DegronMD - Q8N3F8(MICALL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P641H	TCGA-06-2566	GBM	TCGA	CKENP	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.1389
p.P641H	DO11507	GBM	ICGC	CKENP	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.1389
p.S536R	TCGA-28-1760	GBM	TCGA	PKSSS	DEG_SPOP_SBC_1	534:538	Mutation altering degron motif	0.7427
p.S536R	DO13725	GBM	ICGC	PKSSS	DEG_SPOP_SBC_1	534:538	Mutation altering degron motif	0.7427
p.T456A	TCGA-2W-A8YY	CESC	TCGA	ITPTSS	DEG_SCF_FBW7_1	466:471	Mutation rewiring degron network	0.0556
p.T456A	DO223732	CESC	ICGC	ITPTSS	DEG_SCF_FBW7_1	466:471	Mutation rewiring degron network	0.0556
p.R477C	TCGA-77-A5GF	LUSC	TCGA	ITPTSS	DEG_SCF_FBW7_1	466:471	Mutation rewiring degron network	0.1667
p.R477C	DO50101	LUSC	ICGC	ITPTSS	DEG_SCF_FBW7_1	466:471	Mutation rewiring degron network	0.1667
p.R477C	SIDM00216	Colorectal Carcinoma	GDSC	ITPTSS	DEG_SCF_FBW7_1	466:471	Mutation rewiring degron network	0.1667
p.P530L	TCGA-85-6798	LUSC	TCGA	PKSSS	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.2222
p.P530L	DO233884	GACA	ICGC	PKSSS	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.2222
p.P530L	DO27295	LUSC	ICGC	PKSSS	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.2222
p.P548S	TCGA-90-A4ED	LUSC	TCGA	PKSSS	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.0556
p.P548S	DO45482	LUSC	ICGC	PKSSS	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.0556
p.P548L	TCGA-90-A4ED	LUSC	TCGA	PKSSS	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.0556
p.P548L	DO45482	LUSC	ICGC	PKSSS	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.0556
p.A643E	TCGA-AA-A01C	COAD	TCGA	CKENP	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.0833
p.A643E	DO7781	COAD	ICGC	CKENP	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.0833
p.K380N	TCGA-AJ-A3EL	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	387:391	Mutation substituting flanking lysine	0.25
p.K380N	DO41542	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	387:391	Mutation substituting flanking lysine	0.25
p.P613Q	TCGA-CN-6010	HNSC	TCGA	PGSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.2222
p.P613Q	TCGA-G7-6797	KIRP	TCGA	PGSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.2222
p.P613Q	DO14766	HNSC	ICGC	PGSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.2222
p.P613Q	DO20917	KIRP	ICGC	PGSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.2222
p.S620L	TCGA-DK-AA75	BLCA	TCGA	PGSSS	DEG_SPOP_SBC_1	617:621	Mutation altering degron motif	0.8778
p.S620L	DO219012	BLCA	ICGC	PGSSS	DEG_SPOP_SBC_1	617:621	Mutation altering degron motif	0.8778
p.S620L	SIDM02013	Colorectal Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	617:621	Mutation altering degron motif	0.8778
p.P478H	TCGA-DU-7298	LGG	TCGA	ITPTSS	DEG_SCF_FBW7_1	466:471	Mutation rewiring degron network	0.1389
p.P478H	DO22679	LGG	ICGC	ITPTSS	DEG_SCF_FBW7_1	466:471	Mutation rewiring degron network	0.1389
p.G546C	TCGA-EE-A181	SKCM	TCGA	PKSSS	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.1111
p.G546C	DO37444	SKCM	ICGC	PKSSS	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.1111
p.H543Y	TCGA-EE-A2MD	SKCM	TCGA	PKSSS	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.1944
p.H543Y	DO222434	MELA	ICGC	PKSSS	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.1944
p.H543Y	DO37851	SKCM	ICGC	PKSSS	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.1944
p.P462S	TCGA-ER-A19F	SKCM	TCGA	ITPTSS	DEG_SCF_FBW7_1	466:471	Mutation rewiring degron network	0.2222
p.P462S	DO37679	SKCM	ICGC	ITPTSS	DEG_SCF_FBW7_1	466:471	Mutation rewiring degron network	0.2222
p.P617S	TCGA-FS-A1ZM	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	617:621	Mutation altering degron motif	0.6752
p.P617S	DO37731	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	617:621	Mutation altering degron motif	0.6752
p.S538L	TCGA-HQ-A5NE	BLCA	TCGA	PKSSS	DEG_SPOP_SBC_1	534:538	Mutation altering degron motif	0.7667
p.S538L	DO51900	BLCA	ICGC	PKSSS	DEG_SPOP_SBC_1	534:538	Mutation altering degron motif	0.7667
p.R481H	TCGA-HU-A4GX	STAD	TCGA	ITPTSS	DEG_SCF_FBW7_1	466:471	Mutation rewiring degron network	0.0556
p.R481H	DO233206	GACA	ICGC	ITPTSS	DEG_SCF_FBW7_1	466:471	Mutation rewiring degron network	0.0556
p.R481H	DO47757	STAD	ICGC	ITPTSS	DEG_SCF_FBW7_1	466:471	Mutation rewiring degron network	0.0556
p.P480L	TCGA-VQ-A8P5	STAD	TCGA	ITPTSS	DEG_SCF_FBW7_1	466:471	Mutation rewiring degron network	0.0833
p.P480L	DO51763	STAD	ICGC	ITPTSS	DEG_SCF_FBW7_1	466:471	Mutation rewiring degron network	0.0833
p.W463C	DO48451	BLCA	ICGC	ITPTSS	DEG_SCF_FBW7_1	466:471	Mutation rewiring degron network	0.25
p.W463C	DO229031	LICA	ICGC	ITPTSS	DEG_SCF_FBW7_1	466:471	Mutation rewiring degron network	0.25
p.E346G	DO227709	COCA	ICGC	PRGTPKPS	DEG_SCF_FBW7_1	352:359	Mutation rewiring degron network	0.1667
p.E346G	DO227709	COCA	ICGC	AGSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1111
p.P480Q	DO227657	COCA	ICGC	ITPTSS	DEG_SCF_FBW7_1	466:471	Mutation rewiring degron network	0.0833
p.E632D	DO222762	COCA	ICGC	CKENP	DEG_APCC_KENBOX_2	630:634	Mutation altering degron motif	0.6758
p.P392L	DO233245	GACA	ICGC	PPSSS	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.3056
p.C630F	DO228948	LICA	ICGC	CKENP	DEG_APCC_KENBOX_2	630:634	Mutation altering degron motif	0.5996
p.E360D	DO228978	LICA	ICGC	PRGTPKPS	DEG_SCF_FBW7_1	352:359	Mutation rewiring degron network	0.3056
p.A541S	DO228986	LICA	ICGC	PKSSS	DEG_SPOP_SBC_1	534:538	Mutation rewiring degron network	0.25
p.P394L	DO232024	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.25
p.Q625H	DO229015	LICA	ICGC	CKENP	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.1944
p.Q625H	DO229015	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.2222
p.Q397H	DO229035	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.1667
p.S537F	DO229063	LICA	ICGC	PKSSS	DEG_SPOP_SBC_1	534:538	Mutation altering degron motif	0.7982
p.G335S	DO50970	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.5882
p.S470I	DO50917	LICA	ICGC	ITPTSS	DEG_SCF_FBW7_1	466:471	Mutation altering degron motif	0.7341
p.P472L	DO50727	ORCA	ICGC	ITPTSS	DEG_SCF_FBW7_1	466:471	Mutation rewiring degron network	0.3056
p.S644P	DO218849	SKCA	ICGC	CKENP	DEG_APCC_KENBOX_2	630:634	Mutation blocking phosphorylation signal	0.5
p.G342R	DO229121	THCA	ICGC	PRGTPKPS	DEG_SCF_FBW7_1	352:359	Mutation rewiring degron network	0.0556
p.G342R	DO229121	THCA	ICGC	AGSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.2222
p.S616F	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PGSSS	DEG_SPOP_SBC_1	617:621	Mutation blocking phosphorylation signal	0.75
p.S616F	ACH-000983	Leukemia	CCLE	PGSSS	DEG_SPOP_SBC_1	617:621	Mutation blocking phosphorylation signal	0.75
p.S616F	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PGSSS	DEG_SPOP_SBC_1	617:621	Mutation blocking phosphorylation signal	0.75
p.R353K	SIDM00625	Other Sarcomas	GDSC	PRGTPKPS	DEG_SCF_FBW7_1	352:359	Mutation altering degron motif	0.6126
p.R353K	ACH-000449	Sarcoma	CCLE	PRGTPKPS	DEG_SCF_FBW7_1	352:359	Mutation altering degron motif	0.6126
p.R353K	MES-SA	soft tissue	COSMIC	PRGTPKPS	DEG_SCF_FBW7_1	352:359	Mutation altering degron motif	0.6126
p.P350S	SIDM01878	Non-Cancerous	GDSC	PRGTPKPS	DEG_SCF_FBW7_1	352:359	Mutation rewiring degron network	0.2778
p.P350S	SIDM00053	Pancreatic Carcinoma	GDSC	PRGTPKPS	DEG_SCF_FBW7_1	352:359	Mutation rewiring degron network	0.2778
p.P350S	ACH-002360	Non-Cancerous	CCLE	PRGTPKPS	DEG_SCF_FBW7_1	352:359	Mutation rewiring degron network	0.2778
p.L344R	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRGTPKPS	DEG_SCF_FBW7_1	352:359	Mutation rewiring degron network	0.1111
p.L344R	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	AGSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1667
p.L344R	SIDM01526	Mesothelioma	GDSC	PRGTPKPS	DEG_SCF_FBW7_1	352:359	Mutation rewiring degron network	0.1111
p.L344R	SIDM01526	Mesothelioma	GDSC	AGSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1667
p.L344R	JEKO-1	haematopoietic and lymphoid tissue	COSMIC	PRGTPKPS	DEG_SCF_FBW7_1	352:359	Mutation rewiring degron network	0.1111
p.L344R	JEKO-1	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1667
p.R637Q	SIDM00871	Non-Cancerous	GDSC	CKENP	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.25
p.R637Q	SIDM00872	Breast Carcinoma	GDSC	CKENP	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.25
p.V626L	SIDM00710	Small Cell Lung Carcinoma	GDSC	CKENP	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.2222
p.V626L	SIDM00710	Small Cell Lung Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1944
p.V626L	ACH-000394	Lung Cancer	CCLE	CKENP	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.2222
p.V626L	ACH-000394	Lung Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1944
p.V626L	NCI-H2081	lung	COSMIC	CKENP	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.2222
p.V626L	NCI-H2081	lung	COSMIC	PGSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1944
p.R477H	SIDM00980	Gastric Carcinoma	GDSC	ITPTSS	DEG_SCF_FBW7_1	466:471	Mutation rewiring degron network	0.1667
p.R477H	ACH-000948	Gastric Cancer	CCLE	ITPTSS	DEG_SCF_FBW7_1	466:471	Mutation rewiring degron network	0.1667
p.R477H	23132-87	stomach	COSMIC	ITPTSS	DEG_SCF_FBW7_1	466:471	Mutation rewiring degron network	0.1667
p.R611K	SIDM01765	Osteosarcoma	GDSC	PGSSS	DEG_SPOP_SBC_1	617:621	Mutation rewiring degron network	0.1667
p.E378G	ACH-000039	Bone Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.0833
p.E378G	ACH-002160	Bone Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.0833
p.E378G	MC-IXC	autonomic ganglia	COSMIC	PPSSS	DEG_SPOP_SBC_1	387:391	Mutation rewiring degron network	0.0833
p.S470N	ACH-001377	Pancreatic Cancer	CCLE	ITPTSS	DEG_SCF_FBW7_1	466:471	Mutation altering degron motif	0.7069
p.S616T	ACH-001569	Skin Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	617:621	Mutation blocking phosphorylation signal	0.75

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MICALL1

UniProt ID: Q8N3F8

Entrez ID: 85377

Protein name: MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MICALL1 in