DegronMD

Uniprot ID: Q8N7Z5

Source protein: Ankyrin repeat domain-containing protein 31

Source gene: ANKRD31

Class: LIG_APCC_ABBA_1

Location: 143:148

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.905

ASA_SCORE: 63.5667

COIL: 0.6328

CONS_SCORE: 0.5304

DSS_SCORE: 0.6554

HELIX: 0.2927

FCONS_SCORE: 1.0552

RIG_SCORE: 0.731

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E150K	TCGA-AP-A1DV	UCEC	TCGA	VLPHIE	LIG_APCC_ABBA_1	0.2778
p.E150K	DO43186	UCEC	ICGC	VLPHIE	LIG_APCC_ABBA_1	0.2778
p.E134G	TCGA-EO-A22S	UCEC	TCGA	VLPHIE	LIG_APCC_ABBA_1	0.0833
p.E134G	DO41590	UCEC	ICGC	VLPHIE	LIG_APCC_ABBA_1	0.0833
p.D156N	DO10172	COAD	ICGC	VLPHIE	LIG_APCC_ABBA_1	0.1111
p.A138D	DO233762	GACA	ICGC	VLPHIE	LIG_APCC_ABBA_1	0.1944
p.L151I	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VLPHIE	LIG_APCC_ABBA_1	0.25
p.L151I	ACH-000981	Leukemia	CCLE	VLPHIE	LIG_APCC_ABBA_1	0.25
p.L151I	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	VLPHIE	LIG_APCC_ABBA_1	0.25
p.S157Y	ACH-000820	Colon/Colorectal Cancer	CCLE	VLPHIE	LIG_APCC_ABBA_1	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N7Z5	Ankyrin repeat domain-containing protein 31	LIG_APCC_ABBA_1	143:148	VLPHIE	APC,CDC20,FZR1	0.905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons