DegronMD

Uniprot ID: Q96SN8

Source protein: CDK5 regulatory subunit-associated protein 2

Source gene: CDK5RAP2

Class: DEG_APCC_KENBOX_2

Location: 1474:1478

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7395

ASA_SCORE: 108.16

COIL: 0.067

CONS_SCORE: 0.5273

DSS_SCORE: 0.5584

HELIX: 0.9362

FCONS_SCORE: 1.4367

RIG_SCORE: 0.6975

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1469V	TCGA-24-2293	OV	TCGA	QKEND	DEG_APCC_KENBOX_2	0.1944
p.G1469V	DO28005	OV	ICGC	QKEND	DEG_APCC_KENBOX_2	0.1944
p.L1466V	DO233123	GACA	ICGC	QKEND	DEG_APCC_KENBOX_2	0.1111
p.A1464E	DO229026	LICA	ICGC	QKEND	DEG_APCC_KENBOX_2	0.0556
p.R1471I	DO229259	THCA	ICGC	QKEND	DEG_APCC_KENBOX_2	0.25
p.L1484I	SIDM00948	Burkitt's Lymphoma	GDSC	QKEND	DEG_APCC_KENBOX_2	0.1667
p.L1484I	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	QKEND	DEG_APCC_KENBOX_2	0.1667
p.M1465V	SIDM00479	Esophageal Carcinoma	GDSC	QKEND	DEG_APCC_KENBOX_2	0.0833
p.M1465V	ACH-000679	Esophageal Cancer	CCLE	QKEND	DEG_APCC_KENBOX_2	0.0833
p.M1465V	OE19	oesophagus	COSMIC	QKEND	DEG_APCC_KENBOX_2	0.0833
p.V1483I	REH	haematopoietic_and_lymphoid_tissue	COSMIC	QKEND	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N1H7	Protein SIX6OS1	DEG_APCC_KENBOX_2	318:322	QKEND	APC,CDC20,FZR1	0.8637	More...
Q96SN8	CDK5 regulatory subunit-associated protein 2	DEG_APCC_KENBOX_2	1474:1478	QKEND	APC,CDC20,FZR1	0.7395	More...
Q8N7Z5	Ankyrin repeat domain-containing protein 31	DEG_APCC_KENBOX_2	1560:1564	QKEND	APC,CDC20,FZR1	0.6997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons