DegronMD

Uniprot ID: Q8N7Z5

Source protein: Ankyrin repeat domain-containing protein 31

Source gene: ANKRD31

Class: DEG_APCC_KENBOX_2

Location: 1560:1564

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6997

ASA_SCORE: 100.76

COIL: 0.5442

CONS_SCORE: 0.5082

DSS_SCORE: 0.5866

HELIX: 0.3416

FCONS_SCORE: 1.0568

RIG_SCORE: 0.7315

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1566R	DO229005	COCA	ICGC	QKEND	DEG_APCC_KENBOX_2	0.2778
p.T1566R	DO229480	LAML	ICGC	QKEND	DEG_APCC_KENBOX_2	0.2778
p.D1573N	ACH-001550	Skin Cancer	CCLE	QKEND	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N1H7	Protein SIX6OS1	DEG_APCC_KENBOX_2	318:322	QKEND	APC,CDC20,FZR1	0.8637	More...
Q96SN8	CDK5 regulatory subunit-associated protein 2	DEG_APCC_KENBOX_2	1474:1478	QKEND	APC,CDC20,FZR1	0.7395	More...
Q8N7Z5	Ankyrin repeat domain-containing protein 31	DEG_APCC_KENBOX_2	1560:1564	QKEND	APC,CDC20,FZR1	0.6997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons