DegronMD - Q9NXV6(CDKN2AIP)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S338F	TCGA-77-8136	LUSC	TCGA	LLTPKSS	DEG_SCF_FBW7_1	344:350	Mutation rewiring degron network	0.1667
p.S338F	TCGA-77-8136	LUSC	TCGA	PKSSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.0833
p.S338F	DO26593	LUSC	ICGC	LLTPKSS	DEG_SCF_FBW7_1	344:350	Mutation rewiring degron network	0.1667
p.S338F	DO26593	LUSC	ICGC	PKSSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.0833
p.S340L	TCGA-AN-A0AJ	BRCA	TCGA	LLTPKSS	DEG_SCF_FBW7_1	344:350	Mutation rewiring degron network	0.2222
p.S340L	TCGA-AN-A0AJ	BRCA	TCGA	PKSSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.1389
p.S340L	DO6040	BRCA	ICGC	LLTPKSS	DEG_SCF_FBW7_1	344:350	Mutation rewiring degron network	0.2222
p.S340L	DO6040	BRCA	ICGC	PKSSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.1389
p.P347S	TCGA-Z2-A8RT	SKCM	TCGA	LLTPKSS	DEG_SCF_FBW7_1	344:350	Mutation altering degron motif	0.6752
p.P347S	TCGA-Z2-A8RT	SKCM	TCGA	PKSSS	DEG_SPOP_SBC_1	347:351	Mutation altering degron motif	0.6752
p.P347S	DO51301	SKCM	ICGC	LLTPKSS	DEG_SCF_FBW7_1	344:350	Mutation altering degron motif	0.6752
p.P347S	DO51301	SKCM	ICGC	PKSSS	DEG_SPOP_SBC_1	347:351	Mutation altering degron motif	0.6752
p.P347L	TCGA-Z2-A8RT	SKCM	TCGA	LLTPKSS	DEG_SCF_FBW7_1	344:350	Mutation altering degron motif	0.7582
p.P347L	TCGA-Z2-A8RT	SKCM	TCGA	PKSSS	DEG_SPOP_SBC_1	347:351	Mutation altering degron motif	0.7582
p.P347L	DO51301	SKCM	ICGC	LLTPKSS	DEG_SCF_FBW7_1	344:350	Mutation altering degron motif	0.7582
p.P347L	DO51301	SKCM	ICGC	PKSSS	DEG_SPOP_SBC_1	347:351	Mutation altering degron motif	0.7582
p.S343P	DO228732	GACA	ICGC	LLTPKSS	DEG_SCF_FBW7_1	344:350	Mutation blocking phosphorylation signal	0.75
p.S343P	DO228732	GACA	ICGC	PKSSS	DEG_SPOP_SBC_1	347:351	Mutation blocking phosphorylation signal	0.6667
p.G341V	DO229035	LICA	ICGC	LLTPKSS	DEG_SCF_FBW7_1	344:350	Mutation rewiring degron network	0.25
p.G341V	DO229035	LICA	ICGC	PKSSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.1667
p.K335N	SIDM01611	Endometrial Carcinoma	GDSC	LLTPKSS	DEG_SCF_FBW7_1	344:350	Mutation substituting flanking lysine	0.1944
p.K335N	ACH-000996	Endometrial/Uterine Cancer	CCLE	LLTPKSS	DEG_SCF_FBW7_1	344:350	Mutation substituting flanking lysine	0.1944
p.S356L	SIDM01588	Endometrial Carcinoma	GDSC	LLTPKSS	DEG_SCF_FBW7_1	344:350	Mutation blocking phosphorylation signal	0.6111
p.S356L	SIDM01588	Endometrial Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	347:351	Mutation blocking phosphorylation signal	0.6389
p.S356L	ACH-000993	Endometrial/Uterine Cancer	CCLE	LLTPKSS	DEG_SCF_FBW7_1	344:350	Mutation blocking phosphorylation signal	0.6111
p.S356L	ACH-000993	Endometrial/Uterine Cancer	CCLE	PKSSS	DEG_SPOP_SBC_1	347:351	Mutation blocking phosphorylation signal	0.6389
p.S356L	ACH-001197	Lymphoma	CCLE	LLTPKSS	DEG_SCF_FBW7_1	344:350	Mutation blocking phosphorylation signal	0.6111
p.S356L	ACH-001197	Lymphoma	CCLE	PKSSS	DEG_SPOP_SBC_1	347:351	Mutation blocking phosphorylation signal	0.6389

Kaplan plot for CDKN2AIP in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDKN2AIP

UniProt ID: Q9NXV6

Entrez ID: 55602

Protein name: CDKN2A-interacting protein (Collaborator of ARF)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CDKN2AIP in