DegronMD

Uniprot ID: A7E2F4

Source protein: Golgin subfamily A member 8A

Source gene: GOLGA8A

Class: DEG_SPOP_SBC_1

Location: 83:87

E3 ligase: SPOP

DEGRON score: 0.7895

ASA_SCORE: 100.7

COIL: 0.9054

CONS_SCORE: 0

DSS_SCORE: 0.5869

HELIX: 0.0706

FCONS_SCORE: 0

RIG_SCORE: 0.5573

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S80L	TCGA-AX-A0J0	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	0.25
p.S80L	TCGA-D1-A17Q	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	0.25
p.S80L	TCGA-EY-A1GI	UCEC	TCGA	PKSSS	DEG_SPOP_SBC_1	0.25
p.S80L	DO41903	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.25
p.S80L	DO41211	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.25
p.S80L	DO41133	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.25
p.S82F	TCGA-XK-AAIW	PRAD	TCGA	PKSSS	DEG_SPOP_SBC_1	0.3056
p.S82F	DO51407	PRAD	ICGC	PKSSS	DEG_SPOP_SBC_1	0.3056
p.E73G	DO227987	COCA	ICGC	PKSSS	DEG_SPOP_SBC_1	0.0556
p.R87G	DO51012	LAML	ICGC	PKSSS	DEG_SPOP_SBC_1	0.7568
p.R87G	ACH-000074	Leukemia	CCLE	PKSSS	DEG_SPOP_SBC_1	0.7568
p.R87G	ACH-000459	Kidney Cancer	CCLE	PKSSS	DEG_SPOP_SBC_1	0.7568
p.R87G	ACH-000507	Gastric Cancer	CCLE	PKSSS	DEG_SPOP_SBC_1	0.7568
p.R87G	ACH-000622	Brain Cancer	CCLE	PKSSS	DEG_SPOP_SBC_1	0.7568
p.R87G	ACH-000809	Esophageal Cancer	CCLE	PKSSS	DEG_SPOP_SBC_1	0.7568
p.D90N	DO229053	LICA	ICGC	PKSSS	DEG_SPOP_SBC_1	0.25
p.N89K	DO229053	LICA	ICGC	PKSSS	DEG_SPOP_SBC_1	0.2778
p.R81W	DO218843	SKCA	ICGC	PKSSS	DEG_SPOP_SBC_1	0.2778
p.Q74R	DO229218	THCA	ICGC	PKSSS	DEG_SPOP_SBC_1	0.0833
p.P85L	ACH-000177	Prostate Cancer	CCLE	PKSSS	DEG_SPOP_SBC_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15085	Rho guanine nucleotide exchange factor 11	DEG_SPOP_SBC_1	543:547	PKSSS	SPOP	0.7465	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1015:1019	PKSSS	SPOP	0.8719	More...
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	564:568	PKSSS	SPOP	0.9922	More...
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	289:293	PKSSS	SPOP	0.9956	More...
Q15811	Intersectin-1	DEG_SPOP_SBC_1	180:184	PKSSS	SPOP	0.9976	More...
Q5T200	Zinc finger CCCH domain-containing protein 13	DEG_SPOP_SBC_1	225:229	PKSSS	SPOP	0.9834	More...
Q5TCZ1	SH3 and PX domain-containing protein 2A	DEG_SPOP_SBC_1	663:667	PKSSS	SPOP	0.8452	More...
Q6DN12	Multiple C2 and transmembrane domain-containing protein 2	DEG_SPOP_SBC_1	89:93	PKSSS	SPOP	0.7468	More...
Q7L590	Protein MCM10 homolog	DEG_SPOP_SBC_1	200:204	PKSSS	SPOP	0.9805	More...
Q8N3F8	MICAL-like protein 1	DEG_SPOP_SBC_1	534:538	PKSSS	SPOP	0.9952	More...
Q8WYP5	Protein ELYS	DEG_SPOP_SBC_1	1340:1344	PKSSS	SPOP	0.9617	More...
Q96QS3	Homeobox protein ARX	DEG_SPOP_SBC_1	68:72	PKSSS	SPOP	0.583	More...
Q9NXV6	CDKN2A-interacting protein	DEG_SPOP_SBC_1	347:351	PKSSS	SPOP	0.9905	More...
Q9Y2I7	1-phosphatidylinositol 3-phosphate 5-kinase	DEG_SPOP_SBC_1	1710:1714	PKSSS	SPOP	0.9961	More...
Q9Y5X1	Sorting nexin-9	DEG_SPOP_SBC_1	172:176	PKSSS	SPOP	0.9854	More...
A6NHQ2	rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1	DEG_SPOP_SBC_1	329:333	PKSSS	SPOP	0.72	More...
A7E2F4	Golgin subfamily A member 8A	DEG_SPOP_SBC_1	83:87	PKSSS	SPOP	0.7895	More...
Q5H9T9	Fibrous sheath CABYR-binding protein	DEG_SPOP_SBC_1	20:24	PKSSS	SPOP	0.8424	More...
Q5JSZ5	Protein PRRC2B	DEG_SPOP_SBC_1	96:100	PKSSS	SPOP	0.8516	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	544:548	PKSSS	SPOP	0.9953	More...
Q9BX69	Caspase recruitment domain-containing protein 6	DEG_SPOP_SBC_1	1012:1016	PKSSS	SPOP	0.9263	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	434:438	PKSSS	SPOP	0.9775	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKSSS

Degron related mutations and impact score

Drug responses associated with GOLGA8A mutations

All proteins holding degron of PKSSS