DegronMD - O95391(SLU7)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R116H	TCGA-AP-A1DV	UCEC	TCGA	VKENS	DEG_APCC_KENBOX_2	106:110	Mutation rewiring degron network	0.1667
p.R116H	DO233088	GACA	ICGC	VKENS	DEG_APCC_KENBOX_2	106:110	Mutation rewiring degron network	0.1667
p.R116H	DO43186	UCEC	ICGC	VKENS	DEG_APCC_KENBOX_2	106:110	Mutation rewiring degron network	0.1667
p.R116C	TCGA-BG-A0M4	UCEC	TCGA	VKENS	DEG_APCC_KENBOX_2	106:110	Mutation rewiring degron network	0.1667
p.R116C	DO41686	UCEC	ICGC	VKENS	DEG_APCC_KENBOX_2	106:110	Mutation rewiring degron network	0.1667
p.L486F	TCGA-DA-A960	SKCM	TCGA	MELHQE	LIG_APCC_ABBA_1	487:492	Mutation rewiring degron network	0.3056
p.L486F	DO219482	SKCM	ICGC	MELHQE	LIG_APCC_ABBA_1	487:492	Mutation rewiring degron network	0.3056
p.N109K	TCGA-DK-A6AW	BLCA	TCGA	VKENS	DEG_APCC_KENBOX_2	106:110	Mutation altering degron motif	0.6918
p.N109K	DO48566	BLCA	ICGC	VKENS	DEG_APCC_KENBOX_2	106:110	Mutation altering degron motif	0.6918
p.S110P	TCGA-EB-A41A	SKCM	TCGA	VKENS	DEG_APCC_KENBOX_2	106:110	Mutation altering degron motif	0.6752
p.S110P	DO37429	SKCM	ICGC	VKENS	DEG_APCC_KENBOX_2	106:110	Mutation altering degron motif	0.6752
p.S110F	TCGA-EE-A2GI	SKCM	TCGA	VKENS	DEG_APCC_KENBOX_2	106:110	Mutation altering degron motif	0.7982
p.S110F	DO37410	SKCM	ICGC	VKENS	DEG_APCC_KENBOX_2	106:110	Mutation altering degron motif	0.7982
p.R116S	TCGA-EE-A2MG	SKCM	TCGA	VKENS	DEG_APCC_KENBOX_2	106:110	Mutation rewiring degron network	0.1667
p.R116S	TCGA-GN-A26D	SKCM	TCGA	VKENS	DEG_APCC_KENBOX_2	106:110	Mutation rewiring degron network	0.1667
p.R116S	DO37421	SKCM	ICGC	VKENS	DEG_APCC_KENBOX_2	106:110	Mutation rewiring degron network	0.1667
p.R116S	DO37480	SKCM	ICGC	VKENS	DEG_APCC_KENBOX_2	106:110	Mutation rewiring degron network	0.1667
p.E492K	DO229253	THCA	ICGC	MELHQE	LIG_APCC_ABBA_1	487:492	Mutation altering degron motif	0.7022
p.E488D	SIDM00789	Colorectal Carcinoma	GDSC	MELHQE	LIG_APCC_ABBA_1	487:492	Mutation altering degron motif	0.5647
p.E488D	HCT-15	large intestine	COSMIC	MELHQE	LIG_APCC_ABBA_1	487:492	Mutation altering degron motif	0.5647
p.K501T	SIDM00820	Kidney Carcinoma	GDSC	MELHQE	LIG_APCC_ABBA_1	487:492	Mutation substituting flanking lysine	0.1944
p.K501T	ACH-002188	Kidney Cancer	CCLE	MELHQE	LIG_APCC_ABBA_1	487:492	Mutation substituting flanking lysine	0.1944
p.K498N	SIDM00562	Breast Carcinoma	GDSC	MELHQE	LIG_APCC_ABBA_1	487:492	Mutation substituting flanking lysine	0.2778
p.K498N	ACH-002163	Breast Cancer	CCLE	MELHQE	LIG_APCC_ABBA_1	487:492	Mutation substituting flanking lysine	0.2778
p.E492G	SIDM01450	Gastric Carcinoma	GDSC	MELHQE	LIG_APCC_ABBA_1	487:492	Mutation altering degron motif	0.7199
p.E492G	ACH-000898	Gastric Cancer	CCLE	MELHQE	LIG_APCC_ABBA_1	487:492	Mutation altering degron motif	0.7199

Kaplan plot for SLU7 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLU7

UniProt ID: O95391

Entrez ID: 10569

Protein name: Pre-mRNA-splicing factor SLU7 (hSlu7)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SLU7 in