DegronMD

Uniprot ID: Q8N3F8

Source protein: MICAL-like protein 1

Source gene: MICALL1

Class: DEG_SCF_FBW7_1

Location: 352:359

E3 ligase: FBXW7

DEGRON score: 0.9979

ASA_SCORE: 97.55

COIL: 0.9624

CONS_SCORE: 0.3768

DSS_SCORE: 0.7838

HELIX: 0.0171

FCONS_SCORE: 1.034

RIG_SCORE: 0.5258

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E346G	DO227709	COCA	ICGC	PRGTPKPS	DEG_SCF_FBW7_1	0.1667
p.E360D	DO228978	LICA	ICGC	PRGTPKPS	DEG_SCF_FBW7_1	0.3056
p.G342R	DO229121	THCA	ICGC	PRGTPKPS	DEG_SCF_FBW7_1	0.0556
p.R353K	SIDM00625	Other Sarcomas	GDSC	PRGTPKPS	DEG_SCF_FBW7_1	0.6126
p.R353K	ACH-000449	Sarcoma	CCLE	PRGTPKPS	DEG_SCF_FBW7_1	0.6126
p.R353K	MES-SA	soft_tissue	COSMIC	PRGTPKPS	DEG_SCF_FBW7_1	0.6126
p.P350S	SIDM01878	Non-Cancerous	GDSC	PRGTPKPS	DEG_SCF_FBW7_1	0.2778
p.P350S	SIDM00053	Pancreatic Carcinoma	GDSC	PRGTPKPS	DEG_SCF_FBW7_1	0.2778
p.P350S	ACH-002360	Non-Cancerous	CCLE	PRGTPKPS	DEG_SCF_FBW7_1	0.2778
p.L344R	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRGTPKPS	DEG_SCF_FBW7_1	0.1111
p.L344R	SIDM01526	Mesothelioma	GDSC	PRGTPKPS	DEG_SCF_FBW7_1	0.1111
p.L344R	JEKO-1	haematopoietic_and_lymphoid_tissue	COSMIC	PRGTPKPS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3F8	MICAL-like protein 1	DEG_SCF_FBW7_1	352:359	PRGTPKPS	FBXW7	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons