DegronMD

Uniprot ID: Q15025

Source protein: TNFAIP3-interacting protein 1

Source gene: TNIP1

Class: DEG_SCF_FBW7_1

Location: 429:435

E3 ligase: FBXW7

DEGRON score: 0.9905

ASA_SCORE: 101.4571

COIL: 0.9617

CONS_SCORE: 0.4617

DSS_SCORE: 0.6765

HELIX: 0.0271

FCONS_SCORE: 0.8066

RIG_SCORE: 0.5914

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P432L	TCGA-26-1799	GBM	TCGA	IQTPPSS	DEG_SCF_FBW7_1	0.7582
p.P432L	DO11603	GBM	ICGC	IQTPPSS	DEG_SCF_FBW7_1	0.7582
p.G445V	TCGA-60-2698	LUSC	TCGA	IQTPPSS	DEG_SCF_FBW7_1	0.0556
p.G445V	DO26469	LUSC	ICGC	IQTPPSS	DEG_SCF_FBW7_1	0.0556
p.A426V	DO224796	COCA	ICGC	IQTPPSS	DEG_SCF_FBW7_1	0.25
p.L427Q	DO233777	GACA	ICGC	IQTPPSS	DEG_SCF_FBW7_1	0.2778
p.T431A	SIDM00118	Colorectal Carcinoma	GDSC	IQTPPSS	DEG_SCF_FBW7_1	0.825
p.T431A	ACH-001081	Colon/Colorectal Cancer	CCLE	IQTPPSS	DEG_SCF_FBW7_1	0.825
p.T431A	HCC2998	large_intestine	COSMIC	IQTPPSS	DEG_SCF_FBW7_1	0.825
p.S428C	SIDM01450	Gastric Carcinoma	GDSC	IQTPPSS	DEG_SCF_FBW7_1	0.3056
p.S428C	ACH-000898	Gastric Cancer	CCLE	IQTPPSS	DEG_SCF_FBW7_1	0.3056
p.L423V	ACH-001856	Bile Duct Cancer	CCLE	IQTPPSS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15025	TNFAIP3-interacting protein 1	DEG_SCF_FBW7_1	429:435	IQTPPSS	FBXW7	0.9905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons