DegronMD

Uniprot ID: Q96SN8

Source protein: CDK5 regulatory subunit-associated protein 2

Source gene: CDK5RAP2

Class: DEG_APCC_KENBOX_2

Location: 1065:1069

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9992

ASA_SCORE: 96.84

COIL: 0.7836

CONS_SCORE: 0.4169

DSS_SCORE: 0.5669

HELIX: 0.1952

FCONS_SCORE: 1.2103

RIG_SCORE: 0.668

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1061N	TCGA-2W-A8YY	CESC	TCGA	CKENP	DEG_APCC_KENBOX_2	0.6667
p.S1061N	DO223732	CESC	ICGC	CKENP	DEG_APCC_KENBOX_2	0.6667
p.N1068K	TCGA-AP-A1DQ	UCEC	TCGA	CKENP	DEG_APCC_KENBOX_2	0.6918
p.N1068K	DO41259	UCEC	ICGC	CKENP	DEG_APCC_KENBOX_2	0.6918
p.S1077A	TCGA-E6-A1M0	UCEC	TCGA	CKENP	DEG_APCC_KENBOX_2	0.5556
p.S1077A	DO43682	UCEC	ICGC	CKENP	DEG_APCC_KENBOX_2	0.5556
p.S1077L	DO50727	ORCA	ICGC	CKENP	DEG_APCC_KENBOX_2	0.5556
p.P1069T	SIDM02021	Esophageal Carcinoma	GDSC	CKENP	DEG_APCC_KENBOX_2	0.5919
p.P1069T	SIDM00481	Ovarian Carcinoma	GDSC	CKENP	DEG_APCC_KENBOX_2	0.5919
p.P1069T	ACH-000116	Ovarian Cancer	CCLE	CKENP	DEG_APCC_KENBOX_2	0.5919
p.P1069T	OAW-28	ovary	COSMIC	CKENP	DEG_APCC_KENBOX_2	0.5919
p.L1059I	SIDM00789	Colorectal Carcinoma	GDSC	CKENP	DEG_APCC_KENBOX_2	0.1667
p.L1059I	ACH-000997	Colon/Colorectal Cancer	CCLE	CKENP	DEG_APCC_KENBOX_2	0.1667
p.L1059I	HCT-15	large_intestine	COSMIC	CKENP	DEG_APCC_KENBOX_2	0.1667
p.A1076V	HCC-15	lung	COSMIC	CKENP	DEG_APCC_KENBOX_2	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3F8	MICAL-like protein 1	DEG_APCC_KENBOX_2	630:634	CKENP	APC,CDC20,FZR1	0.9989	More...
Q96SN8	CDK5 regulatory subunit-associated protein 2	DEG_APCC_KENBOX_2	1065:1069	CKENP	APC,CDC20,FZR1	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons