DegronMD

Uniprot ID: Q96SN8

Source protein: CDK5 regulatory subunit-associated protein 2

Source gene: CDK5RAP2

Class: DEG_Kelch_Keap1_1

Location: 253:258

E3 ligase: KEAP1

DEGRON score: 0.9254

ASA_SCORE: 80.3667

COIL: 0.3182

CONS_SCORE: 0.4637

DSS_SCORE: 0.4144

HELIX: 0.6767

FCONS_SCORE: 1.31

RIG_SCORE: 0.667

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D251V	DO224704	BRCA	ICGC	NVSSGE	DEG_Kelch_Keap1_1	0.2778
p.A264D	DO228948	LICA	ICGC	NVSSGE	DEG_Kelch_Keap1_1	0.1667
p.C249S	SIDM00845	Burkitt's Lymphoma	GDSC	NVSSGE	DEG_Kelch_Keap1_1	0.2222
p.C249S	SIDM00461	Acute Myeloid Leukemia	GDSC	NVSSGE	DEG_Kelch_Keap1_1	0.2222
p.E243K	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	NVSSGE	DEG_Kelch_Keap1_1	0.0556
p.E243K	ACH-000888	Lung Cancer	CCLE	NVSSGE	DEG_Kelch_Keap1_1	0.0556
p.E243K	NCI-H1793	lung	COSMIC	NVSSGE	DEG_Kelch_Keap1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96SN8	CDK5 regulatory subunit-associated protein 2	DEG_Kelch_Keap1_1	253:258	NVSSGE	KEAP1	0.9254	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons