DegronMD

Uniprot ID: Q8N3F8

Source protein: MICAL-like protein 1

Source gene: MICALL1

Class: DEG_SCF_FBW7_1

Location: 466:471

E3 ligase: FBXW7

DEGRON score: 0.9745

ASA_SCORE: 87.4

COIL: 0.9382

CONS_SCORE: 0.3686

DSS_SCORE: 0.6582

HELIX: 0.0158

FCONS_SCORE: 0.799

RIG_SCORE: 0.6291

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T456A	TCGA-2W-A8YY	CESC	TCGA	ITPTSS	DEG_SCF_FBW7_1	0.0556
p.T456A	DO223732	CESC	ICGC	ITPTSS	DEG_SCF_FBW7_1	0.0556
p.R477C	TCGA-77-A5GF	LUSC	TCGA	ITPTSS	DEG_SCF_FBW7_1	0.1667
p.R477C	DO50101	LUSC	ICGC	ITPTSS	DEG_SCF_FBW7_1	0.1667
p.R477C	SIDM00216	Colorectal Carcinoma	GDSC	ITPTSS	DEG_SCF_FBW7_1	0.1667
p.P478H	TCGA-DU-7298	LGG	TCGA	ITPTSS	DEG_SCF_FBW7_1	0.1389
p.P478H	DO22679	LGG	ICGC	ITPTSS	DEG_SCF_FBW7_1	0.1389
p.P462S	TCGA-ER-A19F	SKCM	TCGA	ITPTSS	DEG_SCF_FBW7_1	0.2222
p.P462S	DO37679	SKCM	ICGC	ITPTSS	DEG_SCF_FBW7_1	0.2222
p.R481H	TCGA-HU-A4GX	STAD	TCGA	ITPTSS	DEG_SCF_FBW7_1	0.0556
p.R481H	DO233206	GACA	ICGC	ITPTSS	DEG_SCF_FBW7_1	0.0556
p.R481H	DO47757	STAD	ICGC	ITPTSS	DEG_SCF_FBW7_1	0.0556
p.P480L	TCGA-VQ-A8P5	STAD	TCGA	ITPTSS	DEG_SCF_FBW7_1	0.0833
p.P480L	DO51763	STAD	ICGC	ITPTSS	DEG_SCF_FBW7_1	0.0833
p.W463C	DO48451	BLCA	ICGC	ITPTSS	DEG_SCF_FBW7_1	0.25
p.W463C	DO229031	LICA	ICGC	ITPTSS	DEG_SCF_FBW7_1	0.25
p.P480Q	DO227657	COCA	ICGC	ITPTSS	DEG_SCF_FBW7_1	0.0833
p.S470I	DO50917	LICA	ICGC	ITPTSS	DEG_SCF_FBW7_1	0.7341
p.P472L	DO50727	ORCA	ICGC	ITPTSS	DEG_SCF_FBW7_1	0.3056
p.R477H	SIDM00980	Gastric Carcinoma	GDSC	ITPTSS	DEG_SCF_FBW7_1	0.1667
p.R477H	ACH-000948	Gastric Cancer	CCLE	ITPTSS	DEG_SCF_FBW7_1	0.1667
p.R477H	23132-87	stomach	COSMIC	ITPTSS	DEG_SCF_FBW7_1	0.1667
p.S470N	ACH-001377	Pancreatic Cancer	CCLE	ITPTSS	DEG_SCF_FBW7_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3F8	MICAL-like protein 1	DEG_SCF_FBW7_1	466:471	ITPTSS	FBXW7	0.9745	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons