DegronMD - Q8N7Z5(ANKRD31)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G60C	TCGA-AP-A0LM	UCEC	TCGA	FSLHPD	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1389
p.G60C	DO43306	UCEC	ICGC	FSLHPD	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1389
p.E150K	TCGA-AP-A1DV	UCEC	TCGA	VLPHIE	LIG_APCC_ABBA_1	143:148	Mutation rewiring degron network	0.2778
p.E150K	DO43186	UCEC	ICGC	VLPHIE	LIG_APCC_ABBA_1	143:148	Mutation rewiring degron network	0.2778
p.N491K	TCGA-B5-A1MR	UCEC	TCGA	RRNIFGE	LIG_APCC_ABBAyCdc20_2	484:490	Mutation rewiring degron network	0.3056
p.N491K	DO41758	UCEC	ICGC	RRNIFGE	LIG_APCC_ABBAyCdc20_2	484:490	Mutation rewiring degron network	0.3056
p.D500N	TCGA-D1-A16J	UCEC	TCGA	RRNIFGE	LIG_APCC_ABBAyCdc20_2	484:490	Mutation rewiring degron network	0.0556
p.D500N	DO43033	UCEC	ICGC	RRNIFGE	LIG_APCC_ABBAyCdc20_2	484:490	Mutation rewiring degron network	0.0556
p.E134G	TCGA-EO-A22S	UCEC	TCGA	VLPHIE	LIG_APCC_ABBA_1	143:148	Mutation rewiring degron network	0.0833
p.E134G	DO41590	UCEC	ICGC	VLPHIE	LIG_APCC_ABBA_1	143:148	Mutation rewiring degron network	0.0833
p.E490D	TCGA-EO-A3AV	UCEC	TCGA	RRNIFGE	LIG_APCC_ABBAyCdc20_2	484:490	Mutation altering degron motif	0.5647
p.E490D	DO52412	UCEC	ICGC	RRNIFGE	LIG_APCC_ABBAyCdc20_2	484:490	Mutation altering degron motif	0.5647
p.P62H	TCGA-EO-A3KX	UCEC	TCGA	FSLHPD	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.0833
p.P62H	DO219774	UCEC	ICGC	FSLHPD	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.0833
p.A42T	TCGA-FI-A2D0	UCEC	TCGA	FSLHPD	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1667
p.A42T	DO43891	UCEC	ICGC	FSLHPD	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1667
p.E47Q	TCGA-Z6-A8JD	ESCA	TCGA	FSLHPD	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.3056
p.D156N	DO10172	COAD	ICGC	VLPHIE	LIG_APCC_ABBA_1	143:148	Mutation rewiring degron network	0.1111
p.S889Y	DO8730	COAD	ICGC	VKENS	DEG_APCC_KENBOX_2	894:898	Mutation rewiring degron network	0.1944
p.T1566R	DO229005	COCA	ICGC	QKEND	DEG_APCC_KENBOX_2	1560:1564	Mutation rewiring degron network	0.2778
p.T1566R	DO229480	LAML	ICGC	QKEND	DEG_APCC_KENBOX_2	1560:1564	Mutation rewiring degron network	0.2778
p.A138D	DO233762	GACA	ICGC	VLPHIE	LIG_APCC_ABBA_1	143:148	Mutation rewiring degron network	0.1944
p.H927N	DO229015	LICA	ICGC	FKENL	DEG_APCC_KENBOX_2	930:934	Mutation rewiring degron network	0.25
p.A497D	DO229024	LICA	ICGC	RRNIFGE	LIG_APCC_ABBAyCdc20_2	484:490	Mutation rewiring degron network	0.1389
p.K476E	DO44978	LIHC	ICGC	RRNIFGE	LIG_APCC_ABBAyCdc20_2	484:490	Mutation substituting flanking lysine	0.2222
p.P62R	DO220888	MELA	ICGC	FSLHPD	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.0833
p.G489E	DO220891	MELA	ICGC	RRNIFGE	LIG_APCC_ABBAyCdc20_2	484:490	Mutation altering degron motif	0.6087
p.D901N	DO222749	MELA	ICGC	VKENS	DEG_APCC_KENBOX_2	894:898	Mutation rewiring degron network	0.25
p.E887K	DO222875	MELA	ICGC	VKENS	DEG_APCC_KENBOX_2	894:898	Mutation rewiring degron network	0.1389
p.Q944H	DO46392	OV	ICGC	FKENL	DEG_APCC_KENBOX_2	930:934	Mutation rewiring degron network	0.0556
p.N884D	DO51478	PACA	ICGC	VKENS	DEG_APCC_KENBOX_2	894:898	Mutation rewiring degron network	0.0556
p.E939K	DO47542	SKCM	ICGC	FKENL	DEG_APCC_KENBOX_2	930:934	Mutation rewiring degron network	0.1944
p.D899G	DO231308	THCA	ICGC	VKENS	DEG_APCC_KENBOX_2	894:898	Mutation rewiring degron network	0.3056
p.G60S	SIDM02053	Colorectal Carcinoma	GDSC	FSLHPD	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1389
p.S49R	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	FSLHPD	LIG_APCC_ABBA_1	48:53	Mutation altering degron motif	0.6316
p.S49R	ACH-001233	Lung Cancer	CCLE	FSLHPD	LIG_APCC_ABBA_1	48:53	Mutation altering degron motif	0.6316
p.S49R	VMRC-LCD	lung	COSMIC	FSLHPD	LIG_APCC_ABBA_1	48:53	Mutation altering degron motif	0.6316
p.L151I	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VLPHIE	LIG_APCC_ABBA_1	143:148	Mutation rewiring degron network	0.25
p.L151I	ACH-000981	Leukemia	CCLE	VLPHIE	LIG_APCC_ABBA_1	143:148	Mutation rewiring degron network	0.25
p.L151I	DND-41	haematopoietic and lymphoid tissue	COSMIC	VLPHIE	LIG_APCC_ABBA_1	143:148	Mutation rewiring degron network	0.25
p.R484Q	SIDM00201	Ewing's Sarcoma	GDSC	RRNIFGE	LIG_APCC_ABBAyCdc20_2	484:490	Mutation altering degron motif	0.7329
p.R484Q	ACH-002119	Bone Cancer	CCLE	RRNIFGE	LIG_APCC_ABBAyCdc20_2	484:490	Mutation altering degron motif	0.7329
p.R484Q	EW-7	bone	COSMIC	RRNIFGE	LIG_APCC_ABBAyCdc20_2	484:490	Mutation altering degron motif	0.7329
p.S157Y	ACH-000820	Colon/Colorectal Cancer	CCLE	VLPHIE	LIG_APCC_ABBA_1	143:148	Mutation blocking phosphorylation signal	0.5278
p.D1573N	ACH-001550	Skin Cancer	CCLE	QKEND	DEG_APCC_KENBOX_2	1560:1564	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKRD31

UniProt ID: Q8N7Z5

Entrez ID: 256006

Protein name: Ankyrin repeat domain-containing protein 31

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ANKRD31 in