DegronMD

Uniprot ID: Q8N7Z5

Source protein: Ankyrin repeat domain-containing protein 31

Source gene: ANKRD31

Class: DEG_APCC_KENBOX_2

Location: 894:898

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9707

ASA_SCORE: 96.22

COIL: 0.6688

CONS_SCORE: 0.401

DSS_SCORE: 0.3689

HELIX: 0.2642

FCONS_SCORE: 1

RIG_SCORE: 0.7253

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S889Y	DO8730	COAD	ICGC	VKENS	DEG_APCC_KENBOX_2	0.1944
p.D901N	DO222749	MELA	ICGC	VKENS	DEG_APCC_KENBOX_2	0.25
p.E887K	DO222875	MELA	ICGC	VKENS	DEG_APCC_KENBOX_2	0.1389
p.N884D	DO51478	PACA	ICGC	VKENS	DEG_APCC_KENBOX_2	0.0556
p.D899G	DO231308	THCA	ICGC	VKENS	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95391	Pre-mRNA-splicing factor SLU7	DEG_APCC_KENBOX_2	106:110	VKENS	APC,CDC20,FZR1	0.6647	More...
Q15025	TNFAIP3-interacting protein 1	DEG_APCC_KENBOX_2	29:33	VKENS	APC,CDC20,FZR1	0.582	More...
P51815	Zinc finger protein 75D	DEG_APCC_KENBOX_2	26:30	VKENS	APC,CDC20,FZR1	0.6713	More...
Q8N7Z5	Ankyrin repeat domain-containing protein 31	DEG_APCC_KENBOX_2	894:898	VKENS	APC,CDC20,FZR1	0.9707	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons