DegronMD

Uniprot ID: Q8N7Z5

Source protein: Ankyrin repeat domain-containing protein 31

Source gene: ANKRD31

Class: LIG_APCC_ABBAyCdc20_2

Location: 484:490

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8377

ASA_SCORE: 82.0429

COIL: 0.8439

CONS_SCORE: 0.8015

DSS_SCORE: 0.1485

HELIX: 0.0434

FCONS_SCORE: 1.2441

RIG_SCORE: 0.8128

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N491K	TCGA-B5-A1MR	UCEC	TCGA	RRNIFGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.N491K	DO41758	UCEC	ICGC	RRNIFGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.D500N	TCGA-D1-A16J	UCEC	TCGA	RRNIFGE	LIG_APCC_ABBAyCdc20_2	0.0556
p.D500N	DO43033	UCEC	ICGC	RRNIFGE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E490D	TCGA-EO-A3AV	UCEC	TCGA	RRNIFGE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E490D	DO52412	UCEC	ICGC	RRNIFGE	LIG_APCC_ABBAyCdc20_2	0.5647
p.A497D	DO229024	LICA	ICGC	RRNIFGE	LIG_APCC_ABBAyCdc20_2	0.1389
p.K476E	DO44978	LIHC	ICGC	RRNIFGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.G489E	DO220891	MELA	ICGC	RRNIFGE	LIG_APCC_ABBAyCdc20_2	0.6087
p.R484Q	SIDM00201	Ewing's Sarcoma	GDSC	RRNIFGE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R484Q	ACH-002119	Bone Cancer	CCLE	RRNIFGE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R484Q	EW-7	bone	COSMIC	RRNIFGE	LIG_APCC_ABBAyCdc20_2	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N7Z5	Ankyrin repeat domain-containing protein 31	LIG_APCC_ABBAyCdc20_2	484:490	RRNIFGE	APC,CDC20,FZR1	0.8377	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons