DegronMD

Uniprot ID: Q6DN12

Source protein: Multiple C2 and transmembrane domain-containing protein 2

Source gene: MCTP2

Class: DEG_APCC_DBOX_1

Location: 16:24

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9897

ASA_SCORE: 78.1889

COIL: 0.4839

CONS_SCORE: 0.3581

DSS_SCORE: 0.5408

HELIX: 0.4928

FCONS_SCORE: 0.9865

RIG_SCORE: 0.773

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G10D	TCGA-IB-7651	PAAD	TCGA	TRPLLINLS	DEG_APCC_DBOX_1	0.1667
p.G10D	DO46657	PAAD	ICGC	TRPLLINLS	DEG_APCC_DBOX_1	0.1667
p.R15Q	DO233002	GACA	ICGC	TRPLLINLS	DEG_APCC_DBOX_1	0.3056
p.D12V	DO14284	HNSC	ICGC	TRPLLINLS	DEG_APCC_DBOX_1	0.2222
p.L20F	DO228948	LICA	ICGC	TRPLLINLS	DEG_APCC_DBOX_1	0.6981
p.K33N	DO228971	LICA	ICGC	TRPLLINLS	DEG_APCC_DBOX_1	0.0833
p.P31S	DO232034	LICA	ICGC	TRPLLINLS	DEG_APCC_DBOX_1	0.1389
p.D26Y	DO229015	LICA	ICGC	TRPLLINLS	DEG_APCC_DBOX_1	0.2778
p.E17Q	DO22857	LIHC	ICGC	TRPLLINLS	DEG_APCC_DBOX_1	0.6744
p.E17Q	DO22896	LIHC	ICGC	TRPLLINLS	DEG_APCC_DBOX_1	0.6744
p.K11N	DO219535	LIHC	ICGC	TRPLLINLS	DEG_APCC_DBOX_1	0.6389
p.H16R	DO38723	STAD	ICGC	TRPLLINLS	DEG_APCC_DBOX_1	0.8244
p.S28L	DO43186	UCEC	ICGC	TRPLLINLS	DEG_APCC_DBOX_1	0.2222
p.S7P	SIDM00928	Breast Carcinoma	GDSC	TRPLLINLS	DEG_APCC_DBOX_1	0.1944
p.S7P	CAL-85-1	breast	COSMIC	TRPLLINLS	DEG_APCC_DBOX_1	0.1944
p.S33R	SIDM00238	Ovarian Carcinoma	GDSC	TRPLLINLS	DEG_APCC_DBOX_1	0.0833
p.S33R	ACH-000947	Ovarian Cancer	CCLE	TRPLLINLS	DEG_APCC_DBOX_1	0.0833
p.S33R	OVK-18	ovary	COSMIC	TRPLLINLS	DEG_APCC_DBOX_1	0.0833
p.R19H	CAS-1	central_nervous_system	COSMIC	TRPLLINLS	DEG_APCC_DBOX_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6DN12	Multiple C2 and transmembrane domain-containing protein 2	DEG_APCC_DBOX_1	16:24	TRPLLINLS	APC,CDC20,FZR1	0.9897	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons