DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VSETPPLS
Uniprot ID:
Q96SN8
Source protein:
CDK5 regulatory subunit-associated protein 2
Source gene:
CDK5RAP2
Class:
DEG_SCF_FBW7_1
Location:
1681:1688
E3 ligase:
FBXW7
DEGRON score:
0.933
ASA_SCORE:
93.6875
COIL:
0.9343
CONS_SCORE:
0.349
DSS_SCORE:
0.6371
HELIX:
0.0375
FCONS_SCORE:
0.9268
RIG_SCORE:
0.6224
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P1685S
TCGA-EB-A41A
SKCM
TCGA
VSETPPLS
DEG_SCF_FBW7_1
0.6752
p.P1685S
DO37429
SKCM
ICGC
VSETPPLS
DEG_SCF_FBW7_1
0.6752
p.L1687F
TCGA-FS-A1ZK
SKCM
TCGA
VSETPPLS
DEG_SCF_FBW7_1
0.587
p.L1687F
DO37474
SKCM
ICGC
VSETPPLS
DEG_SCF_FBW7_1
0.587
p.D1693N
TCGA-HU-A4GN
STAD
TCGA
VSETPPLS
DEG_SCF_FBW7_1
0.1944
p.D1693N
DO47833
STAD
ICGC
VSETPPLS
DEG_SCF_FBW7_1
0.1944
p.P1686S
TCGA-W3-A824
SKCM
TCGA
VSETPPLS
DEG_SCF_FBW7_1
0.5641
p.P1686S
DO51271
SKCM
ICGC
VSETPPLS
DEG_SCF_FBW7_1
0.5641
p.D1691E
DO229028
LICA
ICGC
VSETPPLS
DEG_SCF_FBW7_1
0.25
p.T1692K
DO229022
LICA
ICGC
VSETPPLS
DEG_SCF_FBW7_1
0.2222
p.K1690N
SNU-81
large_intestine
COSMIC
VSETPPLS
DEG_SCF_FBW7_1
0.2778
p.Q1685H
MDA-MB-436
breast
COSMIC
VSETPPLS
DEG_SCF_FBW7_1
0.7582
p.P1696L
RVH-421
skin
COSMIC
VSETPPLS
DEG_SCF_FBW7_1
0.1111
Drug responses associated with CDK5RAP2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VSETPPLS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96SN8
CDK5 regulatory subunit-associated protein 2
DEG_SCF_FBW7_1
1681:1688
VSETPPLS
FBXW7
0.933
More...