DegronMD - Q96SN8(CDK5RAP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1235K	TCGA-06-5416	GBM	TCGA	PPRY	ITCH	1239:1242	Mutation rewiring degron network	0.2222
p.R1235K	DO10880	GBM	ICGC	PPRY	ITCH	1239:1242	Mutation rewiring degron network	0.2222
p.E8G	TCGA-12-0775	GBM	TCGA	SGCSGLVPSV	DEG_COP1_1	17:26	Mutation rewiring degron network	0.0833
p.E8G	DO14133	GBM	ICGC	SGCSGLVPSV	DEG_COP1_1	17:26	Mutation rewiring degron network	0.0833
p.G1469V	TCGA-24-2293	OV	TCGA	QKEND	DEG_APCC_KENBOX_2	1474:1478	Mutation rewiring degron network	0.1944
p.G1469V	DO28005	OV	ICGC	QKEND	DEG_APCC_KENBOX_2	1474:1478	Mutation rewiring degron network	0.1944
p.D1243N	TCGA-2W-A8YY	CESC	TCGA	PPRY	ITCH	1239:1242	Mutation rewiring degron network	0.3056
p.D1243N	DO223732	CESC	ICGC	PPRY	ITCH	1239:1242	Mutation rewiring degron network	0.3056
p.S1061N	TCGA-2W-A8YY	CESC	TCGA	CKENP	DEG_APCC_KENBOX_2	1065:1069	Mutation blocking phosphorylation signal	0.6667
p.S1061N	DO223732	CESC	ICGC	CKENP	DEG_APCC_KENBOX_2	1065:1069	Mutation blocking phosphorylation signal	0.6667
p.P1012H	TCGA-AP-A1DP	UCEC	TCGA	PTPDKT	DEG_SCF_FBW7_1	1000:1005	Mutation rewiring degron network	0.1389
p.P1012H	DO42336	UCEC	ICGC	PTPDKT	DEG_SCF_FBW7_1	1000:1005	Mutation rewiring degron network	0.1389
p.N1068K	TCGA-AP-A1DQ	UCEC	TCGA	CKENP	DEG_APCC_KENBOX_2	1065:1069	Mutation altering degron motif	0.6918
p.N1068K	DO41259	UCEC	ICGC	CKENP	DEG_APCC_KENBOX_2	1065:1069	Mutation altering degron motif	0.6918
p.E790D	TCGA-AX-A05Z	UCEC	TCGA	LAPLFNEKATLLL	DEG_ODPH_VHL_1	777:789	Mutation rewiring degron network	0.3056
p.E790D	DO40884	UCEC	ICGC	LAPLFNEKATLLL	DEG_ODPH_VHL_1	777:789	Mutation rewiring degron network	0.3056
p.D1698N	TCGA-B5-A3FA	UCEC	TCGA	DSGSSAT	DEG_SCF_TRCP1_1	1698:1704	Mutation altering degron motif	0.6932
p.D1698N	DO52402	UCEC	ICGC	DSGSSAT	DEG_SCF_TRCP1_1	1698:1704	Mutation altering degron motif	0.6932
p.L22I	TCGA-BR-4256	STAD	TCGA	SGCSGLVPSV	DEG_COP1_1	17:26	Mutation altering degron motif	0.6063
p.L22I	DO38743	STAD	ICGC	SGCSGLVPSV	DEG_COP1_1	17:26	Mutation altering degron motif	0.6063
p.A992T	TCGA-BR-4362	STAD	TCGA	PTPDKT	DEG_SCF_FBW7_1	1000:1005	Mutation rewiring degron network	0.1111
p.A992T	DO38336	STAD	ICGC	PTPDKT	DEG_SCF_FBW7_1	1000:1005	Mutation rewiring degron network	0.1111
p.P1707L	TCGA-D9-A6EC	SKCM	TCGA	DSGSSAT	DEG_SCF_TRCP1_1	1698:1704	Mutation rewiring degron network	0.25
p.P1707L	DO222955	BTCA	ICGC	DSGSSAT	DEG_SCF_TRCP1_1	1698:1704	Mutation rewiring degron network	0.25
p.P1707L	DO50291	SKCM	ICGC	DSGSSAT	DEG_SCF_TRCP1_1	1698:1704	Mutation rewiring degron network	0.25
p.S1077A	TCGA-E6-A1M0	UCEC	TCGA	CKENP	DEG_APCC_KENBOX_2	1065:1069	Mutation blocking phosphorylation signal	0.5556
p.S1077A	DO43682	UCEC	ICGC	CKENP	DEG_APCC_KENBOX_2	1065:1069	Mutation blocking phosphorylation signal	0.5556
p.P1685S	TCGA-EB-A41A	SKCM	TCGA	VSETPPLS	DEG_SCF_FBW7_1	1681:1688	Mutation altering degron motif	0.6752
p.P1685S	DO37429	SKCM	ICGC	VSETPPLS	DEG_SCF_FBW7_1	1681:1688	Mutation altering degron motif	0.6752
