DegronMD - Q5H9T9(FSCB)

FUNCTION: May be involved in the later stages of fibrous sheath biogenesis and spermatozoa capacitation. Inhibits ROPN1 and ROPN1L SUMOylation. Binds calcium. {ECO:0000250|UniProtKB:A1EGX6}.

GO - Biological processes (BP): negative regulation of protein sumoylation [GO:0033234]

GO - Molecular function (MF): calcium ion binding [GO:0005509]

GO - Cellular component (CC): sperm fibrous sheath [GO:0035686]; sperm principal piece [GO:0097228]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
METPAEE	DEG_SCF_FBW7_2	FBXW7	Fibrous sheath CABYR-binding protein	446:452	More..
PKSSS	DEG_SPOP_SBC_1	SPOP	Fibrous sheath CABYR-binding protein	20:24	More..
PDSSS	DEG_SPOP_SBC_1	SPOP	Fibrous sheath CABYR-binding protein	170:174	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S22L	TCGA-DA-A3F8	SKCM	TCGA	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.7667
p.S22L	TCGA-WE-A8K5	SKCM	TCGA	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.7667
p.S22L	DO223028	ESCA	ICGC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.7667
p.S22L	DO37418	SKCM	ICGC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.7667
p.S22L	DO51282	SKCM	ICGC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.7667
p.S24I	TCGA-CR-5243	HNSC	TCGA	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.7341
p.S24I	DO14494	HNSC	ICGC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.7341
p.E452D	TCGA-17-Z058	LUAD	TCGA	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.6758
p.E452D	SIDM00282	Colorectal Carcinoma	GDSC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.6758
p.E452D	ACH-000998	Colon/Colorectal Cancer	CCLE	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.6758
p.E452D	CW-2	large intestine	COSMIC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.6758
p.S22P	TCGA-DI-A1BU	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.6752
p.S22P	DO42023	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.6752
p.E447V	TCGA-13-0911	OV	TCGA	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.6582
p.E447V	DO31553	OV	ICGC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.6582
p.M446I	TCGA-05-4432	LUAD	TCGA	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.6507
p.M446I	DO25995	LUAD	ICGC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.6507
p.A450V	DO229221	THCA	ICGC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.5825
p.A453S	TCGA-17-Z058	LUAD	TCGA	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.3056
p.T175K	TCGA-J4-AATZ	PRAD	TCGA	PDSSS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.3056

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Kaplan plot for FSCB in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

FSCB

UniProt ID: Q5H9T9

Entrez ID: 84075

Protein name: Fibrous sheath CABYR-binding protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FSCB in