DegronMD

Uniprot ID: Q15025

Source protein: TNFAIP3-interacting protein 1

Source gene: TNIP1

Class: LIG_APCC_ABBA_1

Location: 537:542

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7605

ASA_SCORE: 93.8667

COIL: 0.9023

CONS_SCORE: 0.4475

DSS_SCORE: 0.4184

HELIX: 0.0802

FCONS_SCORE: 1.0224

RIG_SCORE: 0.6585

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C545Y	TCGA-AX-A2IN	UCEC	TCGA	VEPHPE	LIG_APCC_ABBA_1	0.25
p.C545Y	DO42328	UCEC	ICGC	VEPHPE	LIG_APCC_ABBA_1	0.25
p.A551T	DO222822	COCA	ICGC	VEPHPE	LIG_APCC_ABBA_1	0.0833
p.S531P	DO233885	GACA	ICGC	VEPHPE	LIG_APCC_ABBA_1	0.1667
p.R534S	DO228952	LICA	ICGC	VEPHPE	LIG_APCC_ABBA_1	0.25
p.A528E	DO229018	LICA	ICGC	VEPHPE	LIG_APCC_ABBA_1	0.0833
p.L547F	DO37847	SKCM	ICGC	VEPHPE	LIG_APCC_ABBA_1	0.1944
p.P530S	DO37818	SKCM	ICGC	VEPHPE	LIG_APCC_ABBA_1	0.1389
p.Y552S	ACH-000832	Head and Neck Cancer	CCLE	VEPHPE	LIG_APCC_ABBA_1	0.5
p.Y552S	CAL-27	upper_aerodigestive_tract	COSMIC	VEPHPE	LIG_APCC_ABBA_1	0.5
p.V536M	HCC1419	breast	COSMIC	VEPHPE	LIG_APCC_ABBA_1	0.3056
p.T542N	HCC-366	lung	COSMIC	VEPHPE	LIG_APCC_ABBA_1	0.7055

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15025	TNFAIP3-interacting protein 1	LIG_APCC_ABBA_1	537:542	VEPHPE	APC,CDC20,FZR1	0.7605	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons