stomach	COSMIC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation substituting flanking lysine	0.2222
p.S284F	TGBC11TKB	stomach	COSMIC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation substituting flanking lysine	0.3611
p.L507F	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1111
p.L507F	TE-5	oesophagus	COSMIC	PDSSS	DEG_SPOP_SBC_1	515:519	Mutation rewiring degron network	0.1111
p.P521R	SIDM00870	Breast Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	521:525	Mutation altering degron motif	0.7512
p.P521R	HCC202	breast	COSMIC	PSSTT	DEG_SPOP_SBC_1	521:525	Mutation altering degron motif	0.7512
p.P264L	SIDM00150	Colorectal Carcinoma	GDSC	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation altering degron motif	0.7582
p.P264L	KM12	large intestine	COSMIC	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation altering degron motif	0.7582
p.R525L	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	521:525	Mutation altering degron motif	0.8428
p.A278T	SIDM01612	Endometrial Carcinoma	GDSC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation rewiring degron network	0.2778
p.A278T	SIDM01612	Endometrial Carcinoma	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation rewiring degron network	0.0833
p.V268L	ACH-000250	Kidney Cancer	CCLE	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation rewiring degron network	0.2222
p.V268L	ACH-000250	Kidney Cancer	CCLE	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation rewiring degron network	0.25
p.V268L	KMRC-20	kidney	COSMIC	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation rewiring degron network	0.2222
p.V268L	KMRC-20	kidney	COSMIC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation rewiring degron network	0.25
p.R255W	ACH-000383	Esophageal Cancer	CCLE	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation rewiring degron network	0.25
p.R255W	ACH-000694	Esophageal Cancer	CCLE	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation rewiring degron network	0.25
p.R255W	OE33	oesophagus	COSMIC	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation rewiring degron network	0.25
p.P499L	ACH-000553	Lung Cancer	CCLE	PPRY	ITCH	486:489	Mutation rewiring degron network	0.0556
p.N480S	ACH-000768	Breast Cancer	CCLE	PPRY	ITCH	486:489	Mutation rewiring degron network	0.1667
p.N480S	MDA-MB-231	breast	COSMIC	PPRY	ITCH	486:489	Mutation rewiring degron network	0.1667
p.P262L	ACH-000915	Skin Cancer	CCLE	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation altering degron motif	0.6471
p.P262L	IPC-298	skin	COSMIC	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation altering degron motif	0.6471
p.P293L	ACH-000969	Colon/Colorectal Cancer	CCLE	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation altering degron motif	0.6471
p.P293L	KM12	large intestine	COSMIC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation altering degron motif	0.6471
p.T525A	ACH-000983	Leukemia	CCLE	PSSTT	DEG_SPOP_SBC_1	521:525	Mutation altering degron motif	0.7139
p.T525A	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PSSTT	DEG_SPOP_SBC_1	521:525	Mutation altering degron motif	0.7139
p.P277S	ACH-000985	Colon/Colorectal Cancer	CCLE	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation rewiring degron network	0.3056
p.P277S	ACH-000985	Colon/Colorectal Cancer	CCLE	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation rewiring degron network	0.0556
p.P277S	LS-411N	large intestine	COSMIC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation rewiring degron network	0.3056
p.P277S	LS-411N	large intestine	COSMIC	PPGTPPPS	DEG_SCF_FBW7_1	287:294	Mutation rewiring degron network	0.0556
p.I267L	ACH-000987	Skin Cancer	CCLE	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation rewiring degron network	0.25
p.I267L	ACH-000987	Skin Cancer	CCLE	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation rewiring degron network	0.2222
p.I267L	Mewo	skin	COSMIC	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation rewiring degron network	0.25
p.I267L	Mewo	skin	COSMIC	VTPPGT	DEG_SCF_FBW7_1	271:276	Mutation rewiring degron network	0.2222
p.D516N	ACH-000995	Leukemia	CCLE	PDSSS	DEG_SPOP_SBC_1	515:519	Mutation altering degron motif	0.5821
p.D516N	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PDSSS	DEG_SPOP_SBC_1	515:519	Mutation altering degron motif	0.5821
p.P250T	ACH-002272	Lymphoma	CCLE	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation rewiring degron network	0.1111
p.P250T	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	VRTPPRT	DEG_SCF_FBW7_1	258:264	Mutation rewiring degron network	0.1111
p.N481T	HCC1569	breast	COSMIC	PPRY	ITCH	486:489	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KSR2

UniProt ID: Q6VAB6

Entrez ID: 283455

Protein name: Kinase suppressor of Ras 2 (hKSR2) (EC 2.7.11.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KSR2 in