p.P1707S	TCGA-EE-A182	SKCM	TCGA	DSGSSAT	DEG_SCF_TRCP1_1	1698:1704	Mutation rewiring degron network	0.25
p.P1707S	DO37814	SKCM	ICGC	DSGSSAT	DEG_SCF_TRCP1_1	1698:1704	Mutation rewiring degron network	0.25
p.T1005M	TCGA-EO-A22R	UCEC	TCGA	PTPDKT	DEG_SCF_FBW7_1	1000:1005	Mutation altering degron motif	0.8534
p.T1005M	DO42713	UCEC	ICGC	PTPDKT	DEG_SCF_FBW7_1	1000:1005	Mutation altering degron motif	0.8534
p.L1687F	TCGA-FS-A1ZK	SKCM	TCGA	VSETPPLS	DEG_SCF_FBW7_1	1681:1688	Mutation altering degron motif	0.587
p.L1687F	DO37474	SKCM	ICGC	VSETPPLS	DEG_SCF_FBW7_1	1681:1688	Mutation altering degron motif	0.587
p.R1711C	TCGA-G4-6293	COAD	TCGA	DSGSSAT	DEG_SCF_TRCP1_1	1698:1704	Mutation rewiring degron network	0.1389
p.R1711C	DO10405	COAD	ICGC	DSGSSAT	DEG_SCF_TRCP1_1	1698:1704	Mutation rewiring degron network	0.1389
p.P1707Q	TCGA-G4-6628	COAD	TCGA	DSGSSAT	DEG_SCF_TRCP1_1	1698:1704	Mutation rewiring degron network	0.25
p.P1707Q	DO10132	COAD	ICGC	DSGSSAT	DEG_SCF_TRCP1_1	1698:1704	Mutation rewiring degron network	0.25
p.D1693N	TCGA-HU-A4GN	STAD	TCGA	VSETPPLS	DEG_SCF_FBW7_1	1681:1688	Mutation rewiring degron network	0.1944
p.D1693N	TCGA-HU-A4GN	STAD	TCGA	DSGSSAT	DEG_SCF_TRCP1_1	1698:1704	Mutation rewiring degron network	0.1944
p.D1693N	DO47833	STAD	ICGC	VSETPPLS	DEG_SCF_FBW7_1	1681:1688	Mutation rewiring degron network	0.1944
p.D1693N	DO47833	STAD	ICGC	DSGSSAT	DEG_SCF_TRCP1_1	1698:1704	Mutation rewiring degron network	0.1944
p.A1015T	TCGA-IB-7651	PAAD	TCGA	PTPDKT	DEG_SCF_FBW7_1	1000:1005	Mutation rewiring degron network	0.0556
p.A1015T	DO46657	PAAD	ICGC	PTPDKT	DEG_SCF_FBW7_1	1000:1005	Mutation rewiring degron network	0.0556
p.S20N	TCGA-RW-A685	PCPG	TCGA	SGCSGLVPSV	DEG_COP1_1	17:26	Mutation altering degron motif	0.7069
p.P1686S	TCGA-W3-A824	SKCM	TCGA	VSETPPLS	DEG_SCF_FBW7_1	1681:1688	Mutation altering degron motif	0.5641
p.P1686S	DO51271	SKCM	ICGC	VSETPPLS	DEG_SCF_FBW7_1	1681:1688	Mutation altering degron motif	0.5641
p.D251V	DO224704	BRCA	ICGC	NVSSGE	DEG_Kelch_Keap1_1	253:258	Mutation rewiring degron network	0.2778
p.L1466V	DO233123	GACA	ICGC	QKEND	DEG_APCC_KENBOX_2	1474:1478	Mutation rewiring degron network	0.1111
p.R1251W	DO228920	LICA	ICGC	PPRY	ITCH	1239:1242	Mutation rewiring degron network	0.0833
p.A264D	DO228948	LICA	ICGC	NVSSGE	DEG_Kelch_Keap1_1	253:258	Mutation rewiring degron network	0.1667
p.Q1249K	DO229015	LICA	ICGC	PPRY	ITCH	1239:1242	Mutation rewiring degron network	0.1389
p.D1691E	DO229028	LICA	ICGC	VSETPPLS	DEG_SCF_FBW7_1	1681:1688	Mutation rewiring degron network	0.25
p.D1691E	DO229028	LICA	ICGC	DSGSSAT	DEG_SCF_TRCP1_1	1698:1704	Mutation rewiring degron network	0.1389
p.T1692K	DO229022	LICA	ICGC	VSETPPLS	DEG_SCF_FBW7_1	1681:1688	Mutation rewiring degron network	0.2222
p.T1692K	DO229022	LICA	ICGC	DSGSSAT	DEG_SCF_TRCP1_1	1698:1704	Mutation rewiring degron network	0.1667
p.A1464E	DO229026	LICA	ICGC	QKEND	DEG_APCC_KENBOX_2	1474:1478	Mutation rewiring degron network	0.0556
p.P1707T	DO229045	LICA	ICGC	DSGSSAT	DEG_SCF_TRCP1_1	1698:1704	Mutation rewiring degron network	0.25
p.N1232S	DO231848	LINC	ICGC	PPRY	ITCH	1239:1242	Mutation rewiring degron network	0.1389
p.S1077L	DO50727	ORCA	ICGC	CKENP	DEG_APCC_KENBOX_2	1065:1069	Mutation blocking phosphorylation signal	0.5556
p.C767Y	DO232761	PBCA	ICGC	LAPLFNEKATLLL	DEG_ODPH_VHL_1	777:789	Mutation rewiring degron network	0.0556
p.S1710P	DO219881	SKCA	ICGC	DSGSSAT	DEG_SCF_TRCP1_1	1698:1704	Mutation rewiring degron network	0.1667
p.P1012L	DO229446	SKCA	ICGC	PTPDKT	DEG_SCF_FBW7_1	1000:1005	Mutation rewiring degron network	0.1389
p.S1710F	DO229462	SKCA	ICGC	DSGSSAT	DEG_SCF_TRCP1_1	1698:1704	Mutation rewiring degron network	0.1667
p.R1471I	DO229259	THCA	ICGC	QKEND	DEG_APCC_KENBOX_2	1474:1478	Mutation rewiring degron network	0.25
p.P1069T	SIDM02021	Esophageal Carcinoma	GDSC	CKENP	DEG_APCC_KENBOX_2	1065:1069	Mutation altering degron motif	0.5919
p.P1069T	SIDM00481	Ovarian Carcinoma	GDSC	CKENP	DEG_APCC_KENBOX_2	1065:1069	Mutation altering degron motif	0.5919
p.P1069T	ACH-000116	Ovarian Cancer	CCLE	CKENP	DEG_APCC_KENBOX_2	1065:1069	Mutation altering degron motif	0.5919
p.P1069T	OAW-28	ovary	COSMIC	CKENP	DEG_APCC_KENBOX_2	1065:1069	Mutation altering degron motif	0.5919
p.C249S	SIDM00845	Burkitt's Lymphoma	GDSC	NVSSGE	DEG_Kelch_Keap1_1	253:258	Mutation rewiring degron network	0.2222
p.C249S	SIDM00461	Acute Myeloid Leukemia	GDSC	NVSSGE	DEG_Kelch_Keap1_1	253:258	Mutation rewiring degron network	0.2222
p.L1059I	SIDM00789	Colorectal Carcinoma	GDSC	CKENP	DEG_APCC_KENBOX_2	1065:1069	Mutation rewiring degron network	0.1667
p.L1059I	ACH-000997	Colon/Colorectal Cancer	CCLE	CKENP	DEG_APCC_KENBOX_2	1065:1069	Mutation rewiring degron network	0.1667
p.L1059I	HCT-15	large intestine	COSMIC	CKENP	DEG_APCC_KENBOX_2	1065:1069	Mutation rewiring degron network	0.1667
p.F773L	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LAPLFNEKATLLL	DEG_ODPH_VHL_1	777:789	Mutation rewiring degron network	0.2222
p.F773L	ACH-002256	Leukemia	CCLE	LAPLFNEKATLLL	DEG_ODPH_VHL_1	777:789	Mutation rewiring degron network	0.2222
p.F773L	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LAPLFNEKATLLL	DEG_ODPH_VHL_1	777:789	Mutation rewiring degron network	0.2222
p.V1713I	SIDM00447	B-Lymphoblastic Leukemia	GDSC	DSGSSAT	DEG_SCF_TRCP1_1	1698:1704	Mutation rewiring degron network	0.0833
p.V1713I	ACH-000960	Leukemia	CCLE	DSGSSAT	DEG_SCF_TRCP1_1	1698:1704	Mutation rewiring degron network	0.0833
p.V1713I	REH	haematopoietic and lymphoid tissue	COSMIC	DSGSSAT	DEG_SCF_TRCP1_1	1698:1704	Mutation rewiring degron network	0.0833
p.A994T	SIDM00596	Endometrial Carcinoma	GDSC	PTPDKT	DEG_SCF_FBW7_1	1000:1005	Mutation rewiring degron network	0.1667
p.A994T	ACH-001517	Endometrial/Uterine Cancer	CCLE	PTPDKT	DEG_SCF_FBW7_1	1000:1005	Mutation rewiring degron network	0.1667
p.A994T	HEC-1	endometrium	COSMIC	PTPDKT	DEG_SCF_FBW7_1	1000:1005	Mutation rewiring degron network	0.1667
