DegronMD

Uniprot ID: Q96SN8

Source protein: CDK5 regulatory subunit-associated protein 2

Source gene: CDK5RAP2

Class: DEG_ODPH_VHL_1

Location: 777:789

E3 ligase: VHL

DEGRON score: 0.5775

ASA_SCORE: 92.8538

COIL: 0.174

CONS_SCORE: 0.4222

DSS_SCORE: 0.0425

HELIX: 0.8202

FCONS_SCORE: 1.2382

RIG_SCORE: 0.875

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E790D	TCGA-AX-A05Z	UCEC	TCGA	LAPLFNEKATLLL	DEG_ODPH_VHL_1	0.3056
p.E790D	DO40884	UCEC	ICGC	LAPLFNEKATLLL	DEG_ODPH_VHL_1	0.3056
p.C767Y	DO232761	PBCA	ICGC	LAPLFNEKATLLL	DEG_ODPH_VHL_1	0.0556
p.F773L	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LAPLFNEKATLLL	DEG_ODPH_VHL_1	0.2222
p.F773L	ACH-002256	Leukemia	CCLE	LAPLFNEKATLLL	DEG_ODPH_VHL_1	0.2222
p.F773L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LAPLFNEKATLLL	DEG_ODPH_VHL_1	0.2222
p.S791Y	SIDM00438	B-Lymphoblastic Leukemia	GDSC	LAPLFNEKATLLL	DEG_ODPH_VHL_1	0.7222
p.S791Y	ACH-002275	Leukemia	CCLE	LAPLFNEKATLLL	DEG_ODPH_VHL_1	0.7222
p.S791Y	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	LAPLFNEKATLLL	DEG_ODPH_VHL_1	0.7222
p.F773S	ACH-001610	Brain Cancer	CCLE	LAPLFNEKATLLL	DEG_ODPH_VHL_1	0.2222
p.T799S	SW837	large_intestine	COSMIC	LAPLFNEKATLLL	DEG_ODPH_VHL_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96SN8	CDK5 regulatory subunit-associated protein 2	DEG_ODPH_VHL_1	777:789	LAPLFNEKATLLL	VHL	0.5775	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons