DegronMD

Uniprot ID: Q8N1H7

Source protein: Protein SIX6OS1

Source gene: SIX6OS1

Class: DEG_APCC_KENBOX_2

Location: 318:322

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8637

ASA_SCORE: 112.46

COIL: 0.516

CONS_SCORE: 0.6175

DSS_SCORE: 0.4344

HELIX: 0.4686

FCONS_SCORE: 1.1859

RIG_SCORE: 0.7486

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D322N	TCGA-BF-A5EQ	SKCM	TCGA	QKEND	DEG_APCC_KENBOX_2	0.5821
p.D322N	TCGA-EE-A3AC	SKCM	TCGA	QKEND	DEG_APCC_KENBOX_2	0.5821
p.D322N	DO37631	SKCM	ICGC	QKEND	DEG_APCC_KENBOX_2	0.5821
p.D322N	DO219452	SKCM	ICGC	QKEND	DEG_APCC_KENBOX_2	0.5821
p.T323A	TCGA-FI-A2D6	UCEC	TCGA	QKEND	DEG_APCC_KENBOX_2	0.3056
p.T323A	DO43867	UCEC	ICGC	QKEND	DEG_APCC_KENBOX_2	0.3056
p.N327D	DO231649	LINC	ICGC	QKEND	DEG_APCC_KENBOX_2	0.1944
p.K319Q	SIDM01300	Colorectal Carcinoma	GDSC	QKEND	DEG_APCC_KENBOX_2	0.6944
p.D315E	SIDM00437	Acute Myeloid Leukemia	GDSC	QKEND	DEG_APCC_KENBOX_2	0.25
p.D315E	SIDM00338	Acute Myeloid Leukemia	GDSC	QKEND	DEG_APCC_KENBOX_2	0.25
p.D315E	SIDM00216	Colorectal Carcinoma	GDSC	QKEND	DEG_APCC_KENBOX_2	0.25
p.D315E	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	QKEND	DEG_APCC_KENBOX_2	0.25
p.D315E	SIDM00619	Thyroid Gland Carcinoma	GDSC	QKEND	DEG_APCC_KENBOX_2	0.25
p.D315E	SIDM01217	Other Blood Cancers	GDSC	QKEND	DEG_APCC_KENBOX_2	0.25
p.D315E	SIDM01372	Pancreatic Carcinoma	GDSC	QKEND	DEG_APCC_KENBOX_2	0.25
p.D315E	SIDM01588	Endometrial Carcinoma	GDSC	QKEND	DEG_APCC_KENBOX_2	0.25
p.T323I	SIDM01263	T-Lymphoblastic Leukemia	GDSC	QKEND	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N1H7	Protein SIX6OS1	DEG_APCC_KENBOX_2	318:322	QKEND	APC,CDC20,FZR1	0.8637	More...
Q96SN8	CDK5 regulatory subunit-associated protein 2	DEG_APCC_KENBOX_2	1474:1478	QKEND	APC,CDC20,FZR1	0.7395	More...
Q8N7Z5	Ankyrin repeat domain-containing protein 31	DEG_APCC_KENBOX_2	1560:1564	QKEND	APC,CDC20,FZR1	0.6997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons