DegronMD

Uniprot ID: Q8N1H7

Source protein: Protein SIX6OS1

Source gene: SIX6OS1

Class: DEG_SCF_FBW7_2

Location: 446:452

E3 ligase: FBXW7

DEGRON score: 0.9801

ASA_SCORE: 92.1

COIL: 0.9274

CONS_SCORE: 0.5264

DSS_SCORE: 0.4978

HELIX: 0.0274

FCONS_SCORE: 1.2524

RIG_SCORE: 0.7362

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A459T	TCGA-2F-A9KR	BLCA	TCGA	PKTPPFE	DEG_SCF_FBW7_2	0.1389
p.A459T	DO51862	BLCA	ICGC	PKTPPFE	DEG_SCF_FBW7_2	0.1389
p.T448P	TCGA-AA-3984	COAD	TCGA	PKTPPFE	DEG_SCF_FBW7_2	0.7031
p.T448P	DO9002	COAD	ICGC	PKTPPFE	DEG_SCF_FBW7_2	0.7031
p.E452K	TCGA-AX-A05Z	UCEC	TCGA	PKTPPFE	DEG_SCF_FBW7_2	0.7022
p.E452K	TCGA-D1-A16X	UCEC	TCGA	PKTPPFE	DEG_SCF_FBW7_2	0.7022
p.E452K	TCGA-EE-A3AE	SKCM	TCGA	PKTPPFE	DEG_SCF_FBW7_2	0.7022
p.E452K	TCGA-ER-A19F	SKCM	TCGA	PKTPPFE	DEG_SCF_FBW7_2	0.7022
p.E452K	DO230316	COCA	ICGC	PKTPPFE	DEG_SCF_FBW7_2	0.7022
p.E452K	DO37679	SKCM	ICGC	PKTPPFE	DEG_SCF_FBW7_2	0.7022
p.E452K	DO37802	SKCM	ICGC	PKTPPFE	DEG_SCF_FBW7_2	0.7022
p.E452K	DO40884	UCEC	ICGC	PKTPPFE	DEG_SCF_FBW7_2	0.7022
p.E452K	DO41799	UCEC	ICGC	PKTPPFE	DEG_SCF_FBW7_2	0.7022
p.R455K	TCGA-B5-A1MR	UCEC	TCGA	PKTPPFE	DEG_SCF_FBW7_2	0.25
p.R455K	TCGA-EI-6917	READ	TCGA	PKTPPFE	DEG_SCF_FBW7_2	0.25
p.R455K	DO36881	READ	ICGC	PKTPPFE	DEG_SCF_FBW7_2	0.25
p.R455K	DO41758	UCEC	ICGC	PKTPPFE	DEG_SCF_FBW7_2	0.25
p.P437L	TCGA-ER-A42L	SKCM	TCGA	PKTPPFE	DEG_SCF_FBW7_2	0.0833
p.P437L	DO223910	SKCM	ICGC	PKTPPFE	DEG_SCF_FBW7_2	0.0833
p.R455I	TCGA-F5-6814	READ	TCGA	PKTPPFE	DEG_SCF_FBW7_2	0.25
p.R455I	TCGA-IQ-A61O	HNSC	TCGA	PKTPPFE	DEG_SCF_FBW7_2	0.25
p.R455I	DO44432	HNSC	ICGC	PKTPPFE	DEG_SCF_FBW7_2	0.25
p.R455I	DO36556	READ	ICGC	PKTPPFE	DEG_SCF_FBW7_2	0.25
p.F445I	TCGA-FI-A2CX	UCEC	TCGA	PKTPPFE	DEG_SCF_FBW7_2	0.3056
p.F445I	DO41283	UCEC	ICGC	PKTPPFE	DEG_SCF_FBW7_2	0.3056
p.R457I	SIDM00683	Prostate Carcinoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	0.1944
p.R457I	ACH-000977	lymph_node	CCLE	PKTPPFE	DEG_SCF_FBW7_2	0.1944
p.E462D	SIDM01123	Prostate Carcinoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	0.0556
p.E462D	SIDM00933	Breast Carcinoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	0.0556
p.E462D	SIDM00392	Melanoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	0.0556
p.E462D	SIDM00198	Ewing's Sarcoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	0.0556
p.E462D	SIDM01087	Melanoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	0.0556
p.E462D	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	0.0556
p.E462D	SIDM01009	Neuroblastoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	0.0556
p.E462D	SIDM00201	Ewing's Sarcoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	0.0556
p.E462D	SIDM01316	Ewing's Sarcoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	0.0556
p.E462D	SIDM01325	Pancreatic Carcinoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	0.0556
p.F445L	SIDM00672	Hepatocellular Carcinoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	0.3056
p.F445L	SIDM01117	Small Cell Lung Carcinoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	0.3056
p.P437S	SIDM00254	Neuroblastoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	0.0833
p.P437S	SIDM01318	Hepatocellular Carcinoma	GDSC	PKTPPFE	DEG_SCF_FBW7_2	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKTPPFE

Degron related mutations and impact score

Drug responses associated with SIX6OS1 mutations

All proteins holding degron of PKTPPFE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N1H7	Protein SIX6OS1	DEG_SCF_FBW7_2	446:452	PKTPPFE	FBXW7	0.9801	More...