DegronMD

Uniprot ID: Q15025

Source protein: TNFAIP3-interacting protein 1

Source gene: TNIP1

Class: DEG_APCC_KENBOX_2

Location: 29:33

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.582

ASA_SCORE: 84.18

COIL: 0.0586

CONS_SCORE: 0.5888

DSS_SCORE: 0.3938

HELIX: 0.9428

FCONS_SCORE: 1.1944

RIG_SCORE: 0.7823

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K38N	TCGA-B5-A0JY	UCEC	TCGA	VKENS	DEG_APCC_KENBOX_2	0.3056
p.K38N	DO43041	UCEC	ICGC	VKENS	DEG_APCC_KENBOX_2	0.3056
p.S22F	TCGA-XF-AAMX	BLCA	TCGA	VKENS	DEG_APCC_KENBOX_2	0.1389
p.S22F	DO51939	BLCA	ICGC	VKENS	DEG_APCC_KENBOX_2	0.1389
p.A23T	DO227882	PBCA	ICGC	VKENS	DEG_APCC_KENBOX_2	0.1667
p.R27H	SIDM00072	Non-Cancerous	GDSC	VKENS	DEG_APCC_KENBOX_2	0.2778
p.A23S	SIDM00968	Ovarian Carcinoma	GDSC	VKENS	DEG_APCC_KENBOX_2	0.1667
p.A23S	SIDM01215	Ovarian Carcinoma	GDSC	VKENS	DEG_APCC_KENBOX_2	0.1667
p.A23S	ACH-000542	Ovarian Cancer	CCLE	VKENS	DEG_APCC_KENBOX_2	0.1667
p.A23S	ACH-002140	Ovarian Cancer	CCLE	VKENS	DEG_APCC_KENBOX_2	0.1667
p.A23S	Hey	ovary	COSMIC	VKENS	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95391	Pre-mRNA-splicing factor SLU7	DEG_APCC_KENBOX_2	106:110	VKENS	APC,CDC20,FZR1	0.6647	More...
Q15025	TNFAIP3-interacting protein 1	DEG_APCC_KENBOX_2	29:33	VKENS	APC,CDC20,FZR1	0.582	More...
P51815	Zinc finger protein 75D	DEG_APCC_KENBOX_2	26:30	VKENS	APC,CDC20,FZR1	0.6713	More...
Q8N7Z5	Ankyrin repeat domain-containing protein 31	DEG_APCC_KENBOX_2	894:898	VKENS	APC,CDC20,FZR1	0.9707	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons