DegronMD - Q15025(TNIP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P432L	TCGA-26-1799	GBM	TCGA	IQTPPSS	DEG_SCF_FBW7_1	429:435	Mutation altering degron motif	0.7582
p.P432L	DO11603	GBM	ICGC	IQTPPSS	DEG_SCF_FBW7_1	429:435	Mutation altering degron motif	0.7582
p.G445V	TCGA-60-2698	LUSC	TCGA	IQTPPSS	DEG_SCF_FBW7_1	429:435	Mutation rewiring degron network	0.0556
p.G445V	DO26469	LUSC	ICGC	IQTPPSS	DEG_SCF_FBW7_1	429:435	Mutation rewiring degron network	0.0556
p.C545Y	TCGA-AX-A2IN	UCEC	TCGA	VEPHPE	LIG_APCC_ABBA_1	537:542	Mutation rewiring degron network	0.25
p.C545Y	DO42328	UCEC	ICGC	VEPHPE	LIG_APCC_ABBA_1	537:542	Mutation rewiring degron network	0.25
p.K38N	TCGA-B5-A0JY	UCEC	TCGA	VKENS	DEG_APCC_KENBOX_2	29:33	Mutation substituting flanking lysine	0.3056
p.K38N	DO43041	UCEC	ICGC	VKENS	DEG_APCC_KENBOX_2	29:33	Mutation substituting flanking lysine	0.3056
p.S22F	TCGA-XF-AAMX	BLCA	TCGA	VKENS	DEG_APCC_KENBOX_2	29:33	Mutation rewiring degron network	0.1389
p.S22F	DO51939	BLCA	ICGC	VKENS	DEG_APCC_KENBOX_2	29:33	Mutation rewiring degron network	0.1389
p.A426V	DO224796	COCA	ICGC	IQTPPSS	DEG_SCF_FBW7_1	429:435	Mutation rewiring degron network	0.25
p.A551T	DO222822	COCA	ICGC	VEPHPE	LIG_APCC_ABBA_1	537:542	Mutation rewiring degron network	0.0833
p.L427Q	DO233777	GACA	ICGC	IQTPPSS	DEG_SCF_FBW7_1	429:435	Mutation rewiring degron network	0.2778
p.S531P	DO233885	GACA	ICGC	VEPHPE	LIG_APCC_ABBA_1	537:542	Mutation rewiring degron network	0.1667
p.R534S	DO228952	LICA	ICGC	VEPHPE	LIG_APCC_ABBA_1	537:542	Mutation rewiring degron network	0.25
p.A528E	DO229018	LICA	ICGC	VEPHPE	LIG_APCC_ABBA_1	537:542	Mutation rewiring degron network	0.0833
p.A23T	DO227882	PBCA	ICGC	VKENS	DEG_APCC_KENBOX_2	29:33	Mutation rewiring degron network	0.1667
p.L547F	DO37847	SKCM	ICGC	VEPHPE	LIG_APCC_ABBA_1	537:542	Mutation rewiring degron network	0.1944
p.P530S	DO37818	SKCM	ICGC	VEPHPE	LIG_APCC_ABBA_1	537:542	Mutation rewiring degron network	0.1389
p.R27H	SIDM00072	Non-Cancerous	GDSC	VKENS	DEG_APCC_KENBOX_2	29:33	Mutation rewiring degron network	0.2778
p.A23S	SIDM00968	Ovarian Carcinoma	GDSC	VKENS	DEG_APCC_KENBOX_2	29:33	Mutation rewiring degron network	0.1667
p.A23S	SIDM01215	Ovarian Carcinoma	GDSC	VKENS	DEG_APCC_KENBOX_2	29:33	Mutation rewiring degron network	0.1667
p.A23S	ACH-000542	Ovarian Cancer	CCLE	VKENS	DEG_APCC_KENBOX_2	29:33	Mutation rewiring degron network	0.1667
p.A23S	ACH-002140	Ovarian Cancer	CCLE	VKENS	DEG_APCC_KENBOX_2	29:33	Mutation rewiring degron network	0.1667
p.A23S	Hey	ovary	COSMIC	VKENS	DEG_APCC_KENBOX_2	29:33	Mutation rewiring degron network	0.1667
p.T431A	SIDM00118	Colorectal Carcinoma	GDSC	IQTPPSS	DEG_SCF_FBW7_1	429:435	Mutation altering degron motif	0.825
p.T431A	ACH-001081	Colon/Colorectal Cancer	CCLE	IQTPPSS	DEG_SCF_FBW7_1	429:435	Mutation altering degron motif	0.825
p.T431A	HCC2998	large intestine	COSMIC	IQTPPSS	DEG_SCF_FBW7_1	429:435	Mutation altering degron motif	0.825
p.S428C	SIDM01450	Gastric Carcinoma	GDSC	IQTPPSS	DEG_SCF_FBW7_1	429:435	Mutation rewiring degron network	0.3056
p.S428C	ACH-000898	Gastric Cancer	CCLE	IQTPPSS	DEG_SCF_FBW7_1	429:435	Mutation rewiring degron network	0.3056
p.Y552S	ACH-000832	Head and Neck Cancer	CCLE	VEPHPE	LIG_APCC_ABBA_1	537:542	Mutation blocking phosphorylation signal	0.5
p.Y552S	CAL-27	upper aerodigestive tract	COSMIC	VEPHPE	LIG_APCC_ABBA_1	537:542	Mutation blocking phosphorylation signal	0.5
p.L423V	ACH-001856	Bile Duct Cancer	CCLE	IQTPPSS	DEG_SCF_FBW7_1	429:435	Mutation rewiring degron network	0.1667
p.V536M	HCC1419	breast	COSMIC	VEPHPE	LIG_APCC_ABBA_1	537:542	Mutation rewiring degron network	0.3056
p.T542N	HCC-366	lung	COSMIC	VEPHPE	LIG_APCC_ABBA_1	537:542	Mutation altering degron motif	0.7055

Kaplan plot for TNIP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNIP1

UniProt ID: Q15025

Entrez ID: 10318

Protein name: TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNIP1 in