DegronMD

Uniprot ID: O95391

Source protein: Pre-mRNA-splicing factor SLU7

Source gene: SLU7

Class: DEG_APCC_KENBOX_2

Location: 106:110

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6647

ASA_SCORE: 90.68

COIL: 0.6956

CONS_SCORE: 0.5071

DSS_SCORE: 0.3907

HELIX: 0.2138

FCONS_SCORE: 0.787

RIG_SCORE: 0.7597

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R116H	TCGA-AP-A1DV	UCEC	TCGA	VKENS	DEG_APCC_KENBOX_2	0.1667
p.R116H	DO233088	GACA	ICGC	VKENS	DEG_APCC_KENBOX_2	0.1667
p.R116H	DO43186	UCEC	ICGC	VKENS	DEG_APCC_KENBOX_2	0.1667
p.R116C	TCGA-BG-A0M4	UCEC	TCGA	VKENS	DEG_APCC_KENBOX_2	0.1667
p.R116C	DO41686	UCEC	ICGC	VKENS	DEG_APCC_KENBOX_2	0.1667
p.N109K	TCGA-DK-A6AW	BLCA	TCGA	VKENS	DEG_APCC_KENBOX_2	0.6918
p.N109K	DO48566	BLCA	ICGC	VKENS	DEG_APCC_KENBOX_2	0.6918
p.S110P	TCGA-EB-A41A	SKCM	TCGA	VKENS	DEG_APCC_KENBOX_2	0.6752
p.S110P	DO37429	SKCM	ICGC	VKENS	DEG_APCC_KENBOX_2	0.6752
p.S110F	TCGA-EE-A2GI	SKCM	TCGA	VKENS	DEG_APCC_KENBOX_2	0.7982
p.S110F	DO37410	SKCM	ICGC	VKENS	DEG_APCC_KENBOX_2	0.7982
p.R116S	TCGA-EE-A2MG	SKCM	TCGA	VKENS	DEG_APCC_KENBOX_2	0.1667
p.R116S	TCGA-GN-A26D	SKCM	TCGA	VKENS	DEG_APCC_KENBOX_2	0.1667
p.R116S	DO37421	SKCM	ICGC	VKENS	DEG_APCC_KENBOX_2	0.1667
p.R116S	DO37480	SKCM	ICGC	VKENS	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95391	Pre-mRNA-splicing factor SLU7	DEG_APCC_KENBOX_2	106:110	VKENS	APC,CDC20,FZR1	0.6647	More...
Q15025	TNFAIP3-interacting protein 1	DEG_APCC_KENBOX_2	29:33	VKENS	APC,CDC20,FZR1	0.582	More...
P51815	Zinc finger protein 75D	DEG_APCC_KENBOX_2	26:30	VKENS	APC,CDC20,FZR1	0.6713	More...
Q8N7Z5	Ankyrin repeat domain-containing protein 31	DEG_APCC_KENBOX_2	894:898	VKENS	APC,CDC20,FZR1	0.9707	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons