DegronMD

Uniprot ID: O95391

Source protein: Pre-mRNA-splicing factor SLU7

Source gene: SLU7

Class: LIG_APCC_ABBA_1

Location: 487:492

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6526

ASA_SCORE: 98.0667

COIL: 0.1527

CONS_SCORE: 0.4318

DSS_SCORE: 0.5603

HELIX: 0.8492

FCONS_SCORE: 1.0122

RIG_SCORE: 0.7652

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L486F	TCGA-DA-A960	SKCM	TCGA	MELHQE	LIG_APCC_ABBA_1	0.3056
p.L486F	DO219482	SKCM	ICGC	MELHQE	LIG_APCC_ABBA_1	0.3056
p.E492K	DO229253	THCA	ICGC	MELHQE	LIG_APCC_ABBA_1	0.7022
p.E488D	SIDM00789	Colorectal Carcinoma	GDSC	MELHQE	LIG_APCC_ABBA_1	0.5647
p.E488D	HCT-15	large_intestine	COSMIC	MELHQE	LIG_APCC_ABBA_1	0.5647
p.K501T	SIDM00820	Kidney Carcinoma	GDSC	MELHQE	LIG_APCC_ABBA_1	0.1944
p.K501T	ACH-002188	Kidney Cancer	CCLE	MELHQE	LIG_APCC_ABBA_1	0.1944
p.K498N	SIDM00562	Breast Carcinoma	GDSC	MELHQE	LIG_APCC_ABBA_1	0.2778
p.K498N	ACH-002163	Breast Cancer	CCLE	MELHQE	LIG_APCC_ABBA_1	0.2778
p.E492G	SIDM01450	Gastric Carcinoma	GDSC	MELHQE	LIG_APCC_ABBA_1	0.7199
p.E492G	ACH-000898	Gastric Cancer	CCLE	MELHQE	LIG_APCC_ABBA_1	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95391	Pre-mRNA-splicing factor SLU7	LIG_APCC_ABBA_1	487:492	MELHQE	APC,CDC20,FZR1	0.6526	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons