DegronMD

Uniprot ID: Q96SN8

Source protein: CDK5 regulatory subunit-associated protein 2

Source gene: CDK5RAP2

Class: DEG_SCF_TRCP1_1

Location: 1698:1704

E3 ligase: BTRC

DEGRON score: 0.9824

ASA_SCORE: 81.4571

COIL: 0.9331

CONS_SCORE: 0.3245

DSS_SCORE: 0.414

HELIX: 0.0469

FCONS_SCORE: 0.9209

RIG_SCORE: 0.6139

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1698N	TCGA-B5-A3FA	UCEC	TCGA	DSGSSAT	DEG_SCF_TRCP1_1	0.6932
p.D1698N	DO52402	UCEC	ICGC	DSGSSAT	DEG_SCF_TRCP1_1	0.6932
p.P1707L	TCGA-D9-A6EC	SKCM	TCGA	DSGSSAT	DEG_SCF_TRCP1_1	0.25
p.P1707L	DO222955	BTCA	ICGC	DSGSSAT	DEG_SCF_TRCP1_1	0.25
p.P1707L	DO50291	SKCM	ICGC	DSGSSAT	DEG_SCF_TRCP1_1	0.25
p.P1707S	TCGA-EE-A182	SKCM	TCGA	DSGSSAT	DEG_SCF_TRCP1_1	0.25
p.P1707S	DO37814	SKCM	ICGC	DSGSSAT	DEG_SCF_TRCP1_1	0.25
p.R1711C	TCGA-G4-6293	COAD	TCGA	DSGSSAT	DEG_SCF_TRCP1_1	0.1389
p.R1711C	DO10405	COAD	ICGC	DSGSSAT	DEG_SCF_TRCP1_1	0.1389
p.P1707Q	TCGA-G4-6628	COAD	TCGA	DSGSSAT	DEG_SCF_TRCP1_1	0.25
p.P1707Q	DO10132	COAD	ICGC	DSGSSAT	DEG_SCF_TRCP1_1	0.25
p.D1693N	TCGA-HU-A4GN	STAD	TCGA	DSGSSAT	DEG_SCF_TRCP1_1	0.1944
p.D1693N	DO47833	STAD	ICGC	DSGSSAT	DEG_SCF_TRCP1_1	0.1944
p.D1691E	DO229028	LICA	ICGC	DSGSSAT	DEG_SCF_TRCP1_1	0.1389
p.T1692K	DO229022	LICA	ICGC	DSGSSAT	DEG_SCF_TRCP1_1	0.1667
p.P1707T	DO229045	LICA	ICGC	DSGSSAT	DEG_SCF_TRCP1_1	0.25
p.S1710P	DO219881	SKCA	ICGC	DSGSSAT	DEG_SCF_TRCP1_1	0.1667
p.S1710F	DO229462	SKCA	ICGC	DSGSSAT	DEG_SCF_TRCP1_1	0.1667
p.V1713I	SIDM00447	B-Lymphoblastic Leukemia	GDSC	DSGSSAT	DEG_SCF_TRCP1_1	0.0833
p.V1713I	ACH-000960	Leukemia	CCLE	DSGSSAT	DEG_SCF_TRCP1_1	0.0833
p.V1713I	REH	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSSAT	DEG_SCF_TRCP1_1	0.0833
p.K1690N	SNU-81	large_intestine	COSMIC	DSGSSAT	DEG_SCF_TRCP1_1	0.1111
p.P1696L	RVH-421	skin	COSMIC	DSGSSAT	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96SN8	CDK5 regulatory subunit-associated protein 2	DEG_SCF_TRCP1_1	1698:1704	DSGSSAT	BTRC	0.9824	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons