DegronMD

Uniprot ID: P51815

Source protein: Zinc finger protein 75D

Source gene: ZNF75D

Class: DEG_APCC_KENBOX_2

Location: 26:30

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6713

ASA_SCORE: 83.88

COIL: 0.6182

CONS_SCORE: 0.6273

DSS_SCORE: 0.489

HELIX: 0.1282

FCONS_SCORE: 1.4523

RIG_SCORE: 0.646

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N29S	SIDM00878	Breast Carcinoma	GDSC	VKENS	DEG_APCC_KENBOX_2	0.7069
p.N29S	SIDM01588	Endometrial Carcinoma	GDSC	VKENS	DEG_APCC_KENBOX_2	0.7069
p.N29S	ACH-000930	Breast Cancer	CCLE	VKENS	DEG_APCC_KENBOX_2	0.7069
p.N29S	ACH-000993	Endometrial/Uterine Cancer	CCLE	VKENS	DEG_APCC_KENBOX_2	0.7069
p.N29S	HCC1569	breast	COSMIC	VKENS	DEG_APCC_KENBOX_2	0.7069
p.E28K	TCGA-UY-A78K	BLCA	TCGA	VKENS	DEG_APCC_KENBOX_2	0.7022
p.E28K	DO219031	BLCA	ICGC	VKENS	DEG_APCC_KENBOX_2	0.7022
p.S30F	SIDM01575	Plasma Cell Myeloma	GDSC	VKENS	DEG_APCC_KENBOX_2	0.6871
p.S30F	ACH-000426	Myeloma	CCLE	VKENS	DEG_APCC_KENBOX_2	0.6871
p.K35T	TCGA-F5-6814	READ	TCGA	VKENS	DEG_APCC_KENBOX_2	0.3056
p.K35T	DO36556	READ	ICGC	VKENS	DEG_APCC_KENBOX_2	0.3056
p.E21K	SIDM02019	Colorectal Carcinoma	GDSC	VKENS	DEG_APCC_KENBOX_2	0.1944
p.W20L	TCGA-85-A50Z	LUSC	TCGA	VKENS	DEG_APCC_KENBOX_2	0.1667
p.W20L	DO45462	LUSC	ICGC	VKENS	DEG_APCC_KENBOX_2	0.1667
p.Y36C	DO229126	NKTL	ICGC	VKENS	DEG_APCC_KENBOX_2	0.1667
p.A18V	SIDM01608	Endometrial Carcinoma	GDSC	VKENS	DEG_APCC_KENBOX_2	0.1111
p.A18V	ACH-000990	Endometrial/Uterine Cancer	CCLE	VKENS	DEG_APCC_KENBOX_2	0.1111
p.M16I	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VKENS	DEG_APCC_KENBOX_2	0.0556
p.M16I	ACH-000929	Lung Cancer	CCLE	VKENS	DEG_APCC_KENBOX_2	0.0556
p.M16I	NCI-H2110	lung	COSMIC	VKENS	DEG_APCC_KENBOX_2	0.0556

Showing 1 to 20 of 20 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N7Z5	Ankyrin repeat domain-containing protein 31	DEG_APCC_KENBOX_2	894:898	VKENS	APC,CDC20,FZR1	0.9707	More...
O95391	Pre-mRNA-splicing factor SLU7	DEG_APCC_KENBOX_2	106:110	VKENS	APC,CDC20,FZR1	0.6647	More...
Q15025	TNFAIP3-interacting protein 1	DEG_APCC_KENBOX_2	29:33	VKENS	APC,CDC20,FZR1	0.582	More...
P51815	Zinc finger protein 75D	DEG_APCC_KENBOX_2	26:30	VKENS	APC,CDC20,FZR1	0.6713	More...

Showing 1 to 4 of 4 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons