DegronMD

Uniprot ID: Q8N7Z5

Source protein: Ankyrin repeat domain-containing protein 31

Source gene: ANKRD31

Class: LIG_APCC_ABBA_1

Location: 48:53

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5581

ASA_SCORE: 51.1333

COIL: 0.618

CONS_SCORE: 0.5327

DSS_SCORE: 0.4619

HELIX: 0.1635

FCONS_SCORE: 1.0443

RIG_SCORE: 0.6964

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G60C	TCGA-AP-A0LM	UCEC	TCGA	FSLHPD	LIG_APCC_ABBA_1	0.1389
p.G60C	DO43306	UCEC	ICGC	FSLHPD	LIG_APCC_ABBA_1	0.1389
p.P62H	TCGA-EO-A3KX	UCEC	TCGA	FSLHPD	LIG_APCC_ABBA_1	0.0833
p.P62H	DO219774	UCEC	ICGC	FSLHPD	LIG_APCC_ABBA_1	0.0833
p.A42T	TCGA-FI-A2D0	UCEC	TCGA	FSLHPD	LIG_APCC_ABBA_1	0.1667
p.A42T	DO43891	UCEC	ICGC	FSLHPD	LIG_APCC_ABBA_1	0.1667
p.E47Q	TCGA-Z6-A8JD	ESCA	TCGA	FSLHPD	LIG_APCC_ABBA_1	0.3056
p.P62R	DO220888	MELA	ICGC	FSLHPD	LIG_APCC_ABBA_1	0.0833
p.G60S	SIDM02053	Colorectal Carcinoma	GDSC	FSLHPD	LIG_APCC_ABBA_1	0.1389
p.S49R	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	FSLHPD	LIG_APCC_ABBA_1	0.6316
p.S49R	ACH-001233	Lung Cancer	CCLE	FSLHPD	LIG_APCC_ABBA_1	0.6316
p.S49R	VMRC-LCD	lung	COSMIC	FSLHPD	LIG_APCC_ABBA_1	0.6316

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N7Z5	Ankyrin repeat domain-containing protein 31	LIG_APCC_ABBA_1	48:53	FSLHPD	APC,CDC20,FZR1	0.5581	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons