DegronMD

Uniprot ID: Q9Y2I7

Source protein: 1-phosphatidylinositol 3-phosphate 5-kinase

Source gene: PIKFYVE

Class: DEG_SPOP_SBC_1

Location: 1710:1714

E3 ligase: SPOP

DEGRON score: 0.9961

ASA_SCORE: 84.56

COIL: 0.9388

CONS_SCORE: 0.2657

DSS_SCORE: 0.7667

HELIX: 0.035

FCONS_SCORE: 1.1608

RIG_SCORE: 0.5409

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1719L	TCGA-4Z-AA83	BLCA	TCGA	PKSSS	DEG_SPOP_SBC_1	0.1944
p.P1719L	DO51869	BLCA	ICGC	PKSSS	DEG_SPOP_SBC_1	0.1944
p.S1704N	TCGA-BR-8361	STAD	TCGA	PKSSS	DEG_SPOP_SBC_1	0.1667
p.S1704N	DO48032	STAD	ICGC	PKSSS	DEG_SPOP_SBC_1	0.1667
p.S1714N	SIDM02026	Colorectal Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	0.818

Drug responses associated with PIKFYVE mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00918	OV\|ovary	p.R572Q (No)	GDSC	YM201636	14.9278
SIDM00889	CESC\|cervix	p.E829fs*1 (No)	GDSC	YM201636	1.7478
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A1827T (No)	GDSC	YM201636	1.5959
SIDM01029	ESCA\|oesophagus	p.V2051L (No)	GDSC	YM201636	6.3411
SIDM00213	THCA\|thyroid	p.P1521H (No)	GDSC	YM201636	75.4698
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.R1881S (No)	GDSC	YM201636	10.9164
SIDM00499	PRAD\|prostate	p.I229V (No)	GDSC	YM201636	3.5303
SIDM00967	OV\|ovary	p.P818S (No)	GDSC	YM201636	8.4389
SIDM00754	LUAD\|lung_NSCLC_adenocarcinoma	p.I667M (No)	GDSC	YM201636	69.5696
SIDM00901	UCEC\|endometrium	p.A512V (No)	GDSC	YM201636	6.2194
SIDM00957	COREAD\|large_intestine	p.L2094F (No)	GDSC	YM201636	61.6263
SIDM00953	SCLC\|lung_small_cell_carcinoma	p.R176H (No)	GDSC	YM201636	4.1383
SIDM00859	DLBC\|B_cell_lymphoma	p.P77S (No)	GDSC	YM201636	0.4883
SIDM00877	BRCA\|breast	p.H1364D (No)	GDSC	YM201636	3.335
SIDM00620	LGG\|glioma	p.T1764N (No)	GDSC	YM201636	4.7794
SIDM00250	ESCA\|oesophagus	p.T1564A (No)	GDSC	YM201636	40.7615
SIDM00527	COREAD\|large_intestine	p.V337F (No)	GDSC	YM201636	10.9964
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A901G (No)	GDSC	YM201636	4.6072
SIDM01007	ALL\|lymphoblastic_leukemia	p.Y46H (No)	GDSC	YM201636	2.4259
SIDM01007	ALL\|lymphoblastic_leukemia	p.A878S (No)	GDSC	YM201636	2.4259
SIDM01007	ALL\|lymphoblastic_leukemia	p.F1606L (No)	GDSC	YM201636	2.4259
SIDM00664	PAAD\|pancreas	p.V652I (No)	GDSC	YM201636	126.841
SIDM00742	LUAD\|lung_NSCLC_adenocarcinoma	p.V902F (No)	GDSC	YM201636	68.7086
SIDM00466	OV\|ovary	p.M1473L (No)	GDSC	YM201636	2.1923
SIDM00261	UNCLASSIFIED\|ewings_sarcoma	p.Q293P (No)	GDSC	YM201636	0.9244
SIDM00214	COREAD\|large_intestine	p.A691V (No)	GDSC	YM201636	2.354
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.P1593R (No)	GDSC	YM201636	1.9314
SIDM01045	UCEC\|endometrium	p.K162N (No)	GDSC	YM201636	5.7846
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.P450S (No)	GDSC	YM201636	56.3953
SIDM00256	NB\|neuroblastoma	p.K1446E (No)	GDSC	YM201636	3.3857
SIDM00217	COREAD\|large_intestine	p.A106V (No)	GDSC	YM201636	5.0645
SIDM00681	COREAD\|large_intestine	p.E1793V (No)	GDSC	YM201636	4.7949
SIDM00839	COREAD\|large_intestine	p.L2094F (No)	GDSC	YM201636	28.3603
SIDM00216	COREAD\|large_intestine	p.A513T (No)	GDSC	YM201636	1.5906
SIDM00216	COREAD\|large_intestine	p.R1560H (No)	GDSC	YM201636	1.5906
SIDM00282	COREAD\|large_intestine	p.Y1026H (No)	GDSC	YM201636	21.7007
SIDM00282	COREAD\|large_intestine	p.S1034Y (No)	GDSC	YM201636	21.7007
SIDM00637	DLBC\|B_cell_lymphoma	p.S1474F (No)	GDSC	YM201636	2.0845
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.E894V (No)	GDSC	YM201636	3.7282
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.I1427V (No)	GDSC	YM201636	2.0036
SIDM00257	NB\|neuroblastoma	p.A965G (No)	GDSC	YM201636	2.6281
SIDM00382	GBM\|glioma	p.D1604fs*15 (No)	GDSC	YM201636	13.1669
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.M859V (No)	GDSC	YM201636	10.5899
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.E920* (No)	GDSC	YM201636	10.5899
SIDM00789	COREAD\|large_intestine	p.R375C (No)	GDSC	YM201636	10.4792
SIDM00789	COREAD\|large_intestine	p.I1898F (No)	GDSC	YM201636	10.4792
SIDM00273	LGG\|glioma	p.G460R (No)	GDSC	YM201636	6.0988
SIDM00487	COREAD\|large_intestine	p.D12G (No)	GDSC	YM201636	4.5961
SIDM01169	OV\|ovary	p.R1401H (No)	GDSC	YM201636	26.7747
SIDM00255	NB\|neuroblastoma	p.V1279L (No)	GDSC	YM201636	5.2676
SIDM00114	MESO\|mesothelioma	p.S628L (No)	GDSC	YM201636	3.5121
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.A1674T (No)	GDSC	YM201636	5.4175
SIDM00759	LUAD\|lung_NSCLC_adenocarcinoma	p.S514C (No)	GDSC	YM201636	7.092
SIDM00127	HNSC\|head_and_neck	p.R1546L (No)	GDSC	YM201636	10.6644
SIDM01138	PAAD\|pancreas	p.S639L (No)	GDSC	YM201636	13.7477
SIDM00285	NB\|neuroblastoma	p.T1571N (No)	GDSC	YM201636	5.2611
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.E1654D (No)	GDSC	YM201636	24.1933
SIDM00581	GBM\|glioma	p.P584L (No)	GDSC	YM201636	7.3773
SIDM01259	ALL\|lymphoblastic_leukemia	p.R1284H (No)	GDSC	YM201636	1.5408
SIDM00537	COREAD\|large_intestine	p.R54C (No)	GDSC	YM201636	3.208
SIDM00537	COREAD\|large_intestine	p.V290A (No)	GDSC	YM201636	3.208
SIDM00537	COREAD\|large_intestine	p.A1378V (No)	GDSC	YM201636	3.208
SIDM01246	NB\|neuroblastoma	p.H536P (No)	GDSC	YM201636	4.5459
SIDM00384	DLBC\|B_cell_lymphoma	p.L419M (No)	GDSC	YM201636	5.5032
SIDM00837	COREAD\|large_intestine	p.R379I (No)	GDSC	YM201636	21.8994
SIDM00238	OV\|ovary	p.S88P (No)	GDSC	YM201636	9.4778
SIDM00238	OV\|ovary	p.M605T (No)	GDSC	YM201636	9.4778
SIDM00238	OV\|ovary	p.Y1650H (No)	GDSC	YM201636	9.4778
SIDM00113	KIRC\|kidney	p.Q331H (No)	GDSC	YM201636	24.1926
SIDM00817	KIRC\|kidney	p.T1205A (No)	GDSC	YM201636	38.0465
SIDM00852	LGG\|glioma	p.Q987H (No)	GDSC	YM201636	24.2634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15085	Rho guanine nucleotide exchange factor 11	DEG_SPOP_SBC_1	543:547	PKSSS	SPOP	0.7465	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1015:1019	PKSSS	SPOP	0.8719	More...
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	564:568	PKSSS	SPOP	0.9922	More...
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	289:293	PKSSS	SPOP	0.9956	More...
Q15811	Intersectin-1	DEG_SPOP_SBC_1	180:184	PKSSS	SPOP	0.9976	More...
Q5T200	Zinc finger CCCH domain-containing protein 13	DEG_SPOP_SBC_1	225:229	PKSSS	SPOP	0.9834	More...
Q5TCZ1	SH3 and PX domain-containing protein 2A	DEG_SPOP_SBC_1	663:667	PKSSS	SPOP	0.8452	More...
Q6DN12	Multiple C2 and transmembrane domain-containing protein 2	DEG_SPOP_SBC_1	89:93	PKSSS	SPOP	0.7468	More...
Q7L590	Protein MCM10 homolog	DEG_SPOP_SBC_1	200:204	PKSSS	SPOP	0.9805	More...
Q8N3F8	MICAL-like protein 1	DEG_SPOP_SBC_1	534:538	PKSSS	SPOP	0.9952	More...
Q8WYP5	Protein ELYS	DEG_SPOP_SBC_1	1340:1344	PKSSS	SPOP	0.9617	More...
Q96QS3	Homeobox protein ARX	DEG_SPOP_SBC_1	68:72	PKSSS	SPOP	0.583	More...
Q9NXV6	CDKN2A-interacting protein	DEG_SPOP_SBC_1	347:351	PKSSS	SPOP	0.9905	More...
Q9Y2I7	1-phosphatidylinositol 3-phosphate 5-kinase	DEG_SPOP_SBC_1	1710:1714	PKSSS	SPOP	0.9961	More...
Q9Y5X1	Sorting nexin-9	DEG_SPOP_SBC_1	172:176	PKSSS	SPOP	0.9854	More...
A6NHQ2	rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1	DEG_SPOP_SBC_1	329:333	PKSSS	SPOP	0.72	More...
A7E2F4	Golgin subfamily A member 8A	DEG_SPOP_SBC_1	83:87	PKSSS	SPOP	0.7895	More...
Q5H9T9	Fibrous sheath CABYR-binding protein	DEG_SPOP_SBC_1	20:24	PKSSS	SPOP	0.8424	More...
Q5JSZ5	Protein PRRC2B	DEG_SPOP_SBC_1	96:100	PKSSS	SPOP	0.8516	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	544:548	PKSSS	SPOP	0.9953	More...
Q9BX69	Caspase recruitment domain-containing protein 6	DEG_SPOP_SBC_1	1012:1016	PKSSS	SPOP	0.9263	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	434:438	PKSSS	SPOP	0.9775	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKSSS

Degron related mutations and impact score

Drug responses associated with PIKFYVE mutations

All proteins holding degron of PKSSS