DegronMD - Q6DN12(MCTP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T84A	TCGA-BJ-A4O8	THCA	TCGA	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1944
p.T84A	DO48066	THCA	ICGC	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1944
p.G86E	TCGA-EE-A29D	SKCM	TCGA	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.25
p.G86E	DO38123	SKCM	ICGC	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.25
p.S91R	TCGA-EP-A2KC	LIHC	TCGA	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.7427
p.S91R	DO22966	LIHC	ICGC	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.7427
p.G10D	TCGA-IB-7651	PAAD	TCGA	TRPLLINLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.1667
p.G10D	DO46657	PAAD	ICGC	TRPLLINLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.1667
p.R83Q	DO223586	CLLE	ICGC	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1667
p.R83Q	DO37814	SKCM	ICGC	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1667
p.G97S	DO10212	COAD	ICGC	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation substituting flanking lysine	0.3333
p.G97S	DO9876	COAD	ICGC	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation substituting flanking lysine	0.3333
p.G97S	DO42713	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation substituting flanking lysine	0.3333
p.R15Q	DO233002	GACA	ICGC	TRPLLINLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.3056
p.D12V	DO14284	HNSC	ICGC	TRPLLINLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.2222
p.L20F	DO228948	LICA	ICGC	TRPLLINLS	DEG_APCC_DBOX_1	16:24	Mutation altering degron motif	0.6981
p.K33N	DO228971	LICA	ICGC	TRPLLINLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.0833
p.P31S	DO232034	LICA	ICGC	TRPLLINLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.1389
p.D26Y	DO229015	LICA	ICGC	TRPLLINLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.2778
p.V93L	DO229034	LICA	ICGC	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.6765
p.E17Q	DO22857	LIHC	ICGC	TRPLLINLS	DEG_APCC_DBOX_1	16:24	Mutation altering degron motif	0.6744
p.E17Q	DO22896	LIHC	ICGC	TRPLLINLS	DEG_APCC_DBOX_1	16:24	Mutation altering degron motif	0.6744
p.V101M	DO52318	LIHC	ICGC	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1111
p.K11N	DO219535	LIHC	ICGC	TRPLLINLS	DEG_APCC_DBOX_1	16:24	Mutation blocking phosphorylation signal	0.6389
p.V96F	DO26790	LUSC	ICGC	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.25
p.P89S	DO220894	MELA	ICGC	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.6752
p.P89S	DO220912	MELA	ICGC	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.6752
p.L82V	DO229066	PRAD	ICGC	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1389
p.H16R	DO38723	STAD	ICGC	TRPLLINLS	DEG_APCC_DBOX_1	16:24	Mutation altering degron motif	0.8244
p.L90P	DO51795	STAD	ICGC	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.7582
p.S28L	DO43186	UCEC	ICGC	TRPLLINLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.2222
p.S93N	SIDM00600	Thyroid Gland Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.7069
p.S93N	ACH-001528	Thyroid Cancer	CCLE	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.7069
p.S93N	IHH-4	thyroid	COSMIC	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.7069
p.S7P	SIDM00928	Breast Carcinoma	GDSC	TRPLLINLS	DEG_APCC_DBOX_1	16:24	Mutation substituting flanking lysine	0.1944
p.S7P	CAL-85-1	breast	COSMIC	TRPLLINLS	DEG_APCC_DBOX_1	16:24	Mutation substituting flanking lysine	0.1944
p.S80R	SIDM00538	Esophageal Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation blocking phosphorylation signal	0.5278
p.S80R	ESO51	oesophagus	COSMIC	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation blocking phosphorylation signal	0.5278
p.S33R	SIDM00238	Ovarian Carcinoma	GDSC	TRPLLINLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.0833
p.S33R	ACH-000947	Ovarian Cancer	CCLE	TRPLLINLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.0833
p.S33R	OVK-18	ovary	COSMIC	TRPLLINLS	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.0833
p.P79H	SIDM00585	Hepatocellular Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.0556
p.P79H	ACH-000480	Liver Cancer	CCLE	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.0556
p.P79H	HuH-7	liver	COSMIC	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.0556
p.S81N	SIDM00387	Neuroblastoma	GDSC	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1111
p.S81N	MHH-NB-11	autonomic ganglia	COSMIC	PKSSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1111
p.R19H	CAS-1	central nervous system	COSMIC	TRPLLINLS	DEG_APCC_DBOX_1	16:24	Mutation altering degron motif	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MCTP2

UniProt ID: Q6DN12

Entrez ID: 55784

Protein name: Multiple C2 and transmembrane domain-containing protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MCTP2 in