DegronMD

Uniprot ID: Q96SN8

Source protein: CDK5 regulatory subunit-associated protein 2

Source gene: CDK5RAP2

Class: DEG_COP1_1

Location: 17:26

E3 ligase: COP1

DEGRON score: 0.9794

ASA_SCORE: 61.78

COIL: 0.9125

CONS_SCORE: 0.3879

DSS_SCORE: 0.4417

HELIX: 0.0348

FCONS_SCORE: 0.957

RIG_SCORE: 0.711

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E8G	TCGA-12-0775	GBM	TCGA	SGCSGLVPSV	DEG_COP1_1	0.0833
p.E8G	DO14133	GBM	ICGC	SGCSGLVPSV	DEG_COP1_1	0.0833
p.L22I	TCGA-BR-4256	STAD	TCGA	SGCSGLVPSV	DEG_COP1_1	0.6063
p.L22I	DO38743	STAD	ICGC	SGCSGLVPSV	DEG_COP1_1	0.6063
p.S20N	TCGA-RW-A685	PCPG	TCGA	SGCSGLVPSV	DEG_COP1_1	0.7069
p.V12L	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	SGCSGLVPSV	DEG_COP1_1	0.1944
p.V12L	SIDM01525	Acute Myeloid Leukemia	GDSC	SGCSGLVPSV	DEG_COP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96SN8	CDK5 regulatory subunit-associated protein 2	DEG_COP1_1	17:26	SGCSGLVPSV	COP1	0.9794	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons