DegronMD

Uniprot ID: Q5H9T9

Source protein: Fibrous sheath CABYR-binding protein

Source gene: FSCB

Class: DEG_SPOP_SBC_1

Location: 20:24

E3 ligase: SPOP

DEGRON score: 0.8424

ASA_SCORE: 98.76

COIL: 0.9494

CONS_SCORE: 0.5452

DSS_SCORE: 0.6905

HELIX: 0.0212

FCONS_SCORE: 0.7539

RIG_SCORE: 0.6321

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K14N	TCGA-19-5956	GBM	TCGA	PKSSS	DEG_SPOP_SBC_1	0.2778
p.K14N	TCGA-EO-A22X	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	0.2778
p.K14N	DO13863	GBM	ICGC	PKSSS	DEG_SPOP_SBC_1	0.2778
p.K14N	DO43907	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.2778
p.I11T	TCGA-AJ-A23O	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	0.0833
p.I11T	DO43290	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.0833
p.R30H	TCGA-AP-A1E0	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	0.1667
p.R30H	TCGA-NF-A4WU	UCS	TCGA	PKSSS	DEG_SPOP_SBC_1	0.1667
p.R30H	DO43154	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.1667
p.R30H	SIDM01577	Plasma Cell Myeloma	GDSC	PKSSS	DEG_SPOP_SBC_1	0.1667
p.R30H	ACH-000889	Myeloma	CCLE	PKSSS	DEG_SPOP_SBC_1	0.1667
p.I11L	TCGA-AP-A1E0	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	0.0833
p.I11L	DO43154	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.0833
p.N33D	TCGA-B5-A5OC	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	0.0833
p.N33D	DO52405	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.0833
p.S24I	TCGA-CR-5243	HNSC	TCGA	PKSSS	DEG_SPOP_SBC_1	0.7341
p.S24I	DO14494	HNSC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.7341
p.S22L	TCGA-DA-A3F8	SKCM	TCGA	PKSSS	DEG_SPOP_SBC_1	0.7667
p.S22L	TCGA-WE-A8K5	SKCM	TCGA	PKSSS	DEG_SPOP_SBC_1	0.7667
p.S22L	DO223028	ESCA	ICGC	PKSSS	DEG_SPOP_SBC_1	0.7667
p.S22L	DO37418	SKCM	ICGC	PKSSS	DEG_SPOP_SBC_1	0.7667
p.S22L	DO51282	SKCM	ICGC	PKSSS	DEG_SPOP_SBC_1	0.7667
p.S22P	TCGA-DI-A1BU	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	0.6752
p.S22P	DO42023	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.6752
p.T28I	TCGA-DX-A6Z0	SARC	TCGA	PKSSS	DEG_SPOP_SBC_1	0.2222
p.T28I	DO220017	SARC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.2222
p.H29N	TCGA-FD-A3N6	BLCA	TCGA	PKSSS	DEG_SPOP_SBC_1	0.1944
p.H29N	DO575	BLCA	ICGC	PKSSS	DEG_SPOP_SBC_1	0.1944
p.I11K	TCGA-GS-A9TV	DLBC	TCGA	PKSSS	DEG_SPOP_SBC_1	0.0833
p.I11K	DO219914	DLBC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.0833
p.R30C	TCGA-HM-A6W2	CESC	TCGA	PKSSS	DEG_SPOP_SBC_1	0.1667
p.R30C	DO48999	CESC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.1667
p.H16Q	TCGA-WK-A8Y0	SARC	TCGA	PKSSS	DEG_SPOP_SBC_1	0.2222
p.H16Q	DO220305	SARC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.2222
p.A27P	DO234377	ESAD	ICGC	PKSSS	DEG_SPOP_SBC_1	0.25
p.M17I	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PKSSS	DEG_SPOP_SBC_1	0.25
p.M17I	ACH-000983	Leukemia	CCLE	PKSSS	DEG_SPOP_SBC_1	0.25
p.M17I	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PKSSS	DEG_SPOP_SBC_1	0.25
p.A18S	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PKSSS	DEG_SPOP_SBC_1	0.2778
p.A18S	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PKSSS	DEG_SPOP_SBC_1	0.2778
p.A18T	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	PKSSS	DEG_SPOP_SBC_1	0.2778
p.A18T	ACH-001498	Lymphoma	CCLE	PKSSS	DEG_SPOP_SBC_1	0.2778
p.A18T	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	PKSSS	DEG_SPOP_SBC_1	0.2778
p.17_18MA>IS	ACH-000983	Leukemia	CCLE	PKSSS	DEG_SPOP_SBC_1	0

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15085	Rho guanine nucleotide exchange factor 11	DEG_SPOP_SBC_1	543:547	PKSSS	SPOP	0.7465	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1015:1019	PKSSS	SPOP	0.8719	More...
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	564:568	PKSSS	SPOP	0.9922	More...
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	289:293	PKSSS	SPOP	0.9956	More...
Q15811	Intersectin-1	DEG_SPOP_SBC_1	180:184	PKSSS	SPOP	0.9976	More...
Q5T200	Zinc finger CCCH domain-containing protein 13	DEG_SPOP_SBC_1	225:229	PKSSS	SPOP	0.9834	More...
Q5TCZ1	SH3 and PX domain-containing protein 2A	DEG_SPOP_SBC_1	663:667	PKSSS	SPOP	0.8452	More...
Q6DN12	Multiple C2 and transmembrane domain-containing protein 2	DEG_SPOP_SBC_1	89:93	PKSSS	SPOP	0.7468	More...
Q7L590	Protein MCM10 homolog	DEG_SPOP_SBC_1	200:204	PKSSS	SPOP	0.9805	More...
Q8N3F8	MICAL-like protein 1	DEG_SPOP_SBC_1	534:538	PKSSS	SPOP	0.9952	More...
Q8WYP5	Protein ELYS	DEG_SPOP_SBC_1	1340:1344	PKSSS	SPOP	0.9617	More...
Q96QS3	Homeobox protein ARX	DEG_SPOP_SBC_1	68:72	PKSSS	SPOP	0.583	More...
Q9NXV6	CDKN2A-interacting protein	DEG_SPOP_SBC_1	347:351	PKSSS	SPOP	0.9905	More...
Q9Y2I7	1-phosphatidylinositol 3-phosphate 5-kinase	DEG_SPOP_SBC_1	1710:1714	PKSSS	SPOP	0.9961	More...
Q9Y5X1	Sorting nexin-9	DEG_SPOP_SBC_1	172:176	PKSSS	SPOP	0.9854	More...
A6NHQ2	rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1	DEG_SPOP_SBC_1	329:333	PKSSS	SPOP	0.72	More...
A7E2F4	Golgin subfamily A member 8A	DEG_SPOP_SBC_1	83:87	PKSSS	SPOP	0.7895	More...
Q5H9T9	Fibrous sheath CABYR-binding protein	DEG_SPOP_SBC_1	20:24	PKSSS	SPOP	0.8424	More...
Q5JSZ5	Protein PRRC2B	DEG_SPOP_SBC_1	96:100	PKSSS	SPOP	0.8516	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	544:548	PKSSS	SPOP	0.9953	More...
Q9BX69	Caspase recruitment domain-containing protein 6	DEG_SPOP_SBC_1	1012:1016	PKSSS	SPOP	0.9263	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	434:438	PKSSS	SPOP	0.9775	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKSSS

Degron related mutations and impact score

Drug responses associated with FSCB mutations

All proteins holding degron of PKSSS