DegronMD

Uniprot ID: Q9NXV6

Source protein: CDKN2A-interacting protein

Source gene: CDKN2AIP

Class: DEG_SCF_FBW7_1

Location: 344:350

E3 ligase: FBXW7

DEGRON score: 0.9958

ASA_SCORE: 103.9857

COIL: 0.9567

CONS_SCORE: 0.4347

DSS_SCORE: 0.4971

HELIX: 0.0203

FCONS_SCORE: 0.9578

RIG_SCORE: 0.6344

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S338F	TCGA-77-8136	LUSC	TCGA	LLTPKSS	DEG_SCF_FBW7_1	0.1667
p.S338F	DO26593	LUSC	ICGC	LLTPKSS	DEG_SCF_FBW7_1	0.1667
p.S340L	TCGA-AN-A0AJ	BRCA	TCGA	LLTPKSS	DEG_SCF_FBW7_1	0.2222
p.S340L	DO6040	BRCA	ICGC	LLTPKSS	DEG_SCF_FBW7_1	0.2222
p.P347S	TCGA-Z2-A8RT	SKCM	TCGA	LLTPKSS	DEG_SCF_FBW7_1	0.6752
p.P347S	DO51301	SKCM	ICGC	LLTPKSS	DEG_SCF_FBW7_1	0.6752
p.P347L	TCGA-Z2-A8RT	SKCM	TCGA	LLTPKSS	DEG_SCF_FBW7_1	0.7582
p.P347L	DO51301	SKCM	ICGC	LLTPKSS	DEG_SCF_FBW7_1	0.7582
p.S343P	DO228732	GACA	ICGC	LLTPKSS	DEG_SCF_FBW7_1	0.75
p.G341V	DO229035	LICA	ICGC	LLTPKSS	DEG_SCF_FBW7_1	0.25
p.K335N	SIDM01611	Endometrial Carcinoma	GDSC	LLTPKSS	DEG_SCF_FBW7_1	0.1944
p.K335N	ACH-000996	Endometrial/Uterine Cancer	CCLE	LLTPKSS	DEG_SCF_FBW7_1	0.1944
p.S356L	SIDM01588	Endometrial Carcinoma	GDSC	LLTPKSS	DEG_SCF_FBW7_1	0.6111
p.S356L	ACH-000993	Endometrial/Uterine Cancer	CCLE	LLTPKSS	DEG_SCF_FBW7_1	0.6111
p.S356L	ACH-001197	Lymphoma	CCLE	LLTPKSS	DEG_SCF_FBW7_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NXV6	CDKN2A-interacting protein	DEG_SCF_FBW7_1	344:350	LLTPKSS	FBXW7	0.9958	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons