DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VKENS
Uniprot ID:
P51815
Source protein:
Zinc finger protein 75D
Source gene:
ZNF75D
Class:
DEG_APCC_KENBOX_2
Location:
26:30
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6713
ASA_SCORE:
83.88
COIL:
0.6182
CONS_SCORE:
0.6273
DSS_SCORE:
0.489
HELIX:
0.1282
FCONS_SCORE:
1.4523
RIG_SCORE:
0.646
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.W20L
TCGA-85-A50Z
LUSC
TCGA
VKENS
DEG_APCC_KENBOX_2
0.1667
p.W20L
DO45462
LUSC
ICGC
VKENS
DEG_APCC_KENBOX_2
0.1667
p.K35T
TCGA-F5-6814
READ
TCGA
VKENS
DEG_APCC_KENBOX_2
0.3056
p.K35T
DO36556
READ
ICGC
VKENS
DEG_APCC_KENBOX_2
0.3056
p.E28K
TCGA-UY-A78K
BLCA
TCGA
VKENS
DEG_APCC_KENBOX_2
0.7022
p.E28K
DO219031
BLCA
ICGC
VKENS
DEG_APCC_KENBOX_2
0.7022
p.Y36C
DO229126
NKTL
ICGC
VKENS
DEG_APCC_KENBOX_2
0.1667
p.E21K
SIDM02019
Colorectal Carcinoma
GDSC
VKENS
DEG_APCC_KENBOX_2
0.1944
p.N29S
SIDM00878
Breast Carcinoma
GDSC
VKENS
DEG_APCC_KENBOX_2
0.7069
p.N29S
SIDM01588
Endometrial Carcinoma
GDSC
VKENS
DEG_APCC_KENBOX_2
0.7069
p.N29S
ACH-000930
Breast Cancer
CCLE
VKENS
DEG_APCC_KENBOX_2
0.7069
p.N29S
ACH-000993
Endometrial/Uterine Cancer
CCLE
VKENS
DEG_APCC_KENBOX_2
0.7069
p.N29S
HCC1569
breast
COSMIC
VKENS
DEG_APCC_KENBOX_2
0.7069
p.M16I
SIDM00703
Non-Small Cell Lung Carcinoma
GDSC
VKENS
DEG_APCC_KENBOX_2
0.0556
p.M16I
ACH-000929
Lung Cancer
CCLE
VKENS
DEG_APCC_KENBOX_2
0.0556
p.M16I
NCI-H2110
lung
COSMIC
VKENS
DEG_APCC_KENBOX_2
0.0556
p.A18V
SIDM01608
Endometrial Carcinoma
GDSC
VKENS
DEG_APCC_KENBOX_2
0.1111
p.A18V
ACH-000990
Endometrial/Uterine Cancer
CCLE
VKENS
DEG_APCC_KENBOX_2
0.1111
p.S30F
SIDM01575
Plasma Cell Myeloma
GDSC
VKENS
DEG_APCC_KENBOX_2
0.6871
p.S30F
ACH-000426
Myeloma
CCLE
VKENS
DEG_APCC_KENBOX_2
0.6871
Drug responses associated with ZNF75D mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VKENS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95391
Pre-mRNA-splicing factor SLU7
DEG_APCC_KENBOX_2
106:110
VKENS
APC,CDC20,FZR1
0.6647
More...
Q15025
TNFAIP3-interacting protein 1
DEG_APCC_KENBOX_2
29:33
VKENS
APC,CDC20,FZR1
0.582
More...
P51815
Zinc finger protein 75D
DEG_APCC_KENBOX_2
26:30
VKENS
APC,CDC20,FZR1
0.6713
More...
Q8N7Z5
Ankyrin repeat domain-containing protein 31
DEG_APCC_KENBOX_2
894:898
VKENS
APC,CDC20,FZR1
0.9707
More...