DegronMD

Uniprot ID: Q8N7Z5

Source protein: Ankyrin repeat domain-containing protein 31

Source gene: ANKRD31

Class: DEG_APCC_KENBOX_2

Location: 930:934

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.661

ASA_SCORE: 101.48

COIL: 0.5698

CONS_SCORE: 0.401

DSS_SCORE: 0.3883

HELIX: 0.2036

FCONS_SCORE: 1

RIG_SCORE: 0.7994

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H927N	DO229015	LICA	ICGC	FKENL	DEG_APCC_KENBOX_2	0.25
p.Q944H	DO46392	OV	ICGC	FKENL	DEG_APCC_KENBOX_2	0.0556
p.E939K	DO47542	SKCM	ICGC	FKENL	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N7Z5	Ankyrin repeat domain-containing protein 31	DEG_APCC_KENBOX_2	930:934	FKENL	APC,CDC20,FZR1	0.661	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons