DegronMD

Uniprot ID: Q9Y5X1

Source protein: Sorting nexin-9

Source gene: SNX9

Class: DEG_APCC_DBOX_1

Location: 370:378

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7392

ASA_SCORE: 81.2333

COIL: 0.5771

CONS_SCORE: 0.5167

DSS_SCORE: 0.3618

HELIX: 0.2962

FCONS_SCORE: 1.0491

RIG_SCORE: 0.7904

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T382A	TCGA-EY-A1GI	UCEC	TCGA	ERDELAGVM	DEG_APCC_DBOX_1	0.2222
p.T382A	DO41211	UCEC	ICGC	ERDELAGVM	DEG_APCC_DBOX_1	0.2222
p.F380L	DO27903	ORCA	ICGC	ERDELAGVM	DEG_APCC_DBOX_1	0.2778
p.K363N	SIDM01611	Endometrial Carcinoma	GDSC	ERDELAGVM	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5X1	Sorting nexin-9	DEG_APCC_DBOX_1	370:378	ERDELAGVM	APC,CDC20,FZR1	0.7392	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons