DegronMD - Q9Y5X1(SNX9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D168N	TCGA-AG-A01N	READ	TCGA	PKSSS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.2222
p.R281Q	TCGA-B5-A11E	UCEC	TCGA	LTPTNT	DEG_SCF_FBW7_1	274:279	Mutation rewiring degron network	0.2778
p.R281Q	DO41644	UCEC	ICGC	LTPTNT	DEG_SCF_FBW7_1	274:279	Mutation rewiring degron network	0.2778
p.R281Q	SIDM00193	Colorectal Carcinoma	GDSC	LTPTNT	DEG_SCF_FBW7_1	274:279	Mutation rewiring degron network	0.2778
p.R281Q	ACH-000991	Colon/Colorectal Cancer	CCLE	LTPTNT	DEG_SCF_FBW7_1	274:279	Mutation rewiring degron network	0.2778
p.R281Q	SNU-81	large intestine	COSMIC	LTPTNT	DEG_SCF_FBW7_1	274:279	Mutation rewiring degron network	0.2778
p.G187C	TCGA-BS-A0UV	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.0833
p.G187C	DO42793	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.0833
p.N280S	TCGA-CQ-6221	HNSC	TCGA	LTPTNT	DEG_SCF_FBW7_1	274:279	Mutation rewiring degron network	0.3056
p.N280S	DO14622	HNSC	ICGC	LTPTNT	DEG_SCF_FBW7_1	274:279	Mutation rewiring degron network	0.3056
p.L266I	TCGA-D3-A2JP	SKCM	TCGA	LTPTNT	DEG_SCF_FBW7_1	274:279	Mutation rewiring degron network	0.1111
p.L266I	DO47407	SKCM	ICGC	LTPTNT	DEG_SCF_FBW7_1	274:279	Mutation rewiring degron network	0.1111
p.R286M	TCGA-DU-6392	LGG	TCGA	LTPTNT	DEG_SCF_FBW7_1	274:279	Mutation rewiring degron network	0.1389
p.R286M	DO22237	LGG	ICGC	LTPTNT	DEG_SCF_FBW7_1	274:279	Mutation rewiring degron network	0.1389
p.G188S	TCGA-EO-A22R	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1111
p.G188S	DO42713	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1111
p.T382A	TCGA-EY-A1GI	UCEC	TCGA	ERDELAGVM	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.2222
p.T382A	DO41211	UCEC	ICGC	ERDELAGVM	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.2222
p.R281L	TCGA-KQ-A41N	BLCA	TCGA	LTPTNT	DEG_SCF_FBW7_1	274:279	Mutation rewiring degron network	0.2778
p.R281L	DO223588	BLCA	ICGC	LTPTNT	DEG_SCF_FBW7_1	274:279	Mutation rewiring degron network	0.2778
p.P209S	TCGA-W3-A824	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.0833
p.P209S	DO51271	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.0833
p.S199L	DO225221	BRCA	ICGC	ASSSS	DEG_SPOP_SBC_1	196:200	Mutation altering degron motif	0.8778
p.H285R	DO222849	COCA	ICGC	LTPTNT	DEG_SCF_FBW7_1	274:279	Mutation rewiring degron network	0.1667
p.G192V	DO229034	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.2222
p.S268I	DO229006	LICA	ICGC	LTPTNT	DEG_SCF_FBW7_1	274:279	Mutation rewiring degron network	0.1667
p.R286W	DO231078	LUSC	ICGC	LTPTNT	DEG_SCF_FBW7_1	274:279	Mutation rewiring degron network	0.1389
p.E271K	DO228338	MALY	ICGC	LTPTNT	DEG_SCF_FBW7_1	274:279	Mutation rewiring degron network	0.25
p.E271K	SIDM00217	Colorectal Carcinoma	GDSC	LTPTNT	DEG_SCF_FBW7_1	274:279	Mutation rewiring degron network	0.25
p.E271K	ACH-000999	Colon/Colorectal Cancer	CCLE	LTPTNT	DEG_SCF_FBW7_1	274:279	Mutation rewiring degron network	0.25
p.E271K	SNU-1040	large intestine	COSMIC	LTPTNT	DEG_SCF_FBW7_1	274:279	Mutation rewiring degron network	0.25
p.F380L	DO27903	ORCA	ICGC	ERDELAGVM	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.2778
p.S199P	DO229272	THCA	ICGC	ASSSS	DEG_SPOP_SBC_1	196:200	Mutation altering degron motif	0.7863
p.N193K	SIDM01119	Other Solid Cancers	GDSC	ASSSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.25
p.N193K	ACH-000775	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.25
p.N193K	NCI-H727	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.25
p.D185A	SIDM00195	Ewing's Sarcoma	GDSC	PKSSS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.0833
p.D185A	ACH-002117	Bone Cancer	CCLE	PKSSS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.0833
p.D185A	EW-24	bone	COSMIC	PKSSS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.0833
p.K363N	SIDM01611	Endometrial Carcinoma	GDSC	ERDELAGVM	DEG_APCC_DBOX_1	370:378	Mutation substituting flanking lysine	0.25

Kaplan plot for SNX9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SNX9

UniProt ID: Q9Y5X1

Entrez ID: 51429

Protein name: Sorting nexin-9 (SH3 and PX domain-containing protein 1) (Protein SDP1) (SH3 and PX domain-containing protein 3A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SNX9 in