DegronMD

Uniprot ID: Q96SN8

Source protein: CDK5 regulatory subunit-associated protein 2

Source gene: CDK5RAP2

Class: DEG_SCF_FBW7_1

Location: 1000:1005

E3 ligase: FBXW7

DEGRON score: 0.9583

ASA_SCORE: 98.3667

COIL: 0.775

CONS_SCORE: 0.3186

DSS_SCORE: 0.5679

HELIX: 0.2035

FCONS_SCORE: 0.8304

RIG_SCORE: 0.7152

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1012H	TCGA-AP-A1DP	UCEC	TCGA	PTPDKT	DEG_SCF_FBW7_1	0.1389
p.P1012H	DO42336	UCEC	ICGC	PTPDKT	DEG_SCF_FBW7_1	0.1389
p.A992T	TCGA-BR-4362	STAD	TCGA	PTPDKT	DEG_SCF_FBW7_1	0.1111
p.A992T	DO38336	STAD	ICGC	PTPDKT	DEG_SCF_FBW7_1	0.1111
p.T1005M	TCGA-EO-A22R	UCEC	TCGA	PTPDKT	DEG_SCF_FBW7_1	0.8534
p.T1005M	DO42713	UCEC	ICGC	PTPDKT	DEG_SCF_FBW7_1	0.8534
p.A1015T	TCGA-IB-7651	PAAD	TCGA	PTPDKT	DEG_SCF_FBW7_1	0.0556
p.A1015T	DO46657	PAAD	ICGC	PTPDKT	DEG_SCF_FBW7_1	0.0556
p.P1012L	DO229446	SKCA	ICGC	PTPDKT	DEG_SCF_FBW7_1	0.1389
p.A994T	SIDM00596	Endometrial Carcinoma	GDSC	PTPDKT	DEG_SCF_FBW7_1	0.1667
p.A994T	ACH-001517	Endometrial/Uterine Cancer	CCLE	PTPDKT	DEG_SCF_FBW7_1	0.1667
p.A994T	HEC-1	endometrium	COSMIC	PTPDKT	DEG_SCF_FBW7_1	0.1667
p.L993V	KU-19-19	urinary_tract	COSMIC	PTPDKT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96SN8	CDK5 regulatory subunit-associated protein 2	DEG_SCF_FBW7_1	1000:1005	PTPDKT	FBXW7	0.9583	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons