DegronMD

Uniprot ID: Q9NXV6

Source protein: CDKN2A-interacting protein

Source gene: CDKN2AIP

Class: DEG_SPOP_SBC_1

Location: 347:351

E3 ligase: SPOP

DEGRON score: 0.9905

ASA_SCORE: 102.68

COIL: 0.9552

CONS_SCORE: 0.4273

DSS_SCORE: 0.476

HELIX: 0.0226

FCONS_SCORE: 0.9562

RIG_SCORE: 0.6074

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P347L	TCGA-Z2-A8RT	SKCM	TCGA	PKSSS	DEG_SPOP_SBC_1	0.7582
p.P347L	DO51301	SKCM	ICGC	PKSSS	DEG_SPOP_SBC_1	0.7582
p.P347S	TCGA-Z2-A8RT	SKCM	TCGA	PKSSS	DEG_SPOP_SBC_1	0.6752
p.P347S	DO51301	SKCM	ICGC	PKSSS	DEG_SPOP_SBC_1	0.6752
p.S343P	DO228732	GACA	ICGC	PKSSS	DEG_SPOP_SBC_1	0.6667
p.S356L	SIDM01588	Endometrial Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	0.6389
p.S356L	ACH-000993	Endometrial/Uterine Cancer	CCLE	PKSSS	DEG_SPOP_SBC_1	0.6389
p.S356L	ACH-001197	Lymphoma	CCLE	PKSSS	DEG_SPOP_SBC_1	0.6389
p.G341V	DO229035	LICA	ICGC	PKSSS	DEG_SPOP_SBC_1	0.1667
p.S340L	TCGA-AN-A0AJ	BRCA	TCGA	PKSSS	DEG_SPOP_SBC_1	0.1389
p.S340L	DO6040	BRCA	ICGC	PKSSS	DEG_SPOP_SBC_1	0.1389
p.S338F	TCGA-77-8136	LUSC	TCGA	PKSSS	DEG_SPOP_SBC_1	0.0833
p.S338F	DO26593	LUSC	ICGC	PKSSS	DEG_SPOP_SBC_1	0.0833

Showing 1 to 13 of 13 entries

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Drug responses associated with CDKN2AIP mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PKSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2I7	1-phosphatidylinositol 3-phosphate 5-kinase	DEG_SPOP_SBC_1	1710:1714	PKSSS	SPOP	0.9961	More...
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	564:568	PKSSS	SPOP	0.9922	More...
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	289:293	PKSSS	SPOP	0.9956	More...
Q9BX69	Caspase recruitment domain-containing protein 6	DEG_SPOP_SBC_1	1012:1016	PKSSS	SPOP	0.9263	More...
Q9NXV6	CDKN2A-interacting protein	DEG_SPOP_SBC_1	347:351	PKSSS	SPOP	0.9905	More...
Q5H9T9	Fibrous sheath CABYR-binding protein	DEG_SPOP_SBC_1	20:24	PKSSS	SPOP	0.8424	More...
A7E2F4	Golgin subfamily A member 8A	DEG_SPOP_SBC_1	83:87	PKSSS	SPOP	0.7895	More...
Q96QS3	Homeobox protein ARX	DEG_SPOP_SBC_1	68:72	PKSSS	SPOP	0.583	More...
Q15811	Intersectin-1	DEG_SPOP_SBC_1	180:184	PKSSS	SPOP	0.9976	More...
Q8N3F8	MICAL-like protein 1	DEG_SPOP_SBC_1	534:538	PKSSS	SPOP	0.9952	More...
Q6DN12	Multiple C2 and transmembrane domain-containing protein 2	DEG_SPOP_SBC_1	89:93	PKSSS	SPOP	0.7468	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1015:1019	PKSSS	SPOP	0.8719	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	544:548	PKSSS	SPOP	0.9953	More...
Q8WYP5	Protein ELYS	DEG_SPOP_SBC_1	1340:1344	PKSSS	SPOP	0.9617	More...
Q7L590	Protein MCM10 homolog	DEG_SPOP_SBC_1	200:204	PKSSS	SPOP	0.9805	More...
Q5JSZ5	Protein PRRC2B	DEG_SPOP_SBC_1	96:100	PKSSS	SPOP	0.8516	More...
O15085	Rho guanine nucleotide exchange factor 11	DEG_SPOP_SBC_1	543:547	PKSSS	SPOP	0.7465	More...
A6NHQ2	rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1	DEG_SPOP_SBC_1	329:333	PKSSS	SPOP	0.72	More...
Q5TCZ1	SH3 and PX domain-containing protein 2A	DEG_SPOP_SBC_1	663:667	PKSSS	SPOP	0.8452	More...
Q9Y5X1	Sorting nexin-9	DEG_SPOP_SBC_1	172:176	PKSSS	SPOP	0.9854	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	434:438	PKSSS	SPOP	0.9775	More...
Q5T200	Zinc finger CCCH domain-containing protein 13	DEG_SPOP_SBC_1	225:229	PKSSS	SPOP	0.9834	More...

Showing 1 to 22 of 22 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKSSS

Degron related mutations and impact score

Drug responses associated with CDKN2AIP mutations

All proteins holding degron of PKSSS