DegronMD - Q8N1H7(SIX6OS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A459T	TCGA-2F-A9KR	BLCA	TCGA	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.1389
p.A459T	DO51862	BLCA	ICGC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.1389
p.T448P	TCGA-AA-3984	COAD	TCGA	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.7031
p.T448P	DO9002	COAD	ICGC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.7031
p.E452K	TCGA-AX-A05Z	UCEC	TCGA	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.7022
p.E452K	TCGA-D1-A16X	UCEC	TCGA	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.7022
p.E452K	TCGA-EE-A3AE	SKCM	TCGA	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.7022
p.E452K	TCGA-ER-A19F	SKCM	TCGA	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.7022
p.E452K	DO230316	COCA	ICGC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.7022
p.E452K	DO37679	SKCM	ICGC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.7022
p.E452K	DO37802	SKCM	ICGC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.7022
p.E452K	DO40884	UCEC	ICGC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.7022
p.E452K	DO41799	UCEC	ICGC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation altering degron motif	0.7022
p.R455K	TCGA-B5-A1MR	UCEC	TCGA	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.25
p.R455K	TCGA-EI-6917	READ	TCGA	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.25
p.R455K	DO36881	READ	ICGC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.25
p.R455K	DO41758	UCEC	ICGC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.25
p.D322N	TCGA-BF-A5EQ	SKCM	TCGA	QKEND	DEG_APCC_KENBOX_2	318:322	Mutation altering degron motif	0.5821
p.D322N	TCGA-EE-A3AC	SKCM	TCGA	QKEND	DEG_APCC_KENBOX_2	318:322	Mutation altering degron motif	0.5821
p.D322N	DO37631	SKCM	ICGC	QKEND	DEG_APCC_KENBOX_2	318:322	Mutation altering degron motif	0.5821
p.D322N	DO219452	SKCM	ICGC	QKEND	DEG_APCC_KENBOX_2	318:322	Mutation altering degron motif	0.5821
p.P437L	TCGA-ER-A42L	SKCM	TCGA	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.0833
p.P437L	DO223910	SKCM	ICGC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.0833
p.R455I	TCGA-F5-6814	READ	TCGA	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.25
p.R455I	TCGA-IQ-A61O	HNSC	TCGA	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.25
p.R455I	DO44432	HNSC	ICGC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.25
p.R455I	DO36556	READ	ICGC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.25
p.F445I	TCGA-FI-A2CX	UCEC	TCGA	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.3056
p.F445I	DO41283	UCEC	ICGC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.3056
p.T323A	TCGA-FI-A2D6	UCEC	TCGA	QKEND	DEG_APCC_KENBOX_2	318:322	Mutation rewiring degron network	0.3056
p.T323A	DO43867	UCEC	ICGC	QKEND	DEG_APCC_KENBOX_2	318:322	Mutation rewiring degron network	0.3056
p.N327D	DO231649	LINC	ICGC	QKEND	DEG_APCC_KENBOX_2	318:322	Mutation rewiring degron network	0.1944
p.K319Q	SIDM01300	Colorectal Carcinoma	GDSC	QKEND	DEG_APCC_KENBOX_2	318:322	Mutation altering degron motif	0.6944
p.R457I	SIDM00683	Prostate Carcinoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.1944
p.R457I	ACH-000977	lymph node	CCLE	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.1944
p.E462D	SIDM01123	Prostate Carcinoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.0556
p.E462D	SIDM00933	Breast Carcinoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.0556
p.E462D	SIDM00392	Melanoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.0556
p.E462D	SIDM00198	Ewing's Sarcoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.0556
p.E462D	SIDM01087	Melanoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.0556
p.E462D	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.0556
p.E462D	SIDM01009	Neuroblastoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.0556
p.E462D	SIDM00201	Ewing's Sarcoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.0556
p.E462D	SIDM01316	Ewing's Sarcoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.0556
p.E462D	SIDM01325	Pancreatic Carcinoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.0556
p.D315E	SIDM00437	Acute Myeloid Leukemia	GDSC	QKEND	DEG_APCC_KENBOX_2	318:322	Mutation rewiring degron network	0.25
p.D315E	SIDM00338	Acute Myeloid Leukemia	GDSC	QKEND	DEG_APCC_KENBOX_2	318:322	Mutation rewiring degron network	0.25
p.D315E	SIDM00216	Colorectal Carcinoma	GDSC	QKEND	DEG_APCC_KENBOX_2	318:322	Mutation rewiring degron network	0.25
p.D315E	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	QKEND	DEG_APCC_KENBOX_2	318:322	Mutation rewiring degron network	0.25
p.D315E	SIDM00619	Thyroid Gland Carcinoma	GDSC	QKEND	DEG_APCC_KENBOX_2	318:322	Mutation rewiring degron network	0.25
p.D315E	SIDM01217	Other Blood Cancers	GDSC	QKEND	DEG_APCC_KENBOX_2	318:322	Mutation rewiring degron network	0.25
p.D315E	SIDM01372	Pancreatic Carcinoma	GDSC	QKEND	DEG_APCC_KENBOX_2	318:322	Mutation rewiring degron network	0.25
p.D315E	SIDM01588	Endometrial Carcinoma	GDSC	QKEND	DEG_APCC_KENBOX_2	318:322	Mutation rewiring degron network	0.25
p.F445L	SIDM00672	Hepatocellular Carcinoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.3056
p.F445L	SIDM01117	Small Cell Lung Carcinoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.3056
p.T323I	SIDM01263	T-Lymphoblastic Leukemia	GDSC	QKEND	DEG_APCC_KENBOX_2	318:322	Mutation rewiring degron network	0.3056
p.P437S	SIDM00254	Neuroblastoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.0833
p.P437S	SIDM01318	Hepatocellular Carcinoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	446:452	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SIX6OS1

UniProt ID: Q8N1H7

Entrez ID: 317761

Protein name: Protein SIX6OS1 (Six6 opposite strand transcript 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SIX6OS1 in