DegronMD

Uniprot ID: Q6VAB6

Source protein: Kinase suppressor of Ras 2

Source gene: KSR2

Class: DEG_SCF_FBW7_1

Location: 271:276

E3 ligase: FBXW7

DEGRON score: 0.9969

ASA_SCORE: 83.5667

COIL: 0.9822

CONS_SCORE: 0.3783

DSS_SCORE: 0.7884

HELIX: 0.0063

FCONS_SCORE: 1.0834

RIG_SCORE: 0.6007

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P273L	TCGA-12-5299	GBM	TCGA	VTPPGT	DEG_SCF_FBW7_1	0.7582
p.P273L	ACH-001610	Brain Cancer	CCLE	VTPPGT	DEG_SCF_FBW7_1	0.7582
p.P273Q	TCGA-43-3920	LUSC	TCGA	VTPPGT	DEG_SCF_FBW7_1	0.7035
p.P273Q	DO26445	LUSC	ICGC	VTPPGT	DEG_SCF_FBW7_1	0.7035
p.T270I	TCGA-BF-A1PX	SKCM	TCGA	VTPPGT	DEG_SCF_FBW7_1	0.75
p.T270I	DO51236	SKCM	ICGC	VTPPGT	DEG_SCF_FBW7_1	0.75
p.P273S	TCGA-D3-A5GR	SKCM	TCGA	VTPPGT	DEG_SCF_FBW7_1	0.6752
p.P274S	TCGA-EE-A3AB	SKCM	TCGA	VTPPGT	DEG_SCF_FBW7_1	0.5641
p.P274S	DO222670	MELA	ICGC	VTPPGT	DEG_SCF_FBW7_1	0.5641
p.P274S	DO38057	SKCM	ICGC	VTPPGT	DEG_SCF_FBW7_1	0.5641
p.S284Y	DO222492	COCA	ICGC	VTPPGT	DEG_SCF_FBW7_1	0.2222
p.P274L	DO234230	ESAD	ICGC	VTPPGT	DEG_SCF_FBW7_1	0.6471
p.I273M	DO233142	GACA	ICGC	VTPPGT	DEG_SCF_FBW7_1	0.7618
p.H280Y	DO233641	GACA	ICGC	VTPPGT	DEG_SCF_FBW7_1	0.2222
p.L272S	DO44440	HNSC	ICGC	VTPPGT	DEG_SCF_FBW7_1	0.7667
p.F276L	DO229029	LICA	ICGC	VTPPGT	DEG_SCF_FBW7_1	0.6981
p.F276L	DO229026	LICA	ICGC	VTPPGT	DEG_SCF_FBW7_1	0.6981
p.S282N	DO23633	LUAD	ICGC	VTPPGT	DEG_SCF_FBW7_1	0.2778
p.P265S	DO220907	MELA	ICGC	VTPPGT	DEG_SCF_FBW7_1	0.1667
p.R280K	DO51474	PACA	ICGC	VTPPGT	DEG_SCF_FBW7_1	0.2222
p.K281T	DO230589	PRAD	ICGC	VTPPGT	DEG_SCF_FBW7_1	0.3056
p.G275E	DO51298	SKCM	ICGC	VTPPGT	DEG_SCF_FBW7_1	0.6087
p.A278V	DO38475	STAD	ICGC	VTPPGT	DEG_SCF_FBW7_1	0.2778
p.A278V	SIDM02051	Colorectal Carcinoma	GDSC	VTPPGT	DEG_SCF_FBW7_1	0.2778
p.R281W	SIDM00684	Glioblastoma	GDSC	VTPPGT	DEG_SCF_FBW7_1	0.3056
p.R281W	LN-229	central_nervous_system	COSMIC	VTPPGT	DEG_SCF_FBW7_1	0.3056
p.S284F	SIDM00251	Gastric Carcinoma	GDSC	VTPPGT	DEG_SCF_FBW7_1	0.2222
p.S284F	TGBC11TKB	stomach	COSMIC	VTPPGT	DEG_SCF_FBW7_1	0.2222
p.A278T	SIDM01612	Endometrial Carcinoma	GDSC	VTPPGT	DEG_SCF_FBW7_1	0.2778
p.V268L	ACH-000250	Kidney Cancer	CCLE	VTPPGT	DEG_SCF_FBW7_1	0.25
p.V268L	KMRC-20	kidney	COSMIC	VTPPGT	DEG_SCF_FBW7_1	0.25
p.P277S	ACH-000985	Colon/Colorectal Cancer	CCLE	VTPPGT	DEG_SCF_FBW7_1	0.3056
p.P277S	LS-411N	large_intestine	COSMIC	VTPPGT	DEG_SCF_FBW7_1	0.3056
p.I267L	ACH-000987	Skin Cancer	CCLE	VTPPGT	DEG_SCF_FBW7_1	0.2222
p.I267L	Mewo	skin	COSMIC	VTPPGT	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTPPGT

Degron related mutations and impact score

Drug responses associated with KSR2 mutations

All proteins holding degron of VTPPGT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6VAB6	Kinase suppressor of Ras 2	DEG_SCF_FBW7_1	271:276	VTPPGT	FBXW7	0.9969	More...