DegronMD

Uniprot ID: Q6VAB6

Source protein: Kinase suppressor of Ras 2

Source gene: KSR2

Class: DEG_SPOP_SBC_1

Location: 515:519

E3 ligase: SPOP

DEGRON score: 0.9977

ASA_SCORE: 80.9

COIL: 0.9428

CONS_SCORE: 0.4102

DSS_SCORE: 0.7371

HELIX: 0.0386

FCONS_SCORE: 1.0929

RIG_SCORE: 0.5099

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P512R	TCGA-J4-AATZ	PRAD	TCGA	PDSSS	DEG_SPOP_SBC_1	0.25
p.H508D	TCGA-RR-A6KA	GBM	TCGA	PDSSS	DEG_SPOP_SBC_1	0.1389
p.H508D	DO51167	GBM	ICGC	PDSSS	DEG_SPOP_SBC_1	0.1389
p.S517F	TCGA-VQ-A8P2	STAD	TCGA	PDSSS	DEG_SPOP_SBC_1	0.7982
p.P513L	DO9708	COAD	ICGC	PDSSS	DEG_SPOP_SBC_1	0.2778
p.P529T	DO229045	LICA	ICGC	PDSSS	DEG_SPOP_SBC_1	0.0556
p.L507F	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	0.1111
p.L507F	TE-5	oesophagus	COSMIC	PDSSS	DEG_SPOP_SBC_1	0.1111
p.D516N	ACH-000995	Leukemia	CCLE	PDSSS	DEG_SPOP_SBC_1	0.5821
p.D516N	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PDSSS	DEG_SPOP_SBC_1	0.5821

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00507	Probable ubiquitin carboxyl-terminal hydrolase FAF-Y	DEG_SPOP_SBC_1	977:981	PDSSS	SPOP	0.9861	More...
O14981	TATA-binding protein-associated factor 172	DEG_SPOP_SBC_1	269:273	PDSSS	SPOP	0.935	More...
P02751	Fibronectin	DEG_SPOP_SBC_1	1863:1867	PDSSS	SPOP	0.902	More...
P23760	Paired box protein Pax-3	DEG_SPOP_SBC_1	348:352	PDSSS	SPOP	0.9277	More...
P28702	Retinoic acid receptor RXR-beta	DEG_SPOP_SBC_1	83:87	PDSSS	SPOP	0.9539	More...
P48553	Trafficking protein particle complex subunit 10	DEG_SPOP_SBC_1	1199:1203	PDSSS	SPOP	0.9812	More...
P56645	Period circadian protein homolog 3	DEG_SPOP_SBC_1	748:752	PDSSS	SPOP	0.8579	More...
Q12947	Forkhead box protein F2	DEG_SPOP_SBC_1	310:314	PDSSS	SPOP	0.9763	More...
Q12948	Forkhead box protein C1	DEG_SPOP_SBC_1	260:264	PDSSS	SPOP	0.9877	More...
Q14517	Protocadherin Fat 1	DEG_SPOP_SBC_1	1166:1170	PDSSS	SPOP	0.9878	More...
Q15642	Cdc42-interacting protein 4	DEG_SPOP_SBC_1	498:502	PDSSS	SPOP	0.9962	More...
Q6VAB6	Kinase suppressor of Ras 2	DEG_SPOP_SBC_1	515:519	PDSSS	SPOP	0.9977	More...
Q7LBE3	Solute carrier family 26 member 9	DEG_SPOP_SBC_1	629:633	PDSSS	SPOP	0.9618	More...
Q7Z333	Probable helicase senataxin	DEG_SPOP_SBC_1	1485:1489	PDSSS	SPOP	0.8761	More...
Q86VZ4	Low-density lipoprotein receptor-related protein 11	DEG_SPOP_SBC_1	417:421	PDSSS	SPOP	0.9592	More...
Q8N441	Fibroblast growth factor receptor-like 1	DEG_SPOP_SBC_1	129:133	PDSSS	SPOP	0.8851	More...
Q8TE77	Protein phosphatase Slingshot homolog 3	DEG_SPOP_SBC_1	152:156	PDSSS	SPOP	0.7282	More...
Q92613	Protein Jade-3	DEG_SPOP_SBC_1	567:571	PDSSS	SPOP	0.9916	More...
Q93008	Probable ubiquitin carboxyl-terminal hydrolase FAF-X	DEG_SPOP_SBC_1	976:980	PDSSS	SPOP	0.9934	More...
Q9BRK4	Leucine zipper putative tumor suppressor 2	DEG_SPOP_SBC_1	302:306	PDSSS	SPOP	0.9992	More...
Q9BWT3	Poly	DEG_SPOP_SBC_1	712:716	PDSSS	SPOP	0.9943	More...
Q9H4Z2	Zinc finger protein 335	DEG_SPOP_SBC_1	86:90	PDSSS	SPOP	0.9916	More...
Q9NWZ3	Interleukin-1 receptor-associated kinase 4	DEG_SPOP_SBC_1	148:152	PDSSS	SPOP	0.9855	More...
Q9NXG0	Centlein	DEG_SPOP_SBC_1	1396:1400	PDSSS	SPOP	0.9251	More...
Q9UPT6	C-Jun-amino-terminal kinase-interacting protein 3	DEG_SPOP_SBC_1	945:949	PDSSS	SPOP	0.9951	More...
P31267	Homeobox protein Hox-A6	DEG_SPOP_SBC_1	113:117	PDSSS	SPOP	0.545	More...
Q2T9L4	Inhibitory synaptic factor 1	DEG_SPOP_SBC_1	157:161	PDSSS	SPOP	0.9993	More...
Q5H9T9	Fibrous sheath CABYR-binding protein	DEG_SPOP_SBC_1	170:174	PDSSS	SPOP	0.9796	More...
Q8TA94	Zinc finger protein 563	DEG_SPOP_SBC_1	263:267	PDSSS	SPOP	0.9213	More...
P13985	Putative HTLV-1-related endogenous sequence	DEG_SPOP_SBC_1	139:143	PDSSS	SPOP	0.8586	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PDSSS

Degron related mutations and impact score

Drug responses associated with KSR2 mutations

All proteins holding degron of PDSSS