p.V12L	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	SGCSGLVPSV	DEG_COP1_1	17:26	Mutation rewiring degron network	0.1944
p.V12L	SIDM01525	Acute Myeloid Leukemia	GDSC	SGCSGLVPSV	DEG_COP1_1	17:26	Mutation rewiring degron network	0.1944
p.L1484I	SIDM00948	Burkitt's Lymphoma	GDSC	QKEND	DEG_APCC_KENBOX_2	1474:1478	Mutation rewiring degron network	0.1667
p.L1484I	DG-75	haematopoietic and lymphoid tissue	COSMIC	QKEND	DEG_APCC_KENBOX_2	1474:1478	Mutation rewiring degron network	0.1667
p.S791Y	SIDM00438	B-Lymphoblastic Leukemia	GDSC	LAPLFNEKATLLL	DEG_ODPH_VHL_1	777:789	Mutation blocking phosphorylation signal	0.7222
p.S791Y	ACH-002275	Leukemia	CCLE	LAPLFNEKATLLL	DEG_ODPH_VHL_1	777:789	Mutation blocking phosphorylation signal	0.7222
p.S791Y	MN-60	haematopoietic and lymphoid tissue	COSMIC	LAPLFNEKATLLL	DEG_ODPH_VHL_1	777:789	Mutation blocking phosphorylation signal	0.7222
p.M1465V	SIDM00479	Esophageal Carcinoma	GDSC	QKEND	DEG_APCC_KENBOX_2	1474:1478	Mutation rewiring degron network	0.0833
p.M1465V	ACH-000679	Esophageal Cancer	CCLE	QKEND	DEG_APCC_KENBOX_2	1474:1478	Mutation rewiring degron network	0.0833
p.M1465V	OE19	oesophagus	COSMIC	QKEND	DEG_APCC_KENBOX_2	1474:1478	Mutation rewiring degron network	0.0833
p.E243K	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	NVSSGE	DEG_Kelch_Keap1_1	253:258	Mutation rewiring degron network	0.0556
p.E243K	ACH-000888	Lung Cancer	CCLE	NVSSGE	DEG_Kelch_Keap1_1	253:258	Mutation rewiring degron network	0.0556
p.E243K	NCI-H1793	lung	COSMIC	NVSSGE	DEG_Kelch_Keap1_1	253:258	Mutation rewiring degron network	0.0556
p.F773S	ACH-001610	Brain Cancer	CCLE	LAPLFNEKATLLL	DEG_ODPH_VHL_1	777:789	Mutation rewiring degron network	0.2222
p.V1483I	REH	haematopoietic and lymphoid tissue	COSMIC	QKEND	DEG_APCC_KENBOX_2	1474:1478	Mutation rewiring degron network	0.1944
p.T799S	SW837	large intestine	COSMIC	LAPLFNEKATLLL	DEG_ODPH_VHL_1	777:789	Mutation rewiring degron network	0.0556
p.A1076V	HCC-15	lung	COSMIC	CKENP	DEG_APCC_KENBOX_2	1065:1069	Mutation blocking phosphorylation signal	0.5833
p.L993V	KU-19-19	urinary tract	COSMIC	PTPDKT	DEG_SCF_FBW7_1	1000:1005	Mutation rewiring degron network	0.1389
p.K1690N	SNU-81	large intestine	COSMIC	VSETPPLS	DEG_SCF_FBW7_1	1681:1688	Mutation rewiring degron network	0.2778
p.K1690N	SNU-81	large intestine	COSMIC	DSGSSAT	DEG_SCF_TRCP1_1	1698:1704	Mutation rewiring degron network	0.1111
p.Q1685H	MDA-MB-436	breast	COSMIC	VSETPPLS	DEG_SCF_FBW7_1	1681:1688	Mutation altering degron motif	0.7582
p.M1235V	OE19	oesophagus	COSMIC	PPRY	ITCH	1239:1242	Mutation rewiring degron network	0.2222
p.P1696L	RVH-421	skin	COSMIC	VSETPPLS	DEG_SCF_FBW7_1	1681:1688	Mutation rewiring degron network	0.1111
p.P1696L	RVH-421	skin	COSMIC	DSGSSAT	DEG_SCF_TRCP1_1	1698:1704	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDK5RAP2

UniProt ID: Q96SN8

Entrez ID: 55755

Protein name: CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDK5RAP2 in