DegronMD

Uniprot ID: Q96SN8

Source protein: CDK5 regulatory subunit-associated protein 2

Source gene: CDK5RAP2

Class: DEG_SCF_FBW7_1

Location: 1681:1688

E3 ligase: FBXW7

DEGRON score: 0.933

ASA_SCORE: 93.6875

COIL: 0.9343

CONS_SCORE: 0.349

DSS_SCORE: 0.6371

HELIX: 0.0375

FCONS_SCORE: 0.9268

RIG_SCORE: 0.6224

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1685H	MDA-MB-436	breast	COSMIC	VSETPPLS	DEG_SCF_FBW7_1	0.7582
p.P1685S	TCGA-EB-A41A	SKCM	TCGA	VSETPPLS	DEG_SCF_FBW7_1	0.6752
p.P1685S	DO37429	SKCM	ICGC	VSETPPLS	DEG_SCF_FBW7_1	0.6752
p.L1687F	TCGA-FS-A1ZK	SKCM	TCGA	VSETPPLS	DEG_SCF_FBW7_1	0.587
p.L1687F	DO37474	SKCM	ICGC	VSETPPLS	DEG_SCF_FBW7_1	0.587
p.P1686S	TCGA-W3-A824	SKCM	TCGA	VSETPPLS	DEG_SCF_FBW7_1	0.5641
p.P1686S	DO51271	SKCM	ICGC	VSETPPLS	DEG_SCF_FBW7_1	0.5641
p.K1690N	SNU-81	large_intestine	COSMIC	VSETPPLS	DEG_SCF_FBW7_1	0.2778
p.D1691E	DO229028	LICA	ICGC	VSETPPLS	DEG_SCF_FBW7_1	0.25
p.T1692K	DO229022	LICA	ICGC	VSETPPLS	DEG_SCF_FBW7_1	0.2222
p.D1693N	TCGA-HU-A4GN	STAD	TCGA	VSETPPLS	DEG_SCF_FBW7_1	0.1944
p.D1693N	DO47833	STAD	ICGC	VSETPPLS	DEG_SCF_FBW7_1	0.1944
p.P1696L	RVH-421	skin	COSMIC	VSETPPLS	DEG_SCF_FBW7_1	0.1111

Showing 1 to 13 of 13 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96SN8	CDK5 regulatory subunit-associated protein 2	DEG_SCF_FBW7_1	1681:1688	VSETPPLS	FBXW7	0.933	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons