DegronMD

Uniprot ID: Q8N3F8

Source protein: MICAL-like protein 1

Source gene: MICALL1

Class: DEG_APCC_KENBOX_2

Location: 630:634

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9989

ASA_SCORE: 95.38

COIL: 0.8322

CONS_SCORE: 0.4706

DSS_SCORE: 0.6839

HELIX: 0.1562

FCONS_SCORE: 1.246

RIG_SCORE: 0.6274

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P641H	TCGA-06-2566	GBM	TCGA	CKENP	DEG_APCC_KENBOX_2	0.1389
p.P641H	DO11507	GBM	ICGC	CKENP	DEG_APCC_KENBOX_2	0.1389
p.A643E	TCGA-AA-A01C	COAD	TCGA	CKENP	DEG_APCC_KENBOX_2	0.0833
p.A643E	DO7781	COAD	ICGC	CKENP	DEG_APCC_KENBOX_2	0.0833
p.E632D	DO222762	COCA	ICGC	CKENP	DEG_APCC_KENBOX_2	0.6758
p.C630F	DO228948	LICA	ICGC	CKENP	DEG_APCC_KENBOX_2	0.5996
p.Q625H	DO229015	LICA	ICGC	CKENP	DEG_APCC_KENBOX_2	0.1944
p.S644P	DO218849	SKCA	ICGC	CKENP	DEG_APCC_KENBOX_2	0.5
p.R637Q	SIDM00871	Non-Cancerous	GDSC	CKENP	DEG_APCC_KENBOX_2	0.25
p.R637Q	SIDM00872	Breast Carcinoma	GDSC	CKENP	DEG_APCC_KENBOX_2	0.25
p.V626L	SIDM00710	Small Cell Lung Carcinoma	GDSC	CKENP	DEG_APCC_KENBOX_2	0.2222
p.V626L	ACH-000394	Lung Cancer	CCLE	CKENP	DEG_APCC_KENBOX_2	0.2222
p.V626L	NCI-H2081	lung	COSMIC	CKENP	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3F8	MICAL-like protein 1	DEG_APCC_KENBOX_2	630:634	CKENP	APC,CDC20,FZR1	0.9989	More...
Q96SN8	CDK5 regulatory subunit-associated protein 2	DEG_APCC_KENBOX_2	1065:1069	CKENP	APC,CDC20,FZR1	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons