DegronMD - Q5H9T9(FSCB)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M446I	TCGA-05-4432	LUAD	TCGA	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.6507
p.M446I	DO25995	LUAD	ICGC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.6507
p.E447V	TCGA-13-0911	OV	TCGA	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.6582
p.E447V	DO31553	OV	ICGC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.6582
p.A453S	TCGA-17-Z058	LUAD	TCGA	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.3056
p.E452D	TCGA-17-Z058	LUAD	TCGA	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.6758
p.E452D	SIDM00282	Colorectal Carcinoma	GDSC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.6758
p.E452D	ACH-000998	Colon/Colorectal Cancer	CCLE	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.6758
p.E452D	CW-2	large intestine	COSMIC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.6758
p.K14N	TCGA-19-5956	GBM	TCGA	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation substituting flanking lysine	0.2778
p.K14N	TCGA-EO-A22X	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation substituting flanking lysine	0.2778
p.K14N	DO13863	GBM	ICGC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation substituting flanking lysine	0.2778
p.K14N	DO43907	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation substituting flanking lysine	0.2778
p.T455N	TCGA-55-A493	LUAD	TCGA	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.25
p.T455N	DO26328	LUAD	ICGC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.25
p.I164T	TCGA-66-2787	LUSC	TCGA	PDSSS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.I164T	DO26647	LUSC	ICGC	PDSSS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.H184Q	TCGA-77-7465	LUSC	TCGA	PDSSS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.0556
p.H184Q	DO27699	LUSC	ICGC	PDSSS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.0556
p.H184Q	SIDM00699	Small Cell Lung Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.0556
p.H184Q	ACH-001138	Lung Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.0556
p.H184Q	NCI-H2141	lung	COSMIC	PDSSS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.0556
p.A181S	TCGA-AA-A010	COAD	TCGA	PDSSS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1389
p.R438Q	TCGA-AD-A5EK	COAD	TCGA	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.1111
p.R438Q	DO44089	COAD	ICGC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.1111
p.I11T	TCGA-AJ-A23O	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.0833
p.I11T	DO43290	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.0833
p.R30H	TCGA-AP-A1E0	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1667
p.R30H	TCGA-NF-A4WU	UCS	TCGA	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1667
p.R30H	DO43154	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1667
p.R30H	SIDM01577	Plasma Cell Myeloma	GDSC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1667
p.R30H	ACH-000889	Myeloma	CCLE	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1667
p.I11L	TCGA-AP-A1E0	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.0833
p.I11L	DO43154	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.0833
p.N33D	TCGA-B5-A5OC	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.0833
p.N33D	DO52405	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.0833
p.S24I	TCGA-CR-5243	HNSC	TCGA	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.7341
p.S24I	DO14494	HNSC	ICGC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.7341
p.S160I	TCGA-CR-7371	HNSC	TCGA	PDSSS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.0556
p.S160I	DO15454	HNSC	ICGC	PDSSS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.0556
p.S22L	TCGA-DA-A3F8	SKCM	TCGA	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.7667
p.S22L	TCGA-WE-A8K5	SKCM	TCGA	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.7667
p.S22L	DO223028	ESCA	ICGC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.7667
p.S22L	DO37418	SKCM	ICGC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.7667
p.S22L	DO51282	SKCM	ICGC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.7667
p.S22P	TCGA-DI-A1BU	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.6752
p.S22P	DO42023	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.6752
p.T28I	TCGA-DX-A6Z0	SARC	TCGA	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.2222
p.T28I	DO220017	SARC	ICGC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.2222
p.H29N	TCGA-FD-A3N6	BLCA	TCGA	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1944
p.H29N	DO575	BLCA	ICGC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1944
p.P462H	TCGA-FS-A1ZG	SKCM	TCGA	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.0556
p.P462H	TCGA-GL-6846	KIRP	TCGA	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.0556
p.P462H	DO20808	KIRP	ICGC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.0556
p.P462H	DO37523	SKCM	ICGC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.0556
p.E179K	TCGA-FW-A3R5	SKCM	TCGA	PDSSS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1944
p.E179K	DO37406	SKCM	ICGC	PDSSS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1944
p.I11K	TCGA-GS-A9TV	DLBC	TCGA	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.0833
p.I11K	DO219914	DLBC	ICGC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.0833
p.R30C	TCGA-HM-A6W2	CESC	TCGA	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1667
p.R30C	DO48999	CESC	ICGC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1667
p.L440R	TCGA-IC-A6RE	ESCA	TCGA	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.1667
p.T175K	TCGA-J4-AATZ	PRAD	TCGA	PDSSS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.3056
p.T175K	DO219261	PRAD	ICGC	PDSSS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.3056
p.H16Q	TCGA-WK-A8Y0	SARC	TCGA	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.2222
p.H16Q	DO220305	SARC	ICGC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.2222
p.E456Q	DO223560	CLLE	ICGC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.2222
p.A27P	DO234377	ESAD	ICGC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.25
p.S160R	DO234441	ESAD	ICGC	PDSSS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.0556
p.A181D	DO229019	LICA	ICGC	PDSSS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1389
p.T444K	DO229037	LICA	ICGC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.2778
p.P454L	DO229275	THCA	ICGC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.2778
p.A450V	DO229221	THCA	ICGC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.5825
p.R438G	SIDM00672	Hepatocellular Carcinoma	GDSC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.1111
p.R438G	SIDM00254	Neuroblastoma	GDSC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.1111
p.R438G	SIDM00875	Breast Carcinoma	GDSC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.1111
p.R438G	SIDM00954	Breast Carcinoma	GDSC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.1111
p.M17I	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.25
p.M17I	ACH-000983	Leukemia	CCLE	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.25
p.M17I	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.25
p.A18S	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.2778
p.A18S	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.2778
p.Q458E	SIDM00025	Head and Neck Carcinoma	GDSC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.1667
p.Q458E	ACH-002391	Head and Neck Cancer	CCLE	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.1667
p.Q458E	UDSCC2	upper aerodigestive tract	COSMIC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.1667
p.E436D	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.0556
p.E436D	ACH-000852	Lung Cancer	CCLE	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.0556
p.E436D	NCI-H1435	lung	COSMIC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.0556
p.D180V	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.D180V	ACH-000869	Lung Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.D180V	NCI-H1568	lung	COSMIC	PDSSS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.A18T	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.2778
p.A18T	ACH-001498	Lymphoma	CCLE	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.2778
p.A18T	Farage	haematopoietic and lymphoid tissue	COSMIC	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.2778
p.S459P	SIDM01378	Ovarian Carcinoma	GDSC	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.1389
p.S459P	ACH-000646	Ovarian Cancer	CCLE	METPAEE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.1389
p.17_18MA>IS	ACH-000983	Leukemia	CCLE	PKSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FSCB

UniProt ID: Q5H9T9

Entrez ID: 84075

Protein name: Fibrous sheath CABYR-binding protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FSCB in